Search Results - "Hastoy, Benoît"

The β-cell assassin: IAPP cytotoxicity by Raleigh, Daniel, Zhang, Xiaoxue, Hastoy, Benoît, Clark, Anne

“…Islet amyloid polypeptide (IAPP) forms cytotoxic oligomers and amyloid fibrils in islets in type 2 diabetes (T2DM). The causal factors for amyloid formation…”
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A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis by Hastoy, Benoît, Scotti, Pier A., Milochau, Alexandra, Fezoua-Boubegtiten, Zahia, Rodas, Jorge, Megret, Rémi, Desbat, Bernard, Laguerre, Michel, Castano, Sabine, Perrais, David, Rorsman, Patrik, Oda, Reiko, Lang, Jochen

“…Exocytosis depends on cytosolic domains of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains controversial. The…”
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Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells by Hastoy, Benoît, Godazgar, Mahdieh, Clark, Anne, Nylander, Vibe, Spiliotis, Ioannis, van de Bunt, Martijn, Chibalina, Margarita V., Barrett, Amy, Burrows, Carla, Tarasov, Andrei I., Scharfmann, Raphael, Gloyn, Anna L., Rorsman, Patrik

“…Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used…”
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Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion by Vergari, Elisa, Knudsen, Jakob G., Ramracheya, Reshma, Salehi, Albert, Zhang, Quan, Adam, Julie, Asterholm, Ingrid Wernstedt, Benrick, Anna, Briant, Linford J. B., Chibalina, Margarita V., Gribble, Fiona M., Hamilton, Alexander, Hastoy, Benoit, Reimann, Frank, Rorsman, Nils J. G., Spiliotis, Ioannis I., Tarasov, Andrei, Wu, Yanling, Ashcroft, Frances M., Rorsman, Patrik

“…Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers…”
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Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics by Ast, Julia, Arvaniti, Anastasia, Fine, Nicholas H. F., Nasteska, Daniela, Ashford, Fiona B., Stamataki, Zania, Koszegi, Zsombor, Bacon, Andrea, Jones, Ben J., Lucey, Maria A., Sasaki, Shugo, Brierley, Daniel I., Hastoy, Benoit, Tomas, Alejandra, D’Agostino, Giuseppe, Reimann, Frank, Lynn, Francis C., Reissaus, Christopher A., Linnemann, Amelia K., D’Este, Elisa, Calebiro, Davide, Trapp, Stefan, Johnsson, Kai, Podewin, Tom, Broichhagen, Johannes, Hodson, David J.

“…The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to…”
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Loss of ZnT8 function protects against diabetes by enhanced insulin secretion by Dwivedi, Om Prakash, Lehtovirta, Mikko, Hastoy, Benoit, Chandra, Vikash, Krentz, Nicole A. J., Kleiner, Sandra, Jain, Deepak, Richard, Ann-Marie, Abaitua, Fernando, Beer, Nicola L., Grotz, Antje, Prasad, Rashmi B., Hansson, Ola, Ahlqvist, Emma, Krus, Ulrika, Artner, Isabella, Suoranta, Anu, Gomez, Daniel, Baras, Aris, Champon, Benoite, Payne, Anthony J., Moralli, Daniela, Thomsen, Soren K., Kramer, Philipp, Spiliotis, Ioannis, Ramracheya, Reshma, Chabosseau, Pauline, Theodoulou, Andria, Cheung, Rebecca, van de Bunt, Martijn, Flannick, Jason, Trombetta, Maddalena, Bonora, Enzo, Wolheim, Claes B., Sarelin, Leena, Bonadonna, Riccardo C., Rorsman, Patrik, Davies, Benjamin, Brosnan, Julia, McCarthy, Mark I., Otonkoski, Timo, Lagerstedt, Jens O., Rutter, Guy A., Gromada, Jesper, Gloyn, Anna L., Tuomi, Tiinamaija, Groop, Leif

“…A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2…”
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GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation by Shigeto, Makoto, Ramracheya, Reshma, Tarasov, Andrei I, Cha, Chae Young, Chibalina, Margarita V, Hastoy, Benoit, Philippaert, Koenraad, Reinbothe, Thomas, Rorsman, Nils, Salehi, Albert, Sones, William R, Vergari, Elisa, Weston, Cathryn, Gorelik, Julia, Katsura, Masashi, Nikolaev, Viacheslav O, Vennekens, Rudi, Zaccolo, Manuela, Galione, Antony, Johnson, Paul R V, Kaku, Kohei, Ladds, Graham, Rorsman, Patrik

“…Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated…”
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AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity by Gorvin, Caroline M., Rogers, Angela, Hastoy, Benoit, Tarasov, Andrei I., Frost, Morten, Sposini, Silvia, Inoue, Asuka, Whyte, Michael P., Rorsman, Patrik, Hanyaloglu, Aylin C., Breitwieser, Gerda E., Thakker, Rajesh V.

