Search Results - "Hassan, Rasha A"

Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers by Kassab, Asmaa E., Gedawy, Ehab M., Hamed, Mohammed I. A., Doghish, Ahmed S., Hassan, Rasha A.

“…Novel tolmetin derivatives 5a-f to 8a-c were designed, synthesised, and evaluated for antiproliferative activity by NCI (USA) against a panel of 60 tumour cell…”
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Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity by Sonousi, Amr, Hassan, Rasha A., Osman, Eman O., Abdou, Amr M., Emam, Soha H.

“…Nineteen new quinazolin-4(3H)-one derivatives 3a-g and 6a-l were designed and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised…”
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Recent updates on thienopyrimidine derivatives as anticancer agents by Sayed, Menna Tallah M., Hassan, Rasha A., Halim, Peter A., El-Ansary, Afaf K.

“…Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds. They are important and widely represented in medicinal chemistry as they…”
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Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer by Halim, Peter A., Hassan, Rasha A., Mohamed, Khaled O., Hassanin, Soha O., Khalil, Mona G., Abdou, Amr M., Osman, Eman O.

“…Novel halogenated phenoxychalcones 2a-f and their corresponding N-acetylpyrazolines 3a-f were synthesised and evaluated for their anticancer activities against…”
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Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of PI3K/AKT/mTOR signaling pathway by Seif, Safaa E., Mahmoud, Zeinab, Wardakhan, Wagnat W., Abdou, Amr M., Hassan, Rasha A.

“…New thieno[2,3‐d]pyrimidine derivatives were designed and synthesized. The National Cancer Institute (NCI) evaluated the synthesized novel compounds against a…”
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Design, ecofriendly synthesis, anticancer and antimicrobial screening of innovative Biginelli dihydropyrimidines using β-aroylpyruvates as synthons by El-Malah, Afaf, Mahmoud, Zeinab, Hamed Salem, Heba, Abdou, Amr M., Soliman, Mona M. H., Hassan, Rasha A.

“…New ecofriendly Biginelli reaction procedures have been adapted to prepare new dihydropyrimidines (DHPMs) using a multicomponent one-pot reaction. All the…”
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Bio_Fabricated Levan Polymer from Bacillus subtilis MZ292983.1 with Antibacterial, Antibiofilm, and Burn Healing Properties by Hamada, Marwa A., Hassan, Rasha A., Abdou, Amr M., Elsaba, Yasmin M., Aloufi, Abeer S., Sonbol, Hana, Korany, Shereen M.

“…The biopolymer levan has sparked a lot of interest in commercial production and various industrial applications. In this study, a bacterial isolate with…”
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Useful four-carbon synthons en route to monastrol analogs by Abdou, Amr M., Botros, S., Hassan, Rasha A., Kamel, Mona M., Taber, Douglass F., Taher, Azza T.

“…A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were…”
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Novel thienopyrimidine-aminothiazole hybrids: Design, synthesis, antimicrobial screening, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and VEGFR-2 inhibition by El-Dash, Yara, Elzayat, Emad, Abdou, Amr M., Hassan, Rasha A.

“…[Display omitted] •A series of thienopyrimidine-aminothiazole hybrids 7a-j were designed as anticancer agents.•The anticancer activity of compounds was…”
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Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells by Emam, Soha H., Sonousi, Amr, Osman, Eman O., Hwang, Dukhyun, Kim, Gun-Do, Hassan, Rasha A.

“…[Display omitted] •Methoxylated and coumarin-based chalcones were designed as anti-inflammatory agents..•2f inhibits NO production in LPS-induced RAW264.7…”
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Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking by Hassan, Rasha A., Hamed, Mohammed I.A., Abdou, Amr M., El-Dash, Yara

“…[Display omitted] •A series of novel thieno[2,3-d]pyrimidine derivatives 3, 4a-d, 5a-c, 7a,b and 9a,b were designed as anticancer agents.•The anticancer…”
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Novel benzotriazole N-acylarylhydrazone hybrids: Design, synthesis, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and FAK inhibition by Kassab, Asmaa E., Hassan, Rasha A.

“…[Display omitted] •A series of benzotriazole N-acylarylhydrazone hybrids was synthesized.•The anticancer activity of the new hybrids was tested in…”
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New S‐substituted‐3‐phenyltetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one scaffold with promising anticancer activity profile through the regulation and inhibition of mutated B‐RAF signaling pathway by Seif, Safaa E., Wardakhan, Wagnat W., Hassan, Rasha A., Abdou, Amr M., Mahmoud, Zeinab

“…Novel 3‐phenyltetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives were synthesized and screened for their antiproliferative activity against a panel of 60…”
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Design, synthesis, biological evaluation, and docking studies of novel triazolo[4,3- b ]pyridazine derivatives as dual c-Met/Pim-1 potential inhibitors with antitumor activity by Mahmoud, Mohamed E, Ahmed, Eman M, Ragab, Hamdy M, Eltelbany, Rania Farag A, Hassan, Rasha A

“…Interest has been piqued in c-Met and Pim-1, potential new cancer treatment targets. A variety of triazolo[4,3- ]pyridazine derivatives were synthesized to…”
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Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity by Hassan, Rasha A., Emam, Soha H., Hwang, Dukhyun, Kim, Gun-Do, Hassanin, Soha O., Khalil, Mona G., Abdou, Amr M., Sonousi, Amr

“…[Display omitted] •Two series of pyrazoline compounds were designed and synthesized as antiproliferative agents by VEGFR pathway inhibition.•3f exhibited the…”
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Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone‐based derivatives as DHFR inhibitors by Osman, Eman O., Emam, Soha H., Sonousi, Amr, Kandil, Mai M., Abdou, Amr M., Hassan, Rasha A.

“…Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate reductase (DHFR) inhibitors. All compounds were evaluated for their…”
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Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities by Hassan, Rasha A., Hozayen, Walaa G., Abo Sree, Haidy T., Al-Muzafar, Hessah M., Amin, Kamal A., Ahmed, Osama M.

“…This study is aimed at evaluating the preventive effect and at suggesting the mode of actions of naringin and hesperidin and their combination in…”
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Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3-d]pyrimidine derivatives as EGFR inhibitors by Sayed, Menna Tallah M, Halim, Peter A, El-Ansary, Afaf K, Hassan, Rasha A

“…New series of 20 thieno[2,3-d]pyrimidine derivatives have been synthesized. The National Cancer Institute evaluated all the newly synthesized compounds for…”
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Design, Synthesis, and Molecular Docking of Novel Miscellaneous Chalcones as p38α Mitogen‐Activated Protein Kinase Inhibitors by Zeid, Mai M., El‐Badry, Osama M., Elmeligie, Salwa, Hassan, Rasha A.

“…New chalcones were synthesized and evaluated to serve as p38‐α type of mitogen‐activated protein kinase (MAPK) inhibitors. According to the National Cancer…”
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Synthesis, COX-2 inhibition, anti-inflammatory activity, molecular docking, and histopathological studies of new pyridazine derivatives by Ewieda, Sara Y., Hassan, Rasha A., Ahmed, Eman M., Abdou, Amr M., Hassan, Marwa S.A.

“…[Display omitted] •New pyridazine derivatives were synthesized and evaluated for their inhibitory activity against COX-1 and COX-2 enzymes.•Compounds 4c and 6b…”
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