An MRI method for parcellating the human striatum into matrix and striosome compartments in vivo

An MRI method for parcellating the human striatum into matrix and striosome compartments in vivo

The mammalian striatum is comprised of intermingled tissue compartments, matrix and striosome. Though indistinguishable by routine histological techniques, matrix and striosome have distinct embryologic origins, afferent/efferent connections, surface protein expression, intra-striatal location, susc...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Vol. 246; p. 118714
Main Authors: Waugh, JL, Hassan, AAO, Kuster, JK, Levenstein, JM, Warfield, SK, Makris, N, Brüggemann, N, Sharma, N, Breiter, HC, Blood, AJ
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-02-2022
Elsevier Limited
Elsevier
Subjects:
Adolescent
Adult
Aged
Animals
Anisotropy
Brain research
Classification targets tractography
Corpus Striatum - anatomy & histology
Corpus Striatum - diagnostic imaging
Diffusion MRI
Diffusion Tensor Imaging - methods
Disease
Dystonia
Female
Humans
Magnetic resonance imaging
Male
Matrix
Middle Aged
Neostriatum
Neural networks
Patch
Segregation
Sensory neurons
Striatal compartments
Striosome
Young Adult
Diffusion MRI
Striatal compartments
Matrix
Patch
Classification targets tractography
Striosome
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Summary:The mammalian striatum is comprised of intermingled tissue compartments, matrix and striosome. Though indistinguishable by routine histological techniques, matrix and striosome have distinct embryologic origins, afferent/efferent connections, surface protein expression, intra-striatal location, susceptibilities to injury, and functional roles in a range of animal behaviors. Distinguishing the compartments previously required post-mortem tissue and/or genetic manipulation; we aimed to identify matrix/striosome non-invasively in living humans. We used diffusion MRI (probabilistic tractography) to identify human striatal voxels with connectivity biased towards matrix-favoring or striosome-favoring regions (determined by prior animal tract-tracing studies). Segmented striatal compartments replicated the topological segregation and somatotopic organization identified in animal matrix/striosome studies. Of brain regions mapped in prior studies, our human brain data confirmed 93% of the compartment-selective structural connectivity demonstrated in animals. Test-retest assessment on repeat scans found a voxel classification error rate of 0.14%. Fractional anisotropy was significantly higher in matrix-like voxels, while mean diffusivity did not differ between the compartments. As mapped by the Talairach human brain atlas, 460 regions were significantly biased towards either matrix or striosome. Our method allows the study of striatal compartments in human health and disease, in vivo, for the first time.
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These authors contributed equally to this work.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2021.118714