Search Results - "Hasumi, Kenichiro"
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Combined phospholipids adjuvant augments anti-tumor immune responses through activated tumor-associated dendritic cells
Published in Neoplasia (New York, N.Y.) (01-05-2023)“…•cPLs augments the anti-tumor immune responses.•cPLs changes the phenotype of TADCs from suppressive to promotive.•cPLs enhances the production of cytokine in…”
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Long-lasting complete remission in a patient with systemic metastases of recurrent breast cancer treated with cyclin-dependent kinases 4/6 inhibitors: a case report
Published in Journal of medical case reports (09-05-2023)“…The prognosis for recurrence cases of hormone receptor-positive HER2-negative breast cancer remains poor, and treatment strategies that emphasize quality of…”
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A One-Armed Phase I Dose Escalation Trial Design: Personalized Vaccination with IKKβ-Matured, RNA-Loaded Dendritic Cells for Metastatic Uveal Melanoma
Published in Frontiers in immunology (04-02-2022)“…Uveal melanoma (UM) is an orphan disease with a mortality of 80% within one year upon the development of metastatic disease. UM does hardly respond to…”
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Clinical response of advanced cancer patients to cellular immunotherapy and intensity-modulated radiation therapy
Published in Oncoimmunology (01-10-2013)“…Patients afflicted with advanced cancers were treated with the intratumoral injection of autologous immature dendritic cells (iDCs) followed by activated…”
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Ex-vivo expanded human NK cells express activating receptors that mediate cytotoxicity of allogeneic and autologous cancer cell lines by direct recognition and antibody directed cellular cytotoxicity
Published in Journal of experimental & clinical cancer research (11-10-2010)“…The possibility that autologous NK cells could serve as an effective treatment modality for solid tumors has long been considered. However, implementation is…”
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Selective boron delivery by intra-arterial injection of BSH-WOW emulsion in hepatic cancer model for neutron capture therapy
Published in British journal of radiology (01-06-2017)“…Boron neutron-capture therapy (BNCT) has been used to inhibit the growth of various types of cancers. In this study, we developed a BSH-entrapped…”
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Total HLA class I loss in a sarcomatoid renal carcinoma cell line caused by the coexistence of distinct mutations in the two encoding β₂-microglobulin genes
Published in Cancer Immunology, Immunotherapy (01-03-2009)“…In renal cell carcinoma (RCC), HLA class I downregulation has been found in about 40% of the lesions examined. Since only scanty information is available about…”
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Case report: two cases of extremely rare primary pure squamous cell carcinoma of the breast
Published in Medicine (Baltimore) (01-09-2018)“…Since primary pure squamous cell carcinoma of the breast is a rare disease, few reports describe the characteristic findings on performing preoperative imaging…”
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β-glucan from Aureobasidium pullulans augments the anti-tumor immune responses through activated tumor-associated dendritic cells
Published in International immunopharmacology (01-12-2021)“…•AP-BG augments the anti-tumor immune responses.•AP-BG changes the phenotype of TADCs from suppressive to promotive.•AP-BG enhances the production of cytolytic…”
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Hypoxic Conditions Promote Gemcitabine Sensitivity in a Pancreatic Cancer Stem Cell Line
Published in Anticancer research (01-02-2016)“…Development of an effective therapeutic strategy for refractory pancreatic cancer must consider whether chemosensitivity can be induced in chemoresistant…”
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Sugar-carrying Polystyrenes Facilitate Harvesting of APCs from MLRs: Possible Application of Sugar-carrying Polystyrenes to Immunotherapy
Published in Anticancer research (01-02-2016)“…Antigen-presenting cells (APCs) play a pivotal role in cancer immunotherapy. APCs in conventionally used flasks are harvested by enzymatic digestion or cell…”
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Combining Conventional Therapies with Intratumoral Injection of Autologous Dendritic Cells and Activated T Cells to Treat Patients with Advanced Cancers
Published in Annals of the New York Academy of Sciences (01-09-2009)“…Dendritic cells (DCs) are potent antigen‐presenting cells that have been used in cancer immunotherapy. To take advantage of the ability of DCs to acquire…”
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Therapeutic response in patients with advanced malignancies treated with combined dendritic cell-activated T cell based immunotherapy and intensity-modulated radiotherapy
Published in Cancers (28-04-2011)“…Successful cancer immunotherapy is confounded by the magnitude of the tumor burden and the presence of immunoregulatory elements that suppress an immune…”
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Total HLA class I loss in a sarcomatoid renal carcinoma cell line caused by the coexistence of distinct mutations in the two encoding [beta]2-microglobulin genes
Published in Cancer immunology, immunotherapy (01-03-2009)“…In renal cell carcinoma (RCC), HLA class I downregulation has been found in about 40% of the lesions examined. Since only scanty information is available about…”
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Total HLA class I loss in a sarcomatoid renal carcinoma cell line caused by the coexistence of distinct mutations in the two encoding beta 2-microglobulin genes
Published in Cancer Immunology, Immunotherapy (01-03-2009)“…In renal cell carcinoma (RCC), HLA class I downregulation has been found in about 40% of the lesions examined. Since only scanty information is available about…”
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Products of anti-CD3/anti-CD28 activated lymphocytes induce differentiation and maturation of dendritic cells and have adjuvant-like activity in vitro and in vivo
Published in Clinical immunology (Orlando, Fla.) (01-10-2008)“…Abstract Dendritic cells (DC) orchestrate immune responses under direction of cytokines/chemokines in their microenvironment. To investigate the influence of…”
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Combination of monocyte-derived dendritic cells and activated T cells which express CD40 ligand: a new approach to cancer immunotherapy
Published in Cancer Immunology, Immunotherapy (01-01-2004)“…Interactions between dendritic cells (DCs) and activated T cells are critically important for the establishment of an effective immune response. To develop the…”
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