Search Results - "Hatırnaz, Özden"

Tackling TKI resistance in AML: A commentary on “Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML.” by Yamatani et al by Hatırnaz Ng, Özden, Eşkazan, Ahmet Emre

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PTEN and AKT1 Variations in Childhood T-Cell Acute Lymphoblastic Leukemia by Küçükcankurt, Fulya, Erbilgin, Yücel, Fırtına, Sinem, Hatırnaz Ng, Özden, Karakaş, Zeynep, Celkan, Tiraje, Ünüvar, Ayşegül, Özbek, Uğur, Sayitoğlu, Müge

“…PTEN/AKT pathway deregulations have been reported to be associated with treatment response in acute leukemia. This study examined pediatric T-cell acute…”
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Determining T and B Cell development by TREC/KREC analysis in primary immunodeficiency patients and healthy controls by Şentürk, Gizem, Ng, Yuk Yin, Eltan, Sevgi Bilgiç, Başer, Dilek, Ogulur, Ismail, Altındirek, Didem, Fırtına, Sinem, Yılmaz, Hülya, Kocamış, Burcu, Kıykım, Ayça, Camcıoğlu, Yıldız, Ar, Muhlis Cem, Sudutan, Tuğçe, Beken, Serdar, Temel, Şehime G., Alanay, Yasemin, Karakoc‐Aydiner, Elif, Barış, Safa, Özen, Ahmet, Özbek, Uğur, Sayitoğlu, Müge, Hatırnaz Ng, Özden

“…T cell receptor excision circles (TRECs) and kappa‐deleting excision circles (KRECs) are DNA fragments potentially indicative of T and B cell development,…”
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A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia by Hatırnaz Ng, Özden, Fırtına, Sinem, Can, İsmail, Karakaş, Zeynep, Ağaoğlu, Leyla, Doğru, Ömer, Celkan, Tiraje, Akçay, Arzu, Yıldırmak, Yıldız, Timur, Çetin, Özbek, Uğur, Sayitoğlu, Müge

“…WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether…”
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Memantine and SKF82958 but not an enriched environment modulate naloxone-precipitated morphine abstinence syndrome without affecting hippocampal tPA mRNA levels in rats by Aslan, Abdurrahman, Hatırnaz-Ng, Özden, Taşar, Orçun, Özbek, Uğur, Yamantürk-Çelik, Pınar

“…There is accumulating evidence supporting the involvement of tissue-plasminogen activator (tPA) in the mechanisms underlying the effects of morphine and an…”
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The potential protective roles of zinc, selenium and glutathione on hypoxia-induced TRPM2 channel activation in transfected HEK293 cells by Duzgun Ergun, Dilek, Dursun, Sefik, Pastaci Ozsobaci, Nural, Hatırnaz Ng, Ozden, Naziroglu, Mustafa, Ozcelik, Dervis

“…Hypoxia induces cell death through excessive production of reactive oxygen species (ROS) and calcium (Ca 2+ ) influx in cells and TRPM2 cation channel is…”
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Long‐term immunological changes after corrective cardiac surgery by Bilgic‐Eltan, Sevgi, Amirov, Razin, Babayeva, Royale, Yorgun Altunbas, Melek, Karakurt, Tuba, Can, Salim, Yalcin Gungoren, Ezgi, Bozkurt, Selcen, Ozturk, Necmiye, Catak, Mehmet Cihangir, Bulutoglu, Alper, Onder, Gizem, Ng, Yuk Yin, Hatırnaz Ng, Ozden, Karakoc‐Aydiner, Elif, Ozen, Ahmet Oguzhan, Baris, Safa

“…Infants with congenital heart disease (CHD) often undergo thymectomy during corrective cardiac surgery (CCS). The long‐term immunological effects remain…”
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Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL) by Sayitoğlu, Müge, Erbilgin, Yücel, Hatırnaz Ng, Ozden, Yıldız, Inci, Celkan, Tiraje, Anak, Sema, Devecioğlu, Omer, Aydoğan, Gönül, Karaman, Serap, Sarper, Nazan, Timur, Cetin, Ure, Umit, Ozbek, Uğur

“…T-cell acute lymphoblastic leukemia (T-ALL) is associated with recurrent chromosomal aberrations andabnormal ectopic gene expression during T-cell development…”
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Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure by Hatirnaz Ng, Ozden, Akyoney, Sezer, Sahin, Ilayda, Soykam, Huseyin Okan, Bayram Akcapinar, Gunseli, Ozdemir, Ozkan, Kancagi, Derya Dilek, Sir Karakus, Gozde, Yurtsever, Bulut, Kocagoz, Ayse Sesin, Ovali, Ercument, Ozbek, Ugur

“…The Coronavirus Disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). As of May 25th, 2021 there were 2.059.941…”
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Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates by Sir Karakus, Gozde, Tastan, Cihan, Dilek Kancagi, Derya, Yurtsever, Bulut, Tumentemur, Gamze, Demir, Sevda, Turan, Raife Dilek, Abanuz, Selen, Cakirsoy, Didem, Seyis, Utku, Ozer, Samed, Elibol, Omer, Elek, Muhammer, Ertop, Gurcan, Arbak, Serap, Acikel Elmas, Merve, Hemsinlioglu, Cansu, Kocagoz, Ayse Sesin, Hatirnaz Ng, Ozden, Akyoney, Sezer, Sahin, Ilayda, Ozbek, Ugur, Telci, Dilek, Sahin, Fikrettin, Yalcin, Koray, Ratip, Siret, Ovali, Ercument

