Search Results - "Hastings, Jordan F."

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis by Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.

“…The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their…”
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Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients by Fey, Dirk, Halasz, Melinda, Dreidax, Daniel, Kennedy, Sean P, Hastings, Jordan F, Rauch, Nora, Munoz, Amaya Garcia, Pilkington, Ruth, Fischer, Matthias, Westermann, Frank, Kolch, Walter, Kholodenko, Boris N, Croucher, David R

“…Signaling pathways control cell fate decisions that ultimately determine the behavior of cancer cells. Therefore, the dynamics of pathway activity may contain…”
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Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers by Croucher, David R, Iconomou, Mary, Hastings, Jordan F, Kennedy, Sean P, Han, Jeremy Z R, Shearer, Robert F, McKenna, Jessie, Wan, Adrian, Lau, Joseph, Aparicio, Samuel, Saunders, Darren N

“…The dynamic assembly of multiprotein complexes is a central mechanism of many cell signaling pathways. This process is key to maintaining the spatiotemporal…”
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A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma by Gonzalez Rajal, Alvaro, Marzec, Kamila A, McCloy, Rachael A, Nobis, Max, Chin, Venessa, Hastings, Jordan F, Lai, Kaitao, Kennerson, Marina, Hughes, William E, Vaghjiani, Vijesh, Timpson, Paul, Cain, Jason E, Watkins, D Neil, Croucher, David R, Burgess, Andrew

“…We previously used a pulse-based assay to unveil targetable signalling pathways associated with innate cisplatin resistance in lung adenocarcinoma (Hastings et…”
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Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer by Kennedy, Sean P, Han, Jeremy Z R, Portman, Neil, Nobis, Max, Hastings, Jordan F, Murphy, Kendelle J, Latham, Sharissa L, Cadell, Antonia L, Miladinovic, Dushan, Marriott, Gabriella R, O'Donnell, Yolande E I, Shearer, Robert F, Williams, James T, Munoz, Amaya Garcia, Cox, Thomas R, Watkins, D Neil, Saunders, Darren N, Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David R

“…The oncogenic receptor tyrosine kinase (RTK) ERBB2 is known to dimerize with other EGFR family members, particularly ERBB3, through which it potently activates…”
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The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family by Kennedy, Sean P, Hastings, Jordan F, Han, Jeremy Z R, Croucher, David R

“…Each member of the epidermal growth factor receptor (EGFR) family plays a key role in normal development, homeostasis, and a variety of pathophysiological…”
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Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma by Hastings, Jordan F, Gonzalez Rajal, Alvaro, Latham, Sharissa L, Han, Jeremy Zr, McCloy, Rachael A, O'Donnell, Yolande Ei, Phimmachanh, Monica, Murphy, Alexander D, Nagrial, Adnan, Daneshvar, Dariush, Chin, Venessa, Watkins, D Neil, Burgess, Andrew, Croucher, David R

“…The identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has previously been hampered by…”
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Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover by Raftopulos, Nikki L, Washaya, Tinashe C, Niederprüm, Andreas, Egert, Antonia, Hakeem-Sanni, Mariam F, Varney, Bianca, Aishah, Atqiya, Georgieva, Mariya L, Olsson, Ellinor, Dos Santos, Diandra Z, Nassar, Zeyad D, Cochran, Blake J, Nagarajan, Shilpa R, Kakani, Meghna S, Hastings, Jordan F, Croucher, David R, Rye, Kerry-Anne, Butler, Lisa M, Grewal, Thomas, Hoy, Andrew J

“…Prostate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating androgens. However,…”
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Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma by Gonzalez-Rajal, Alvaro, Hastings, Jordan F, Watkins, D Neil, Croucher, David R, Burgess, Andrew

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The extracellular matrix as a key regulator of intracellular signalling networks by Hastings, Jordan F, Skhinas, Joanna N, Fey, Dirk, Croucher, David R, Cox, Thomas R

“…The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This complex, acellular entity is composed of hundreds of individual…”
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Applications of personalised signalling network models in precision oncology by Hastings, Jordan F., O'Donnell, Yolande E.I., Fey, Dirk, Croucher, David R.

“…As our ability to provide in-depth, patient-specific characterisation of the molecular alterations within tumours rapidly improves, it is becoming apparent…”
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Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer by Lin, Hui-Ming, Yeung, Nicole, Hastings, Jordan F., Croucher, David R., Huynh, Kevin, Meikle, Thomas G., Mellett, Natalie A., Kwan, Edmond M., Davis, Ian D., Tran, Ben, Mahon, Kate L., Zhang, Alison, Stockler, Martin R., Briscoe, Karen, Marx, Gavin, Bastick, Patricia, Crumbaker, Megan L., Joshua, Anthony M., Azad, Arun A., Meikle, Peter J., Horvath, Lisa G.

“…Circulating lipids or cytokines are associated with prognosis in metastatic castration-resistant prostate cancer (mCRPC). This study aimed to understand the…”
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Personalized Medicine for Neuroblastoma: Moving from Static Genotypes to Dynamic Simulations of Drug Response by Han, Jeremy Z R, Hastings, Jordan F, Phimmachanh, Monica, Fey, Dirk, Kolch, Walter, Croucher, David R

“…High-risk neuroblastoma is an aggressive childhood cancer that is characterized by high rates of chemoresistance and frequent metastatic relapse. A number of…”
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Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma by Hastings, Jordan F, Latham, Sharissa L, Kamili, Alvin, Wheatley, Madeleine S, Han, Jeremy Z R, Wong-Erasmus, Marie, Phimmachanh, Monica, Nobis, Max, Pantarelli, Chiara, Cadell, Antonia L, O'Donnell, Yolande E I, Leong, King Ho, Lynn, Sophie, Geng, Fan-Suo, Cui, Lujing, Yan, Sabrina, Achinger-Kawecka, Joanna, Stirzaker, Clare, Norris, Murray D, Haber, Michelle, Trahair, Toby N, Speleman, Frank, De Preter, Katleen, Cowley, Mark J, Bogdanovic, Ozren, Timpson, Paul, Cox, Thomas R, Kolch, Walter, Fletcher, Jamie I, Fey, Dirk, Croucher, David R

“…Gene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare cancer cells. However, we now…”
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Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification (BiCAP) by Hastings, Jordan F, Han, Jeremy Z R, Shearer, Robert F, Kennedy, Sean P, Iconomou, Mary, Saunders, Darren N, Croucher, David R

“…The assembly of protein complexes is a central mechanism underlying the regulation of many cell signaling pathways. A major focus of biomedical research is…”
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Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification (BiCAP) by Hastings, Jordan F., Han, Jeremy Z.R., Shearer, Robert F., Kennedy, Sean P., Iconomou, Mary, Saunders, Darren N., Croucher, David R.

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Abstract CN05-03: Personalized cancer diagnostics and therapeutics based on the computational modeling of signal transduction networks by Kolch, Walter, Fey, Dirk, Halasz, Melinda, Rauch, Nora, Munoz, Amaya Garcia, Pilkington, Ruth, Kholodenko, Boris N., Croucher, David R., Kennedy, Sean P., Hastings, Jordan F., Westermann, Frank, Dreidax, Daniel, Fischer, Matthias, Duffy, David, Krstic, Aleksandar, Schwarzl, Thomas

“…Abstract Signalling pathways exert finely tuned control over cell fate decisions that ultimately determine the behaviour of cancer cells. It could therefore be…”
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