Search Results - "Hassinen, Ilmo E"

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen‐containing bisphosphonates by Mönkkönen, Hannu, Auriola, Seppo, Lehenkari, Petri, Kellinsalmi, Maarit, Hassinen, Ilmo E, Vepsäläinen, Jouko, Mönkkönen, Jukka

“…Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess bone resorption. On the basis of…”
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Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury by Hyvärinen, Jaana, Hassinen, Ilmo E., Sormunen, Raija, Mäki, Joni M., Kivirikko, Kari I., Koivunen, Peppi, Myllyharju, Johanna

“…Hypoxia-inducible factor (HIF) has a pivotal role in oxygen homeostasis and cardioprotection mediated by ischemic preconditioning. Its stability is regulated…”
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Association between mitochondrial DNA haplogroups J and K, serum branched-chain amino acids and lowered capability for endurance exercise by Kiiskilä, Jukka M, Hassinen, Ilmo E, Kettunen, Johannes, Kytövuori, Laura, Mikkola, Ilona, Härkönen, Pirjo, Jokelainen, Jari J, Keinänen-Kiukaanniemi, Sirkka, Perola, Markus, Majamaa, Kari

“…Endurance exercise training promotes the catabolism of branched-chain amino acids (BCAAs) in skeletal muscles. We have previously shown that mitochondrial DNA…”
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Leber hereditary optic neuropathy mutations in the ND6 subunit of mitochondrial complex I affect ubiquinone reduction kinetics in a bacterial model of the enzyme by Pätsi, Jukka, Kervinen, Marko, Finel, Moshe, Hassinen, Ilmo E

“…LHON (Leber hereditary optic neuropathy) is a maternally inherited disease that leads to sudden loss of central vision at a young age. There are three common…”
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Superoxide production during ischemia–reperfusion in the perfused rat heart: A comparison of two methods of measurement by Näpänkangas, Juha P, Liimatta, Erkki V, Joensuu, Päivi, Bergmann, Ulrich, Ylitalo, Kari, Hassinen, Ilmo E

“…Abstract Reactive oxygen species (ROS) have been implicated in many aspects of tissue/cellular metabolic signaling and pathology, including cardioprotection…”
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Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite by Lehenkari, Petri P, Kellinsalmi, Maarit, Näpänkangas, Juha P, Ylitalo, Kari V, Mönkkönen, Jukka, Rogers, Michael J, Azhayev, Alex, Väänänen, H Kalervo, Hassinen, Ilmo E

“…Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess bone resorption. Recent studies…”
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Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse by Chen, Zhijun, Leskinen, Hanna, Liimatta, Erkki, Sormunen, Raija T, Miinalainen, Ilkka J, Hassinen, Ilmo E, Hiltunen, J Kalervo

“…It has been recently recognized that mammalian mitochondria contain most, if not all, of the components of fatty acid synthesis type II (FAS II). Among the…”
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Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates: POSSIBLE LINKS BETWEEN CELL METABOLISM AND STABILIZATION OF HIF by Koivunen, Peppi, Hirsilä, Maija, Remes, Anne M, Hassinen, Ilmo E, Kivirikko, Kari I, Myllyharju, Johanna

“…The stability and transcriptional activity of the hypoxia-inducible factors (HIFs) are regulated by two oxygen-dependent events that are catalyzed by three HIF…”
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Cardiac abnormalities in patients with mitochondrial DNA mutation 3243A>G by Majamaa-Voltti, Kirsi, Peuhkurinen, Keijo, Kortelainen, Marja-Leena, Hassinen, Ilmo E, Majamaa, Kari

“…Tissues that depend on aerobic energy metabolism suffer most in diseases caused by mutations in mitochondrial DNA (mtDNA). Cardiac abnormalities have been…”
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Intracellular Free Calcium and Mitochondrial Membrane Potential in Ischemia/Reperfusion and Preconditioning by Ylitalo, Kari V, Ala-Rämi, Antti, Liimatta, Erkki V, Peuhkurinen, Keijo J, Hassinen, Ilmo E

“…Moderation of calcium perturbations has been implicated in ischemic preconditioning. As mitochondria possess an effective Ca2+transporting system driven by the…”
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Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy by Karpanen, Terhi, Bry, Maija, Ollila, Hanna M, Seppänen-Laakso, Tuulikki, Liimatta, Erkki, Leskinen, Hanna, Kivelä, Riikka, Helkamaa, Teemu, Merentie, Mari, Jeltsch, Michael, Paavonen, Karri, Andersson, Leif C, Mervaala, Eero, Hassinen, Ilmo E, Ylä-Herttuala, Seppo, Orešič, Matej, Alitalo, Kari

“…Vascular endothelial growth factor (VEGF)-B is poorly angiogenic but prominently expressed in metabolically highly active tissues, including the heart. We…”
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From identification of fluorescent flavoproteins to mitochondrial redox indicators in intact tissues by Hassinen, Ilmo E.

