Search Results - "Hastings, K."

EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer by Hastings, K., Yu, H.A., Wei, W., Sanchez-Vega, F., DeVeaux, M., Choi, J., Rizvi, H., Lisberg, A., Truini, A., Lydon, C.A., Liu, Z., Henick, B.S., Wurtz, A., Cai, G., Plodkowski, A.J., Long, N.M., Halpenny, D.F., Killam, J., Oliva, I., Schultz, N., Riely, G.J., Arcila, M.E., Ladanyi, M., Zelterman, D., Herbst, R.S., Goldberg, S.B., Awad, M.M., Garon, E.B., Gettinger, S., Hellmann, M.D., Politi, K.

“…Although EGFR mutant tumors exhibit low response rates to immune checkpoint blockade overall, some EGFR mutant tumors do respond to these therapies; however,…”
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Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer by Fernandez-Garcia, Daniel, Hills, Allison, Page, Karen, Hastings, Robert K, Toghill, Bradley, Goddard, Kate S, Ion, Charlotte, Ogle, Olivia, Boydell, Anna Rita, Gleason, Kelly, Rutherford, Mark, Lim, Adrian, Guttery, David S, Coombes, R Charles, Shaw, Jacqueline A

“…Breast cancer (BC) is the most common cancer in women, and despite the introduction of new screening programmes, therapies and monitoring technologies, there…”
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Major histocompatibility complex class II in the tumor microenvironment: functions of nonprofessional antigen-presenting cells by Macy, Anne M, Herrmann, Lauren M, Adams, Anngela C, Hastings, K Taraszka

“…Major histocompatibility complex class-II-restricted presentation by nonprofessional antigen-presenting cells in the tumor microenvironment can regulate…”
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GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen by Rausch, Matthew P, Meador, Lydia R, Metzger, Todd C, Li, Handong, Qiu, Shenfeng, Anderson, Mark S, Hastings, K Taraszka

“…Central tolerance prevents autoimmunity, but also limits T cell responses to potentially immunodominant tumor epitopes with limited expression in healthy…”
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Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer by Guttery, David S, Page, Karen, Hills, Allison, Woodley, Laura, Marchese, Stephanie D, Rghebi, Basma, Hastings, Robert K, Luo, Jinli, Pringle, J Howard, Stebbing, Justin, Coombes, R Charles, Ali, Simak, Shaw, Jacqueline A

“…Activating mutations in the estrogen receptor 1 (ESR1) gene are acquired on treatment and can drive resistance to endocrine therapy. Because of the spatial and…”
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TAM Receptors Are Not Required for Zika Virus Infection in Mice by Hastings, Andrew K., Yockey, Laura J., Jagger, Brett W., Hwang, Jesse, Uraki, Ryuta, Gaitsch, Hallie F., Parnell, Lindsay A., Cao, Bin, Mysorekar, Indira U., Rothlin, Carla V., Fikrig, Erol, Diamond, Michael S., Iwasaki, Akiko

“…Tyro3, Axl, and Mertk (TAM) receptors are candidate entry receptors for infection with the Zika virus (ZIKV), an emerging flavivirus of global public health…”
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EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer by Amato, Katherine R, Wang, Shan, Tan, Li, Hastings, Andrew K, Song, Wenqiang, Lovly, Christine M, Meador, Catherine B, Ye, Fei, Lu, Pengcheng, Balko, Justin M, Colvin, Daniel C, Cates, Justin M, Pao, William, Gray, Nathanael S, Chen, Jin

“…Despite the success of treating EGFR-mutant lung cancer patients with EGFR tyrosine kinase inhibitors (TKI), all patients eventually acquire resistance to…”
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NeoScore Integrates Characteristics of the Neoantigen:MHC Class I Interaction and Expression to Accurately Prioritize Immunogenic Neoantigens by Borden, Elizabeth S, Ghafoor, Suhail, Buetow, Kenneth H, LaFleur, Bonnie J, Wilson, Melissa A, Hastings, K Taraszka

“…Accurate prioritization of immunogenic neoantigens is key to developing personalized cancer vaccines and distinguishing those patients likely to respond to…”
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The Application of Exercise Training for Diabetic Peripheral Neuropathy by Holmes, Clifton J., Hastings, Mary K.

“…Diabetic peripheral neuropathy (DPN) is the presence of symptoms and/or signs of peripheral nerve dysfunction in people with diabetes after the exclusion of…”
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GILT Modulates CD4+ T-Cell Tolerance to the Melanocyte Differentiation Antigen Tyrosinase-Related Protein 1 by Rausch, Matthew P., Taraszka Hastings, K.