“…Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is…”
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Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion by Gheni, Ghupurjan, Ogura, Masahito, Iwasaki, Masahiro, Yokoi, Norihide, Minami, Kohtaro, Nakayama, Yasumune, Harada, Kazuo, Hastoy, Benoit, Wu, Xichen, Takahashi, Harumi, Kimura, Kazushi, Matsubara, Toshiya, Hoshikawa, Ritsuko, Hatano, Naoya, Sugawara, Kenji, Shibasaki, Tadao, Inagaki, Nobuya, Bamba, Takeshi, Mizoguchi, Akira, Fukusaki, Eiichiro, Rorsman, Patrik, Seino, Susumu

“…Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The…”
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RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells by Chandra, Vikash, Albagli-Curiel, Olivier, Hastoy, Benoit, Piccand, Julie, Randriamampita, Clotilde, Vaillant, Emmanuel, Cavé, Hélène, Busiah, Kanetee, Froguel, Philippe, Vaxillaire, Martine, Rorsman, Patrik, Polak, Michel, Scharfmann, Raphael

“…Development and function of pancreatic β cells involve the regulated activity of specific transcription factors. RFX6 is a transcription factor essential for…”
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Platelet‐derived lipids promote insulin secretion of pancreatic β cells by Karwen, Till, Kolczynska‐Matysiak, Katarzyna, Gross, Carina, Löffler, Mona C, Friedrich, Mike, Loza‐Valdes, Angel, Schmitz, Werner, Wit, Magdalena, Dziaczkowski, Filip, Belykh, Andrei, Trujillo‐Viera, Jonathan, El‐Merahbi, Rabih, Deppermann, Carsten, Nawaz, Sameena, Hastoy, Benoit, Demczuk, Agnieszka, Erk, Manuela, Wieckowski, Mariusz R, Rorsman, Patrik, Heinze, Katrin G, Stegner, David, Nieswandt, Bernhard, Sumara, Grzegorz

“…Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises…”
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Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics by Ast, Julia, Arvaniti, Anastasia, Fine, Nicholas H. F., Nasteska, Daniela, Ashford, Fiona B., Stamataki, Zania, Koszegi, Zsombor, Bacon, Andrea, Jones, Ben J., Lucey, Maria A., Sasaki, Shugo, Brierley, Daniel I., Hastoy, Benoit, Tomas, Alejandra, D’Agostino, Giuseppe, Reimann, Frank, Lynn, Francis C., Reissaus, Christopher A., Linnemann, Amelia K., D’Este, Elisa, Calebiro, Davide, Trapp, Stefan, Johnsson, Kai, Podewin, Tom, Broichhagen, Johannes, Hodson, David J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations by Gupta, Shailesh Kumar, Wesolowska-Andersen, Agata, Ringgaard, Anna K., Jaiswal, Himjyot, Song, Luyan, Hastoy, Benoit, Ingvorsen, Camilla, Taheri-Ghahfarokhi, Amir, Magnusson, Björn, Maresca, Marcello, Jensen, Rikke R., Beer, Nicola L., Fels, Johannes J., Grunnet, Lars G., Thomas, Melissa K., Gloyn, Anna L., Hicks, Ryan, McCarthy, Mark I., Hansson, Mattias, Honoré, Christian

“…Recent studies have reported significant advances in the differentiation of human pluripotent stem cells to clinically relevant cell types such as the insulin…”
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A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function by Grotz, Antje K., Abaitua, Fernando, Navarro-Guerrero, Elena, Hastoy, Benoit, Ebner, Daniel, Gloyn, Anna L.

“…Type 2 diabetes (T2D) is a global pandemic with a strong genetic component, but most causal genes influencing the disease risk remain unknown. It is clear,…”
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Type-2 Diabetes - A Fusion Pore Disease? by Rorsman, Patrik, Collins, Stephan C., Hastoy, Benoit

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338.2: Oxygenated hypothermic machine perfusion of the pancreas; a porcine circulatory death model to compare a ‘continuous’ and an ‘end-ischaemic’ approach by Elzawahry, Mohamed A, Fallon, John, Nawaz, Sameena, Hastoy, Benoit, Clark, Anne, Friend, Peter J, Ploeg, Rutger J, Hunter, James

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MicroRNA-7a regulates pancreatic β cell function by Latreille, Mathieu, Hausser, Jean, Stützer, Ina, Zhang, Quan, Hastoy, Benoit, Gargani, Sofia, Kerr-Conte, Julie, Pattou, Francois, Zavolan, Mihaela, Esguerra, Jonathan L S, Eliasson, Lena, Rülicke, Thomas, Rorsman, Patrik, Stoffel, Markus

“…Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease…”
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Fusion pore in exocytosis: More than an exit gate? A β-cell perspective by Hastoy, Benoit, Clark, Anne, Rorsman, Patrik, Lang, Jochen

“…[Display omitted] •Exocytosis requires structural dynamics and mobility of SNARE protein transmembrane domains.•SNARE transmembrane domains closely interact…”
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The transmembrane domain of the SNARE protein VAMP2 is highly sensitive to its lipid environment by Fezoua-Boubegtiten, Zahia, Hastoy, Benoit, Scotti, Pier, Milochau, Alexandra, Bathany, Katell, Desbat, Bernard, Castano, Sabine, Oda, Reiko, Lang, Jochen

“…Neurotransmitter and hormone exocytosis depends on SNARE protein transmembrane domains and membrane lipids but their interplay is poorly understood. We…”
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Electrophysiological Characterization of Inducible Pluripotent Stem Cell-Derived Human β-Like Cells and an SLC30A8 Disease Model by Jaffredo, Manon, Krentz, Nicole A J, Champon, Benoite, Duff, Claire E, Nawaz, Sameena, Beer, Nicola, Honore, Christian, Clark, Anne, Rorsman, Patrik, Lang, Jochen, Gloyn, Anna L, Raoux, Matthieu, Hastoy, Benoit

“…Inducible pluripotent stem cell-derived human β-like cells (BLCs) hold promise for both therapy and disease modeling, but their generation remains challenging…”
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