Search Results - "Hassan, Hanan M."

Editorial: Implication of oxidative, inflammatory, apoptotic and autophagy pathways in colitis by Hassan, Hanan M, Salama, Mohamed M

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Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway by Hassan, Hanan M., Alatawi, Nouf M., Bagalagel, Alaa, Diri, Reem, Noor, Ahmad, Almasri, Deina, Bakhsh, Hussain T., Kutbi, Hussam I., Ashy, Noha, Al-Gayyar, Mohammed M. H.

“…Gastric ulcer (GU) is a prevalent chronic digestive disease affecting about 10% of the world's population leading to gastrointestinal perforation and bleeding…”
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1,3,4-Oxadiazole N -Mannich Bases: Synthesis, Antimicrobial, and Anti-Proliferative Activities by Al-Wahaibi, Lamya H, Mohamed, Ahmed A B, Tawfik, Samar S, Hassan, Hanan M, El-Emam, Ali A

“…The reaction of 5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole-2(3 )-thione with formaldehyde solution and primary aromatic amines or 1-substituted piperazines, in…”
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X-ray Structures and Computational Studies of Two Bioactive 2-(Adamantane-1-carbonyl)- N -substituted Hydrazine-1-carbothioamides by Al-Wahaibi, Lamya H, Alagappan, Kowsalya, Blacque, Olivier, Mohamed, Ahmed A B, Hassan, Hanan M, Percino, María Judith, El-Emam, Ali A, Thamotharan, Subbiah

“…Two biologically active adamantane-linked hydrazine-1-carbothioamide derivatives, namely 2-(adamantane-1-carbonyl)- -( -butyl)hydrazine-1-carbothioamide) and…”
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Evaluating anticancer activity of emodin by enhancing antioxidant activities and affecting PKC/ADAMTS4 pathway in thioacetamide-induced hepatocellular carcinoma in rats by Hassan, Hanan M, Hamdan, Ahmed M, Alattar, Abdullah, Alshaman, Reem, Bahattab, Omar, Al-Gayyar, Mohammed M H

“…Emodin is a naturally occurring anthraquinone derivative with a wide range of pharmacological activities, including neuroprotective and anti-inflammatory…”
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Therapeutic effects of blocking β-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion by Hassan, Hanan M., El-Kannishy, Sherif M H, Alattar, Abdullah, Alshaman, Reem, Hamdan, Ahmed M, Al-Gayyar, Mohammed M H

“…[Display omitted] •iCRT14 is a β-catenin blocker.•iCRT14 significantly increased the survival of HCC rats.•iCRT14 treatment exhibited antitumor effects against…”
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Echinacoside ameliorates hepatic fibrosis and tumor invasion in rats with thioacetamide-induced hepatocellular carcinoma by Albalawi, Ajwan Z, Alatawi, Areej S, Al-Atwi, Shekha M, Alhwyty, Lama S, Alharbi, Kadi M, Alshehri, Shahad A, Almarwani, Wasayf A, Aljohani, Khulud K, Hassan, Hanan M, Al-Gayyar, Mohammed M H

“…Hepatocellular carcinoma (HCC) affects approximately 800,000 individuals globally each year. Despite advancements in HCC treatments, there is still a pressing…”
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Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives by Al-Abdullah, Ebtehal S, Al-Tuwaijri, Hanaa M, Hassan, Hanan M, Al-Alshaikh, Monirah A, Habib, Elsayed E, El-Emam, Ali A

“…The reaction of 1-adamantyl isothiocyanate 4 with the various cyclic secondary amines yielded the corresponding N-(1-adamantyl)carbothioamides 5a-e, 6, 7, 8a-c…”
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Supramolecular Self-Assembly Mediated by Multiple Hydrogen Bonds and the Importance of C–S···N Chalcogen Bonds in N′‑(Adamantan-2-ylidene)hydrazide Derivatives by Al-Wahaibi, Lamya H, Asokan, Karthick Vishal, Al-Shaalan, Nora H, Tawfik, Samar S, Hassan, Hanan M, El-Emam, Ali A, Percino, M. Judith, Thamotharan, Subbiah

“…The present article comprehensively examines six N′-(adamantan-2-ylidene)­hydrazide derivatives using the Hirshfeld surface analysis, PIXEL energy for…”
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Antimicrobial and hypoglycemic activities of novel N-Mannich bases derived from 5-(1-adamantyl)-4-substituted-1,2,4-triazoline-3-thiones by Al-Abdullah, Ebtehal S, Al-Tuwaijri, Hanaa M, Hassan, Hanan M, Haiba, Mogedda E, Habib, Elsayed E, El-Emam, Ali A