“…Development of the use of flavin and nicotinamide-adenine nucleotide fluorescence in monitoring the redox state of the free mitochondrial NADH/NAD+ couple in…”
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Myocardial glucose uptake in patients with the m.3243A > G mutation in mitochondrial DNA by Lindroos, Markus M., Pärkkä, Jussi P., Taittonen, Markku T., Iozzo, Patricia, Kärppä, Mikko, Hassinen, Ilmo E., Knuuti, Juhani, Nuutila, Pirjo, Majamaa, Kari

“…Mitochondrial mutations impair glucose oxidation and increase glucose uptake in cell cultures and lead to cardiomyopathy in patients. Here we characterize…”
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Effects of pathogenic mutations in membrane subunits of mitochondrial Complex I on redox activity and proton translocation studied by modeling in Escherichia coli by Pätsi, Jukka, Kervinen, Marko, Kytövuori, Laura, Majamaa, Kari, Hassinen, Ilmo E

“…Effects of Complex I mutations were studied by modeling in NuoH, NuoJ or NuoK subunits of Escherichia coli NDH-1 by simultaneous optical monitoring of…”
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LHON/MELAS overlap mutation in ND1 subunit of mitochondrial complex I affects ubiquinone binding as revealed by modeling in Escherichia coli NDH-1 by Pätsi, Jukka, Maliniemi, Pilvi, Pakanen, Salla, Hinttala, Reetta, Uusimaa, Johanna, Majamaa, Kari, Nyström, Thomas, Kervinen, Marko, Hassinen, Ilmo E.

“…Defects in complex I due to mutations in mitochondrial DNA are associated with clinical features ranging from single organ manifestation like Leber hereditary…”
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Homozygous W748S mutation in the POLG1 gene in patients with juvenile‐onset Alpers syndrome and status epilepticus by Uusimaa, Johanna, Hinttala, Reetta, Rantala, Heikki, Päivärinta, Markku, Herva, Riitta, Röyttä, Matias, Soini, Heidi, Moilanen, Jukka S., Remes, Anne M., Hassinen, Ilmo E., Majamaa, Kari

“…Summary Purpose: Polymerase gamma (POLG) is the sole enzyme in the replication of mitochondrial DNA (mtDNA). Numerous mutations in the POLG1 gene have been…”
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Evaluating clinical mitochondrial respiratory chain enzymes from biopsy specimens presenting skewed probability distribution of activity data by Hautakangas, Milla-Riikka, Hinttala, Reetta, Rantala, Heikki, Nieminen, Pentti, Uusimaa, Johanna, Hassinen, Ilmo E

“…Due to the relative rarity of mitochondrial diseases, generating reference ranges is problematic in evaluation of respiratory chain activities particularly in…”
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Modeling of human pathogenic mutations in Escherichia coli complex I reveals a sensitive region in the fourth inside loop of NuoH by Maliniemi, Pilvi, Kervinen, Marko, Hassinen, Ilmo E

“…Seven of the 45 subunits of mitochondrial NADH:ubiquinone oxidoreductase (complex I) are mitochondrially encoded and have been shown to harbor pathogenic…”
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The MELAS mutations 3946 and 3949 perturb the critical structure in a conserved loop of the ND1 subunit of mitochondrial complex I by Kervinen, Marko, Hinttala, Reetta, Helander, Heli M., Kurki, Sari, Uusimaa, Johanna, Finel, Moshe, Majamaa, Kari, Hassinen, Ilmo E.

“…The ND1 subunit gene of the mitochondrial NADH-ubiquinone oxidoreductase (complex I) is a hot spot for mutations causing Leber hereditary optic neuropathy and…”
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Mitochondrial function determines the viability and osteogenic potency of human mesenchymal stem cells by Pietilä, Mika, Lehtonen, Siri, Närhi, Marko, Hassinen, Ilmo E, Leskelä, Hannu-Ville, Aranko, Kari, Nordström, Katrina, Vepsäläinen, Ari, Lehenkari, Petri

“…Advanced therapies medicinal products (ATMPs) have introduced innovative cell-based products. However, the regulatory demands for characterization of ATMPs are…”
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