Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt

Foot-and-mouth disease virus (FMDV) remains a major threat to livestock in Egypt, with ongoing outbreaks involving serotypes A, O, and SAT2. This study aimed to improve the understanding of these circulating FMDV strains to improve control measures. Between 2022 and 2023, 134 cattle samples from acr...

Full description

Saved in:

Bibliographic Details
Published in:	Current microbiology Vol. 81; no. 12; p. 435
Main Authors:	Hassanein, Rabab T., Abdelmegeed, Hala K., Abdelwahed, Dina A., Zaki, Abeer G., Saad, Alaa S., Shahein, Momtaz A., Afify, Ahmed F., Rohaim, Mohammed A.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-12-2024 Springer Nature B.V
Subjects:	Amino acids Animals Biomedical and Life Sciences Biotechnology Capsid Proteins - genetics Cattle Cattle Diseases - epidemiology Cattle Diseases - virology Disease Outbreaks Egypt - epidemiology Epidemiology Foot & mouth disease Foot-and-Mouth Disease - epidemiology Foot-and-Mouth Disease - virology Foot-and-Mouth Disease Virus - classification Foot-and-Mouth Disease Virus - genetics Foot-and-Mouth Disease Virus - immunology Foot-and-Mouth Disease Virus - isolation & purification Genetic analysis Life Sciences Livestock Microbiology Outbreaks Phylogeny Serogroup Serotypes Strains (organisms) Vaccine efficacy Vaccines VP1 protein Egypt
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Foot-and-mouth disease virus (FMDV) remains a major threat to livestock in Egypt, with ongoing outbreaks involving serotypes A, O, and SAT2. This study aimed to improve the understanding of these circulating FMDV strains to improve control measures. Between 2022 and 2023, 134 cattle samples from across Egypt were analyzed, revealing a 67.9% positivity rate for Pan FMDV. Of these positive samples, 64 were identified as serotype A and 27 as serotype O. Genetic analysis indicated that serotype O strains clustered within the EA-3 topotype, suggesting endemic persistence and potential vaccine evasion, while serotype A strains were associated with the African topotype and linked to regions such as Ethiopia, Kenya, and Sudan. Notable amino acid mutations in the VP1 protein of both serotypes highlighted potential challenges to vaccine effectiveness. These findings underscore the need for enhanced surveillance, timely vaccine updates, and regional cooperation to effectively manage FMD outbreaks in Egypt and neighboring countries.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0343-8651 1432-0991 1432-0991
DOI:	10.1007/s00284-024-03944-x