“…Gamma-IFN-inducible lysosomal thiol reductase (GILT) facilitates major histocompatibility complex class II-restricted processing through endocytic reduction of…”
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Spatial distribution, movements, and geographic range of Steller sea lions (Eumetopias jubatus) in Alaska by Jemison, Lauri A, Pendleton, Grey W, Hastings, Kelly K, Maniscalco, John M, Fritz, Lowell W

“…The two stocks of Steller sea lions (Eumetopias jubatus) in Alaska include an endangered western stock, recently recovering in parts of its range following…”
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Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC by Amato, Katherine R, Wang, Shan, Hastings, Andrew K, Youngblood, Victoria M, Santapuram, Pranav R, Chen, Haiying, Cates, Justin M, Colvin, Daniel C, Ye, Fei, Brantley-Sieders, Dana M, Cook, Rebecca S, Tan, Li, Gray, Nathanael S, Chen, Jin

“…Genome-wide analyses determined previously that the receptor tyrosine kinase (RTK) EPHA2 is commonly overexpressed in non-small cell lung cancers (NSCLCs)…”
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Human Achilles tendon mechanical behavior is more strongly related to collagen disorganization than advanced glycation end-products content by Zellers, Jennifer A., Eekhoff, Jeremy D., Walk, Remy E., Hastings, Mary K., Tang, Simon Y., Lake, Spencer P.

“…Diabetes is associated with impaired tendon homeostasis and subsequent tendon dysfunction, but the mechanisms underlying these associations is unclear…”
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Aedes aegypti SNAP and a calcium transporter ATPase influence dengue virus dissemination by Marin-Lopez, Alejandro, Jiang, Junjun, Wang, Yuchen, Cao, Yongguo, MacNeil, Tyler, Hastings, Andrew K, Fikrig, Erol

“…Dengue virus (DENV) is a flavivirus that causes marked human morbidity and mortality worldwide, and is transmitted to humans by Aedes aegypti mosquitoes…”
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High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma by Buetow, Kenneth H, Meador, Lydia R, Menon, Hari, Lu, Yih-Kuang, Brill, Jacob, Cui, Haiyan, Roe, Denise J, DiCaudo, David J, Hastings, K Taraszka

“…The MHC class I Ag presentation pathway in melanoma cells has a well-established role in immune-mediated destruction of tumors. However, the clinical…”
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A Broadly Neutralizing Human Monoclonal Antibody Exhibits In Vivo Efficacy Against Both Human Metapneumovirus and Respiratory Syncytial Virus by Schuster, Jennifer E., Cox, Reagan G., Hastings, Andrew K., Boyd, Kelli L., Wadia, Jay, Chen, Zhifeng, Burton, Dennis R., Williamson, R. Anthony, Williams, John V.

“…Background. Human metapneumovirus (HMPV) is a leading cause of acute respiratory tract infection, with significant morbidity and mortality. No licensed…”
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Altered vector competence in an experimental mosquito-mouse transmission model of Zika infection by Uraki, Ryuta, Hastings, Andrew K, Gloria-Soria, Andrea, Powell, Jeffrey R, Fikrig, Erol

“…Few animal models of Zika virus (ZIKV) infection have incorporated arthropod-borne transmission. Here, we establish an Aedes aegypti mosquito model of ZIKV…”
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Giant boid snake from the Palaeocene neotropics reveals hotter past equatorial temperatures by Hastings, Alexander K, Herrera, Fabiany A, Polly, P. David, Bloch, Jonathan I, Cadena, Edwin A, Jaramillo, Carlos A, Head, Jason J, Bourque, Jason R

“…The largest extant snakes live in the tropics of South America and southeast Asia where high temperatures facilitate the evolution of large body sizes among…”
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Natal and breeding philopatry of female Steller sea lions in southeastern Alaska by Hastings, Kelly K, Jemison, Lauri A, Pendleton, Grey W, Raum-Suryan, Kimberly L, Pitcher, Kenneth W

“…Information on drivers of dispersal is critical for wildlife conservation but is rare for long-lived marine mammal species with large geographic ranges. We fit…”
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Epigenetic Control of Retrotransposon Expression in Human Embryonic Stem Cells by Macia, Angela, Muñoz-Lopez, Martin, Cortes, Jose Luis, Hastings, Robert K., Morell, Santiago, Lucena-Aguilar, Gema, Marchal, Juan Antonio, Badge, Richard M., Garcia-Perez, Jose Luis

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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