Search Results - "Hassler, Daniel F"

Distinct Concentration-Dependent Effects of the Polo-like Kinase 1―Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis by GILMARTIN, Aidan G, BLEAM, Maureen R, SUTTON, David, DIAMOND, Melody A, JACKSON, Jeffrey R, LAQUERRE, Sylvie G, RICHTER, Mark C, ERSKINE, Symon G, KRUGER, Ryan G, MADDEN, Lenore, HASSLER, Daniel F, SMITH, Gary K, GONTAREK, Richard R, COURTNEY, Mary P

“…Polo-like kinase 1 (Plk1) is a conserved serine/threonine kinase that plays an essential role in regulating the many processes involved in mitotic entry and…”
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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1 by Lansing, Timothy J, McConnell, Randy T, Duckett, Derek R, Spehar, Glenn M, Knick, Victoria B, Hassler, Daniel F, Noro, Nobuhiro, Furuta, Masaaki, Emmitte, Kyle A, Gilmer, Tona M, Mook, Jr, Robert A, Cheung, Mui

“…Polo-like kinase 1 (PLK1) plays key roles in the regulation of mitotic progression, including mitotic entry, spindle formation, chromosome segregation, and…”
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Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase by Luberto, Chiara, Hassler, Daniel F, Signorelli, Paola, Okamoto, Yasuo, Sawai, Hirofumi, Boros, Eric, Hazen-Martin, Debra J, Obeid, Lina M, Hannun, Yusuf A, Smith, Gary K

“…A high throughput screen for neutral, magnesium-dependent sphingomyelinase (SMase) was performed. One inhibitor discovered in the screen, GW4869, functioned as…”
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Discovery of thiophene inhibitors of polo-like kinase by Emmitte, Kyle A., Andrews, C. Webb, Badiang, Jennifer G., Davis-Ward, Ronda G., Dickson, Hamilton D., Drewry, David H., Emerson, Holly K., Epperly, Andrea H., Hassler, Daniel F., Knick, Victoria B., Kuntz, Kevin W., Lansing, Timothy J., Linn, James A., Mook, Robert A., Nailor, Kristen E., Salovich, James M., Spehar, Glenn M., Cheung, Mui

“…The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a…”
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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding by EMMITTE, Kyle A, ADJEBANG, George M, JACKSON, Jeffrey R, KUNTZ, Kevin W, LANSING, Timothy J, MOOK, Robert A, NAILOR, Kristen E, POBANZ, Mark A, SMITH, Stephon C, SUNG, Chiu-Mei, CHEUNG, Mui, WEBB ANDREWS, C, BADIANG ALBERTI, Jennifer G, BAMBAL, Ramesh, CHAMBERLAIN, Stanley D, DAVIS-WARD, Ronda G, DICKSON, Hamilton D, HASSLER, Daniel F, HORNBERGER, Keith R

“…A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality…”
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Orally active 4-amino-5-diarylurea-furo[2,3- d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2 by Miyazaki, Yasushi, Tang, Jun, Maeda, Yutaka, Nakano, Masato, Wang, Liping, Nolte, Robert T., Sato, Hideyuki, Sugai, Masaki, Okamoto, Yuji, Truesdale, Anne T., Hassler, Daniel F., Nartey, Eldridge N., Patrick, Denis R., Ho, Maureen L., Ozawa, Kazunori

“…Dual VEGFR2 and Tie-2 inhibitors as anti-angiogenic agents were identified. Compound 8a exhibited strong inhibitory activities against VEGFR2 and Tie-2 in both…”
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Purification and Characterization of a Membrane Bound Neutral pH Optimum Magnesium-dependent and Phosphatidylserine-stimulated Sphingomyelinase from Rat Brain by Liu, B, Hassler, D F, Smith, G K, Weaver, K, Hannun, Y A

“…Sphingomyelin hydrolysis and ceramide generation catalyzed by sphingomyelinases (SMase) are key components of the signaling pathways in cytokine- and…”
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Corrigendum to “Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding” [Bioorg. Med. Chem. Lett. 19 (2009) 1694] by Emmitte, Kyle A., Adjabeng, George M., Webb Andrews, C., Badiang Alberti, Jennifer G., Bambal, Ramesh, Chamberlain, Stanley D., Davis-Ward, Ronda G., Dickson, Hamilton D., Hassler, Daniel F., Hornberger, Keith R., Jackson, Jeffrey R., Kuntz, Kevin W., Lansing, Timothy J., Mook, Robert A., Nailor, Kristen E., Pobanz, Mark A., Smith, Stephon C., Sung, Chiu-Mei, Cheung, Mui

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A high throughput sphingomyelinase assay by Hassler, D F, Laethem, R M, Smith, G K

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