“…COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines…”
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Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice by Turan, Raife Dilek, Tastan, Cihan, Dilek Kancagi, Derya, Yurtsever, Bulut, Sir Karakus, Gozde, Ozer, Samed, Abanuz, Selen, Cakirsoy, Didem, Tumentemur, Gamze, Demir, Sevda, Seyis, Utku, Kuzay, Recai, Elek, Muhammer, Kocaoglu, Miyase Ezgi, Ertop, Gurcan, Arbak, Serap, Acikel Elmas, Merve, Hemsinlioglu, Cansu, Hatirnaz Ng, Ozden, Akyoney, Sezer, Sahin, Ilayda, Kayhan, Cavit Kerem, Tokat, Fatma, Akpinar, Gurler, Kasap, Murat, Kocagoz, Ayse Sesin, Ozbek, Ugur, Telci, Dilek, Sahin, Fikrettin, Yalcin, Koray, Ratip, Siret, Ince, Umit, Ovali, Ercument

“…The SARS-CoV-2 virus caused the most severe pandemic around the world, and vaccine development for urgent use became a crucial issue. Inactivated virus…”
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Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart by USTUNOVA, SAVAS, TAKIR, SELCUK, YILMAZER, NADIM, BULUT, HURI, ALTINDIREK, DIDEM, NG, OZDEN HATIRNAZ, TANSEL, CIHAN DEMIRCI, DOGAN, B. SONMEZ UYDES, OZBEK, UGUR, ARMUTAK, ELIF ILKAY, GUREVIN, EBRU GUREL

“…BACKGROUND/AIMThis study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in…”
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Obstacles and expectations of rare disease patients and their families in Türkiye: ISTisNA project survey results by Hatirnaz Ng, Ozden, Sahin, Ilayda, Erbilgin, Yucel, Ozdemir, Ozkan, Yucesan, Emrah, Erturk, Nazli, Yemenici, Merve, Akgun Dogan, Ozlem, Ugur Iseri, Sibel Aylin, Satman, Ilhan, Alanay, Yasemin, Ozbek, Ugur

“…Rare disease patients constitute a significant part of the healthcare system of all countries. However, the information on the experiences during disease…”
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Genomic disparity impacts variant classification of cancer susceptibility genes in Turkish breast cancer patients by Agaoglu, Nihat B., Unal, Busra, Hayes, Connor P., Walker, McKenzie, Ng, Ozden Hatirnaz, Doganay, Levent, Can, Nisan D., Rana, Huma Q., Ghazani, Arezou A.

“…Objective Turkish genome is underrepresented in large genomic databases. This study aims to evaluate the effect of allele frequency in the Turkish population…”
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A new line method; A direct test in spinal muscular atrophy screening for DBS by Kubar, Ayhan, Temel, Sehime Gülsüm, Beken, Serdar, Onder, Gizem, Hatirnaz, Ozden, Korkmaz, Ayse, Alanay, Yasemin, Ozbek, Ugur, Sag, Sebnem Ozemri, Ergoren, Mahmut Cerkez, Kubar, Elif, Sonmezalp, Candan Zeynep, Doğan, Ozlem

“…Background Nucleic acid‐based assays provide an opportunity to screen for genetically encoded diseases like spinal muscular atrophy (SMA), before the onset of…”
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Impact of TP53 gene variants on prognosis and survival of childhood acute lymphoblastic leukemia by Firtina, Sinem, Erbilgin, Yucel, Hatirnaz Ng, Ozden, Karaman, Serap, Karakas, Zeynep, Celkan, Tulin Tiraje, Gelen, Sema Aylan, Yildirmak, Yildiz, Ozbek, Ugur, Sayitoglu, Muge

“…The tumor suppressor protein 53 (TP53) gene is one of the most studied genes in cancer. Although TP53 variants are rare events in acute leukemia, recent…”
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Hücre Serilerinde Kilitli Nükleik Asitler İle MIR223 Gen Sessizleştirmesi by Taşar, Orçun, Sayitoğlu, Müge, Hatırnaz Ng, Özden

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ABL gene kinase domain mutation scanning by denaturing high performance liquid chromatography sequencing method by Yücel Erbilgin, Suzin Çatal, Ahmet Emre Eşkazan, Özden Hatırnaz, Teoman Soysal, Uğur Özbek

“…Objective: Despite the efficacy of the BCR-ABL tyrosine kinase inhibitor imatinib, the development of resistance against imatinib has been observed. The most…”
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Minimal Residual Disease (MRD) Detection with Translocations and T-Cell Receptor and Immunoglobulin Gene Rearrangements in Adult Acute Lymphoblastic Leukaemia Patients: A Pilot Study by Sayitoğlu, Müge, Ar, M Cem, Hatırnaz, Özden, Öngören, Şeniz, Üre, Ümit, Başlar, Zafer, Sırma, Sema, Aydın, Yıldız, Özbek, Uğur, Ferhanoğlu, Burhan

“…Monitoring minimal residual disease has become increasingly important in clinical practice of ALL management. Break-point fusion regions of leukaemia related…”
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Deep sequencing of BCR-ABL1 kinase domain mutations in chronic myeloid leukemia patients with resistance to tyrosine kinase inhibitors by Erbilgin, Yucel, Eskazan, Ahmet Emre, Hatirnaz Ng, Ozden, Salihoglu, Ayse, Elverdi, Tugrul, Firtina, Sinem, Tasar, Orcun, Mercan, Sevcan, Sisko, Sinem, Khodzhaev, Khusan, Ongoren, Seniz, Ar, Muhlis Cem, Baslar, Zafer, Soysal, Teoman, Sayitoglu, Muge, Ozbek, Ugur

“…Tyrosine kinase inhibitor (TKI) therapy is the current treatment of choice for patients with chronic phase chronic myeloid leukemia (CML) leading to rapid and…”
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