Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial

Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial

Rationale We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. Objectives The aim of this study was to evaluate the effect of Valeriana officinalis root e...

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Bibliographic Details
Published in:Psychopharmacology Vol. 232; no. 5; pp. 843 - 850
Main Authors: Hassani, Soghra, Alipour, Abbas, Darvishi Khezri, Hadi, Firouzian, Abolfazl, Emami Zeydi, Amir, Gholipour Baradari, Afshin, Ghafari, Rahman, Habibi, Wali-allah, Tahmasebi, Homeyra, Alipour, Fatemeh, Ebrahim Zadeh, Pooneh
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2015
Springer
Springer Nature B.V
Subjects:
Adult
Aged
Analysis
Biomedical and Life Sciences
Biomedicine
Care and treatment
Cognition & reasoning
Cognition - drug effects
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognition Disorders - prevention & control
Cognitive disorders
Complications and side effects
Coronary artery bypass
Coronary Artery Bypass - adverse effects
Coronary Artery Bypass - psychology
Diagnosis
Double-Blind Method
Female
Heart surgery
Herbal medicine
Hospital rates
Humans
Iran
Male
Management
Middle Aged
Mortality
Neuropsychological Tests
Neurosciences
Original Investigation
Pharmacology/Toxicology
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Prevention
Psychiatry
Psychopharmacology
Risk factors
Treatment Outcome
Valerian
Iran
Coronary artery bypass grafting
Cognition disorder
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Summary:Rationale We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. Objectives The aim of this study was to evaluate the effect of Valeriana officinalis root extract on prevention of early postoperative cognitive dysfunction after on-pump CABG surgery. Methods In a randomized, double-blind, placebo-controlled trial, 61 patients, aged between 30 and 70 years, scheduled for elective CABG surgery using cardiopulmonary bypass (CPB), were recruited into the study. Patients were randomly divided into two groups who received either one valerian capsule containing 530 mg of valerian root extract (1,060 mg/daily) or placebo capsule each 12 h for 8 weeks, respectively. For all patients, cognitive brain function was evaluated before the surgery and at 10-day and 2-month follow-up by Mini Mental State Examination (MMSE) test. Results Mean MMSE score decreased from 27.03 ± 2.02 in the preoperative period to 26.52 ± 1.82 at the 10th day and then increased to 27.45 ± 1.36 at the 60th day in the valerian group. Conversely, its variation was reduced significantly after 60 days in the placebo group, 27.37 ± 1.87 at the baseline to 24 ± 1.91 at the 10th day, and consequently slightly increased to 24.83 ± 1.66 at the 60th day. Valerian prophylaxis reduced odds of cognitive dysfunction compared to placebo group (OR = 0.108, 95 % CI 0.022–0.545). Conclusion We concluded that, based on this study, the cognitive state of patients in the valerian group was better than that in the placebo group after CABG; therefore, it seems that the use of V. officinalis root extract may prevent early postoperative cognitive dysfunction after on-pump CABG surgery.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
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content type line 23
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-014-3716-x