“…The reaction of 5-(1-adamantyl)-4-ethyl or allyl-1,2,4-triazoline-3-thione with formaldehyde solution and various 1-substituted piperazines yielded the…”
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Combined quercetin and simvastatin attenuate hepatic fibrosis in rats by modulating SphK1/NLRP3 pathways by Salama, Yasmin A, Hassan, Hanan M, El-Gayar, Amal M, Abdel-Rahman, Noha

“…Liver fibrosis involves several signalling pathways working in concert regulating the deposition of extracellular matrix. In this study, we evaluated the…”
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Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFβ-1 and TLR-4/NFκB signalling pathways by Hassan, Hanan M, Mahran, Yasmen F, Ghanim, Amal M H

“…Abstract Objectives Diabetic nephropathy (DN) is one of the most important complications of diabetes mellitus and it is considered as a principal cause for…”
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The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress by El-Baz, Ahmed M., Shata, Ahmed, Hassan, Hanan M., El-Sokkary, Mohamed M.A., Khodir, Ahmed E.

“…•The negative impact of T2DM on the liver and testicles is a major medical concern.•The change in abundance of the gut microbiota is directly correlated to…”
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Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis by Mahran, Yasmen F., Hassan, Hanan M.

“…Background. Cisplatin (cis-diaminedichloroplatinum, CDDP) is a broad-spectrum antineoplastic agent. However, CDDP has been blamed for its nephrotoxicity, which…”
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Unusual short intramolecular N–H⋅⋅⋅H–C contact and weak intermolecular interactions in two N-(adamantan-1-yl)piperazine carbothioamides: Crystallography, quantum chemical study and in vitro urease inhibitory activity by H． Al-Wahaibi, Lamya, Mangaiyarkarasi, Sivashanmugam, Blacque, Olivier, M． Hassan, Hanan, El-Emam, Ali． A．, Percino, M. Judith, Thamotharan, Subbiah

“…•X-ray crystal structures of two N-(adamantan-1-yl)piperazine carbothioamides were determined.•Conformational differences observed for piperazine…”
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A novel therapeutic combination of dapagliflozin, Lactobacillus and crocin attenuates diabetic cardiomyopathy in rats: Role of oxidative stress, gut microbiota, and PPARγ activation by Khalaf, Eman M., Hassan, Hanan M., El-Baz, Ahmed M., Shata, Ahmed, Khodir, Ahmed E., Yousef, Mahmoud E., Elgharabawy, Rehab Mohamed, Nouh, Nehal A., Saleh, Safaa, Bin-Meferij, Mashael M., El-kott, Attalla F., El-Sokkary, Mohamed M.A., Eissa, Hanan

“…Diabetic cardiomyopathy is diagnosed by the development of abnormality in the structure and performance of myocardium in diabetic mellitus (DM) patients…”
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Adamantane-Isothiourea Hybrid Derivatives: Synthesis, Characterization, In Vitro Antimicrobial, and In Vivo Hypoglycemic Activities by Al-Wahaibi, Lamya H, Hassan, Hanan M, Abo-Kamar, Amal M, Ghabbour, Hazem A, El-Emam, Ali A

“…A new series of adamantane-isothiourea hybrid derivatives, namely 4-arylmethyl ( )- '-(adamantan-1-yl)-morpholine-4-carbothioimidates - and 4-arylmethyl ( )-…”
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Synthesis, Antimicrobial, and Anti-Proliferative Activities of Novel 4-(Adamantan-1-yl)-1-arylidene-3-thiosemicarbazides, 4-Arylmethyl N '-(Adamantan-1-yl)piperidine-1-carbothioimidates, and Related Derivatives by Al-Mutairi, Aamal A, Al-Alshaikh, Monirah A, Al-Omary, Fatmah A M, Hassan, Hanan M, El-Mahdy, Areej M, El-Emam, Ali A

“…The reaction of 4-(adamantan-1-yl)-3-thiosemicarbazide with various aromatic aldehydes yielded the corresponding thiosemicarbazones . 1-Adamantyl…”
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Spectroscopic, Solvation Effects and MD Simulation of an Adamantane-Carbohydrazide Derivative, a Potential Antiviral Agent by Al-Wahaibi, Lamya H., Abdalla, Mohnad, Mary, Y. Sheena, Mary, Y. Shyma, Costa, Renyer Alves, Rana, Meenakshi, El-Emam, Ali A., Hassan, Hanan M., Al-Shaalan, Nora H.

“…The spectroscopic, solvent effects, reactivity and MD simulations of N'-[(1E)-(2,6-dichlorophenyl-methylidene]adamantane-1-carbohydrazide (DMC) are reported…”
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Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum : Theoretical and Experimental Study by Hassan, Hanan M, Al-Wahaibi, Lamya H, Elmorsy, Mohammed A, Mahran, Yasmen F

“…Drug-induced liver injury (DILI) is the most common cause of acute liver failure. The aim of this study was to investigate the molecular mechanisms by which…”
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