Search Results - "Hassan, Ghada S."

Role of the type 3 cytokines IL-17 and IL-22 in modulating metabolic dysfunction-associated steatotic liver disease by Abdelnabi, Mohamed N, Hassan, Ghada S, Shoukry, Naglaa H

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of liver diseases that span simple steatosis, metabolic…”
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The multifaceted role of macrophages during acute liver injury by Hassan, Ghada S., Flores Molina, Manuel, Shoukry, Naglaa H.

“…The liver is situated at the interface of the gut and circulation where it acts as a filter for blood-borne and gut-derived microbes and biological molecules,…”
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Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity by Al-Rashood, Sara T., Hamed, Ahmed R., Hassan, Ghada S., Alkahtani, Hamad M., Almehizia, Abdulrahman A., Alharbi, Amal, Al-Sanea, Mohammad M., Eldehna, Wagdy M.

“…In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive…”
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Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents by Eldehna, Wagdy M., Hassan, Ghada S., Al-Rashood, Sara T., Al-Warhi, Tarfah, Altyar, Ahmed E., Alkahtani, Hamad M., Almehizia, Abdulrahman A., Abdel-Aziz, Hatem A.

“…In connection with our research program on the development of novel anticancer candidates, herein we report the design and synthesis of novel series of…”
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CD154 inhibits death of T cells via a Cis interaction with the α5β1 integrin by Bachsais, Meriem, Salti, Suzanne, Zaoui, Kossay, Hassan, Ghada S., Aoudjit, Fawzi, Mourad, Walid

“…CD154 plays a major role in the pathogenesis of several autoimmune and inflammatory diseases. In addition to CD40, soluble CD154 (sCD154) binds to other…”
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Implications of CD154 and Its Receptors in the Pathogenesis and Treatment of Systemic Lupus Erythematosus by Allard, Catherine Cornet, Salti, Suzanne, Mourad, Walid, Hassan, Ghada S

“…CD154, also known as CD40 ligand, is a costimulatory molecule involved in humoral and adaptive immune responses upon pairing with its classical receptor, CD40…”
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Role of CD154 in cancer pathogenesis and immunotherapy by Hassan, Ghada S, Stagg, John, Mourad, Walid

“…Highlights • CD154 is a co-stimulatory molecule known for its role in inflammatory and autoimmune diseases. • CD154 and its receptor, CD40 are expressed in…”
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Interaction of CD154 with different receptors and its role in bidirectional signals by Alturaihi, Haydar, S. Hassan, Ghada, Al‐Zoobi, Loubna, Salti, Suzanne, Darif, Youssef, Yacoub, Daniel, Akoum, Souhad El, Oudghiri, Mounia, Merhi, Yahye, Mourad, Walid

“…In addition to its classical receptor, CD40, it is now well established that CD154 also binds αIIbβ3, α5β1, and αMβ2 integrins. Although these integrins are…”
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Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation by Eldehna, Wagdy M, Hassan, Ghada S, Al-Rashood, Sara T, Alkahtani, Hamad M, A Almehizia, Abdulrahman, Al-Ansary, Ghada H

“…Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel…”
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Distinct spatial distribution and roles of Kupffer cells and monocyte-derived macrophages in mouse acute liver injury by Flores Molina, Manuel, Abdelnabi, Mohamed N., Mazouz, Sabrina, Villafranca-Baughman, Deborah, Trinh, Vincent Quoc-Huy, Muhammad, Shafi, Bédard, Nathalie, Osorio Laverde, David, Hassan, Ghada S., Di Polo, Adriana, Shoukry, Naglaa H.

“…Macrophages are key regulators of inflammation and repair, but their heterogeneity and multiple roles in the liver are not fully understood. We aimed herein to…”
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Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis by Hassan, Ghada S, Salti, Suzanne, Mourad, Walid

“…CD154, an inflammatory mediator also known as CD40 ligand, has been identified as a novel binding partner for some members of the integrin family. The αIIbβ3,…”
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Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights by Abdelrahman, Mohamed A, Eldehna, Wagdy M, Nocentini, Alessio, Bua, Silvia, Al-Rashood, Sara T, Hassan, Ghada S, Bonardi, Alessandro, Almehizia, Abdulrahman A, Alkahtani, Hamad M, Alharbi, Amal, Gratteri, Paola, Supuran, Claudiu T

“…In this work, we present the synthesis and biological evaluation of novel series of diamide-based benzenesulfonamides 5a-h as inhibitors of the metalloenzyme…”
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The Interaction of CD154 with the α5β1 Integrin Inhibits Fas-Induced T Cell Death by Bachsais, Meriem, Naddaf, Nadim, Yacoub, Daniel, Salti, Suzanne, Alaaeddine, Nada, Aoudjit, Fawzi, Hassan, Ghada S, Mourad, Walid

“…CD154, a critical regulator of the immune response, is usually associated with chronic inflammatory, autoimmune diseases as well as malignant disorders. In…”
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Synthesis and Biological Evaluation of Thiazole-Based Derivatives as Potential Acetylcholinesterase Inhibitors by Hemaida, Aya Y, Hassan, Ghada S, Maarouf, Azza R, Joubert, Jacques, El-Emam, Ali A

“…Nineteen new thiazole-based derivatives were synthesized and their structures characterized with analytical and spectral data. The in vitro assessment of their…”
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Synthesis, antimicrobial, anti-biofilm evaluation, and molecular modelling study of new chalcone linked amines derivatives by El-Messery, Shahenda M., Habib, El-Sayed E., Al-Rashood, Sarah T. A., Hassan, Ghada S.

“…A series of amide chalcones conjugated with different secondary amines were synthesised and characterised by different spectroscopic techniques 1 H NMR, 13 C…”
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Requirement of transmembrane domain for CD154 association to lipid rafts and subsequent biological events by Benslimane, Nadir, Hassan, Ghada S, Yacoub, Daniel, Mourad, Walid

“…Interaction of CD40 with CD154 leads to recruitment of both molecules into lipid rafts, resulting in bi-directional cell activation. The precise mechanism by…”
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Enhancement of Rituximab-induced cell death by the physical association of CD20 with CD40 molecules on the cell surface by Al-Zoobi, Loubna, Salti, Suzanne, Colavecchio, Anna, Jundi, Malek, Nadiri, Amal, Hassan, Ghada S, El-Gabalawy, Hani, Mourad, Walid

“…CD20 is an attractive therapeutic target given the success of its monoclonal antibody, Rituximab, in the treatment of B-cell malignancies and B-cell-mediated…”
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Involvement of the cytoplasmic cysteine-238 of CD40 in its up-regulation of CD23 expression and its enhancement of TLR4-triggered responses by Nadiri, Amal, Jundi, Malek, El Akoum, Souhad, Hassan, Ghada S, Yacoub, Daniel, Mourad, Walid

“…CD40, a member of the tumor necrosis factor receptor superfamily, plays a key role in both adaptive and innate immunity. Engagement of CD40 with its natural…”
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Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC by Elmansi, Heba, Nasr, Jenny Jeehan, Rageh, Azza H., El-Awady, Mohamed I., Hassan, Ghada S., Abdel-Aziz, Hatem A., Belal, Fathalla

“…Background Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of…”
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Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction by Hassan, Ghada S, Williams, Terence M, Frank, Philippe G, Lisanti, Michael P

“…We previously showed that ablation of caveolin-1 (Cav-1) gene expression in mice promotes neointimal hyperplasia in vivo, a phenomenon normally characterized…”
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