Search Results - "Hasson, Sam"

Effect of RGT-61159 on inhibition of oncogene c-MYB synthesis and tumor growth inhibition in a broad range of ACC PDX models, at well tolerated doses in rodents and non-human primates by Xi, Simon, Soulard, Patricia, Li, Kai, Gu, Xiubin, Kay, Ibrahim, Hasson, Sam, Yates, Chris, Sadlish, Heather, Lee, Jay, Weng, Zhiping, Xu, Simon, Wager, Travis

“…6107 Background: RGT-61159 is a first in-class oral inhibitor of the oncogenic transcription factor c-MYB via selective alteration of its RNA splicing…”
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Abstract 3306: RGT-M001, a first-in-class small molecule mRNA degrader of the oncogenic transcription factor c-Myb, demonstrated remarkable single agent anti-tumor efficacy in cancer patient-derived xenograft model by Lu, Norman, Soulard, Patricia, Li, Kay, Sadlish, Heather, Yates, Chris, Gu, Xiubin, Kays, Ibrahim, Lee, Jae, Hasson, Sam, Weng, Zhiping, Xi, Simon, Wager, Travis

“…Dysregulated transcription factors (TFs) represent a unique class of drug targets that drive aberrant gene expression programs involved in the major hallmarks…”
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Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III by Iben, James R., Mazeika, Julie K., Hasson, Sam, Rijal, Keshab, Arimbasseri, Aneeshkumar G., Russo, Amy N., Maraia, Richard J.

“…RNA polymerase III recognizes and pauses at its terminator, an oligo(dT) tract in non-template DNA, terminates 3′ oligo(rU) synthesis within this sequence, and…”
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