Search Results - "Hassan, Imtaiyaz"
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Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
Published in Frontiers in oncology (10-03-2022)“…Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their…”
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Structure, function and applications of carbonic anhydrase isozymes
Published in Bioorganic & medicinal chemistry (15-03-2013)“…The carbonic anhydrases enzymes (CAs, EC 4.2.1.1) are zinc containing metalloproteins, which efficiently catalyse the reversible conversion of carbon dioxide…”
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SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions
Published in Molecular and cellular biochemistry (01-02-2021)“…The recent exposure of novel coronavirus strain, severe acute respiratory syndrome (SARS-CoV-2) has spread to different countries at an alarming rate. Faster…”
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Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy
Published in Bioscience reports (26-06-2020)“…Due to the lack of efficient therapeutic options and clinical trial limitations, the FDA-approved drugs can be a good choice to handle Coronavirus disease…”
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A novel multicopper oxidase (laccase) from cyanobacteria: Purification, characterization with potential in the decolorization of anthraquinonic dye
Published in PloS one (06-04-2017)“…A novel extracellular laccase enzyme produced from Spirulina platensis CFTRI was purified by ultrafiltration, cold acetone precipitation, anion exchange and…”
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Size-dependent studies of macromolecular crowding on the thermodynamic stability, structure and functional activity of proteins: in vitro and in silico approaches
Published in Biochimica et biophysica acta. General subjects (01-02-2017)“…The environment inside cells in which proteins fold and function are quite different from that of the dilute buffer solutions often used during in vitro…”
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Targeting Tau Hyperphosphorylation via Kinase Inhibition: Strategy to Address Alzheimer's Disease
Published in Current topics in medicinal chemistry (01-01-2020)“…Microtubule-associated protein tau is involved in the tubulin binding leading to microtubule stabilization in neuronal cells which is essential for…”
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Cooperative Unfolding of Residual Structure in Heat Denatured Proteins by Urea and Guanidinium Chloride
Published in PloS one (05-06-2015)“…The denatured states of proteins have always attracted our attention due to the fact that the denatured state is the only experimentally achievable state of a…”
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Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses
Published in Applied biochemistry and biotechnology (01-05-2014)“…Chemiluminescence (CL) is an important method for quantification and analysis of various macromolecules. A wide range of CL agents such as luminol, hydrogen…”
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Understanding the relationship between cerebellum and the frontal-cortex region of C9orf72-related amyotrophic lateral sclerosis: A comparative analysis of genetic features
Published in PloS one (16-05-2024)“…Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal neurodegenerative diseases for which at present no cure is available. Despite the…”
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A review of methods available to estimate solvent-accessible surface areas of soluble proteins in the folded and unfolded states
Published in Current protein & peptide science (01-01-2014)“…Solvent accessible surface area (SASA) of proteins has always been considered as a decisive factor in protein folding and stability studies. It is defined as…”
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12
FNDC5/Irisin: Physiology and Pathophysiology
Published in Molecules (Basel, Switzerland) (08-02-2022)“…A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart diseases, certain types of…”
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Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)
Published in Journal of biomolecular structure & dynamics (03-05-2019)“…Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential drug target for several complex diseases including cancer,…”
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Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
Published in International journal of molecular sciences (10-11-2021)“…Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants, having numerous pharmacological effects. UA and its analogs…”
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Protein aggregation and neurodegenerative diseases: From theory to therapy
Published in European journal of medicinal chemistry (29-11-2016)“…The study of protein misfolding and aggregation saw resurgence in the last decade. Aggregation is the main cause of several human neurodegenerative diseases…”
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Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies
Published in Molecules (Basel, Switzerland) (13-02-2020)“…Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that works under acute transcriptional control by several stimuli, including…”
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Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits
Published in Biomedicine & pharmacotherapy (01-07-2023)“…α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective,…”
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Identification and Evaluation of Inhibitors of Lipase from Malassezia restricta using Virtual High-Throughput Screening and Molecular Dynamics Studies
Published in International journal of molecular sciences (18-02-2019)“…Recent studies revealed the role of lipase in the pathogenicity of in dandruff and seborrheic dermatitis (D/SD). The lipase from (Mrlip1) is considered a…”
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Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition
Published in Scientific reports (25-06-2020)“…Microtubule affinity regulating kinase (MARK4) is a potential drug target for different types of cancer as it controls the early step of cell division. In this…”
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MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer's Disease Therapy
Published in Biomolecules (Basel, Switzerland) (20-05-2020)“…Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer's disease (AD) development as its overexpression is directly linked to increased…”
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