Comprehensive insight into exploring the potential of microbial enzymes in cancer therapy: Progress, challenges, and opportunities: A review

Microbial enzymes are crucial catalysts in various industries due to their versatility and efficiency. The microbial enzymes market has recently expanded due to increased demand for many reasons. Among them are eco-friendly solutions, developing novel microbial strains with enhanced enzymes that per...

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Published in:	International journal of biological macromolecules Vol. 277; no. Pt 4; p. 134535
Main Authors:	Hassan, Fareed Shawky, El-Fakharany, Esmail M., El-Maradny, Yousra A., Saleh, Ahmed K., El-Sayed, Mohamed H., Mazi, Wafa, Omer, Noha, Abdelaziz, Mahmoud A., Jame, Rasha, Alatawi, Ibrahim Saleem, El-Gendi, Hamada
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-10-2024
Subjects:	Anticancer L-arginine deiminase L-asparaginase l-lysine α-oxidase L-methionine γ-lyase Microbial therapeutic-enzymes L-methionine γ-lyase Microbial therapeutic-enzymes L-arginine deiminase l-lysine α-oxidase Anticancer L-asparaginase
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Summary:	Microbial enzymes are crucial catalysts in various industries due to their versatility and efficiency. The microbial enzymes market has recently expanded due to increased demand for many reasons. Among them are eco-friendly solutions, developing novel microbial strains with enhanced enzymes that perform under harsh conditions, providing sustainability, and raising awareness about the benefits of enzyme-based products. By 2030, the global enzyme market is expected to account for $525 billion, with a growth rate of 6.7 %. L-asparaginase and L-glutaminase are among the leading applied microbial enzymes in antitumor therapy, with a growing market share of 16.5 % and 9.5 %, respectively. The use of microbial enzymes has opened new opportunities to fight various tumors, including leukemia, lymphosarcoma, and breast cancer, which has increased their demand in the pharmaceutical and medicine sectors. Despite their promising applications, commercial use of microbial enzymes faces challenges such as short half-life, immunogenicity, toxicity, and other side effects. Therefore, this review explores the industrial production, purification, formulation, and commercial utilization of microbial enzymes, along with an overview of the global enzyme market. With ongoing discoveries of novel enzymes and their applications, enzyme technology offers promising avenues for cancer treatment and other therapeutic interventions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0141-8130 1879-0003 1879-0003
DOI:	10.1016/j.ijbiomac.2024.134535