Search Results - "Hassler, Luise"

Potential SARS-CoV-2 kidney infection and paths to injury by Hassler, Luise, Batlle, Daniel

“…Although direct kidney infection by SARS-CoV-2 remains controversial, a study based largely on autopsies shows increased tubulointerstitial fibrosis in…”
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A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection by Hassler, Luise, Wysocki, Jan, Gelarden, Ian, Sharma, Isha, Tomatsidou, Anastasia, Ye, Minghao, Gula, Haley, Nicoleascu, Vlad, Randall, Glenn, Pshenychnyi, Sergii, Khurram, Nigar, Kanwar, Yashpal, Missiakas, Dominique, Henkin, Jack, Yeldandi, Anjana, Batlle, Daniel

“…Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2) as a main receptor to enter target…”
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On the essentiality of the angiotensin converting enzyme 2 receptor for SARS‐CoV‐2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID‐19 by Hassler, Luise, Penninger, Josef, Batlle, Daniel

“…Normally, human organoids, like human and monkey cell lines, can be easily infected with SARS-CoV-2 when they expre both ACE2 as well as TMPRSS2, one of the…”
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Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant by Cianfarini, Cosimo, Hassler, Luise, Wysocki, Jan, Hassan, Abdelsabour, Nicolaescu, Vlad, Elli, Derek, Gula, Haley, Ibrahim, Amany M, Randall, Glenn, Henkin, Jack, Batlle, Daniel

“…Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme 2 (ACE2) as its main receptor for cell entry. We…”
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Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting by Lin, Hui, Geurts, Frank, Hassler, Luise, Batlle, Daniel, Mirabito Colafella, Katrina M., Denton, Kate M., Zhuo, Jia L., Li, Xiao C., Ramkumar, Nirupama, Koizumi, Masahiro, Matsusaka, Taiji, Nishiyama, Akira, Hoogduijn, Martin J., Hoorn, Ewout J., Danser, A.H. Jan

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Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19 by Hassler, Luise, Reyes, Fabiola, Sparks, Matthew A, Welling, Paul, Batlle, Daniel

“…Despite evidence of multiorgan tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with coronavirus disease 2019 (COVID-19),…”
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A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids by Wysocki, Jan, Ye, Minghao, Hassler, Luise, Gupta, Ashwani Kumar, Wang, Yuguo, Nicoleascu, Vlad, Randall, Glenn, Wertheim, Jason A, Batlle, Daniel

“…There is an urgent need for approaches to prevent and treat SARS-CoV-2 infection. Administration of soluble ACE2 protein acting as a decoy to bind to…”
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Neutralization of the Omicron Variant of SARS-CoV-2 Is Effective by a Human and a Mouse Soluble ACE2 Protein: FR-PO015 by Hassler, Luise, Nicolaescu, Vlad I., Wysocki, Jan, Randall, Glenn, Batlle, Daniel

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ACE2 and TMPRSS2 Co-Localization in Proximal Tubules from Human Kidneys Obtained at Autopsy from COVID-19 Patients: PO0011 by Ellis, Carla L., Ye, Minghao, Hassler, Luise, Baig, Athar, Wysocki, Jan, Batlle, Daniel

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Lack of Evidence for Kidney Invasion by SARS-CoV-2 in a Lethal Mouse Model: FR-PO020 by Syed, Mariya, Cianfarini, Cosimo L., Hassler, Luise, Ye, Minghao, Wysocki, Jan, Kanwar, Yashpal S., Missiakas, Dominique, Randall, Glenn, Batlle, Daniel

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AKI in a Mouse Model of COVID-19: Therapeutic Potential of a Novel Soluble ACE2 Variant: PO0008 by Hassler, Luise, Wysocki, Jan, Tomatsidou, Anastasia, Gula, Haley, Nicolaescu, Vlad I., Sharma, Isha, Randall, Glenn, Kanwar, Yashpal S., Batlle, Daniel

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A Novel Soluble ACE2 Protein Protects from Lethal SARS-CoV-2 Infection: SA-OR04 by Hassler, Luise, Wysocki, Jan, Gelarden, Ian A., Tomatsidou, Anastasia, Gula, Haley, Nicolaescu, Vlad I., Randall, Glenn, Yeldandi, Anjana, Batlle, Daniel

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Abstract 12853: Superiority of Intranasal Over Systemic Administration of a Soluble ACE2 Protein (ACE2 618-DDC-ABD) in SARS-CoV-2 Infected Mice by Hassler, Luise, Wysocki, Jan A, Gelarden, Ian, Khurram, Nigar, Nicolaescu, Vlad, Tomatsidou, Anastasia, Gula, Haley, Randall, Glenn, Missiakas, Dominique, Henkin, Jack, Battle, Daniel C

“…Introduction and Hypothesis. Our group and others are using soluble ACE2 proteins to combat SARS-CoV-2. We have previously reported prevention of mortality,…”
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Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity by Batlle, Daniel, Monteil, Vanessa, Garreta, Elena, Hassler, Luise, Wysocki, Jan, Chandar, Vasuretha, Schwartz, Robert E., Mirazimi, Ali, Montserrat, Nuria, Bader, Michael, Penninger, Josef M.

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Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting by Lin, Hui, Geurts, Frank, Hassler, Luise, Batlle, Daniel, Mirabito Colafella, Katrina M, Denton, Kate M, Zhuo, Jia L, Li, Xiao C, Ramkumar, Nirupama, Koizumi, Masahiro, Matsusaka, Taiji, Nishiyama, Akira, Hoogduijn, Martin J, Hoorn, Ewout J, Danser, A H Jan

“…The concept of local formation of angiotensin II in the kidney has changed over the last 10-15 years. Local synthesis of angiotensinogen in the proximal tubule…”
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Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection by Hassler, Luise, Wysocki, Jan, Ahrendsen, Jared T, Ye, Minghao, Gelarden, Ian, Nicolaescu, Vlad, Tomatsidou, Anastasia, Gula, Haley, Cianfarini, Cosimo, Forster, Peter, Khurram, Nigar, Singer, Benjamin D, Randall, Glenn, Missiakas, Dominique, Henkin, Jack, Batlle, Daniel

“…A soluble ACE2 protein bioengineered for long duration of action and high affinity to SARS-CoV-2 was administered either intranasally (IN) or intraperitoneally…”
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Das Ideal Eines Lehrers des Deutschen in Amerika by Haessler, Luise

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