Search Results - "Hass, Daniel"

Uncoupling proteins in the mitochondrial defense against oxidative stress by Hass, Daniel T., Barnstable, Colin J.

“…Oxidative stress is a major component of most major retinal diseases. Many extrinsic anti-oxidative strategies have been insufficient at counteracting one of…”
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Mitochondrial Uncoupling Protein 2 Knock-out Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in a Mouse Model of Glaucoma by Hass, Daniel T, Barnstable, Colin J

“…Glaucoma is a neurodegenerative disorder characterized by mitochondrial dysfunction and an increase in oxidative damage, leading to retinal ganglion cell (RGC)…”
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Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium by Bisbach, Celia M., Hass, Daniel T., Robbings, Brian M., Rountree, Austin M., Sadilek, Martin, Sweet, Ian R., Hurley, James B.

“…When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic…”
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Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O 2 -Rich Pigment Epithelium by Bisbach, Celia M, Hass, Daniel T, Robbings, Brian M, Rountree, Austin M, Sadilek, Martin, Sweet, Ian R, Hurley, James B

“…When O is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic…”
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Medium Depth Influences O2 Availability and Metabolism in Human RPE Cultures by Hass, Daniel T, Zhang, Qitao, Autterson, Gillian A, Bryan, Richard A, Hurley, James B, Miller, Jason M L

“…Retinal pigment epithelium (RPE) oxidative metabolism is critical for normal retinal function and is often studied in cell culture systems. Here, we show that…”
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Poster Session II: Can a drug for liver disease be used to treat Age-Related Macular Degeneration? by Pandey, Kriti, Hass, Daniel T, Lim, Rayne R, Horton, Noah, Chao, Jennifer R, Hurley, James B

“…Age-related macular degeneration (AMD) is one of the most common degenerative eye diseases among the older population. One of the primary pathological features…”
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Cell Autonomous Neuroprotection by the Mitochondrial Uncoupling Protein 2 in a Mouse Model of Glaucoma by Hass, Daniel T, Barnstable, Colin J

“…Glaucoma is a group of disorders associated with retinal ganglion cell (RGC) degeneration and death. There is a clear contribution of mitochondrial dysfunction…”
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Succinate metabolism in the retinal pigment epithelium uncouples respiration from ATP synthesis by Hass, Daniel T, Bisbach, Celia M, Robbings, Brian M, Sadilek, Martin, Sweet, Ian R, Hurley, James B

“…Fumarate can be a surrogate for O as a terminal electron acceptor in the electron transport chain. Reduction of fumarate produces succinate, which can be…”
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Monocarboxylate Transporter 1 (MCT1) Mediates Succinate Export in the Retina by Bisbach, Celia M, Hass, Daniel T, Thomas, Eric D, Cherry, Timothy J, Hurley, James B

“…Succinate is exported by the retina and imported by eyecup tissue. The transporters mediating this process have not yet been identified. Recent studies showed…”
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Aerobic Glycolysis in Photoreceptors Supports Energy Demand in the Absence of Mitochondrial Coupling by Hass, Daniel T, Bisbach, Celia M, Sadilek, Martin, Sweet, Ian R, Hurley, James B

“…Metabolism is adapted to meet energetic needs. Based on the amount of ATP required to maintain plasma membrane potential, photoreceptor energy demands must be…”
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Acetyl-CoA carboxylase inhibition increases retinal pigment epithelial cell fatty acid flux and restricts apolipoprotein efflux by Hass, Daniel T., Pandey, Kriti, Engel, Abbi, Horton, Noah, Haydinger, Cameron D., Robbings, Brian M., Lim, Rayne R., Sadilek, Martin, Zhang, Qitao, Gulette, Gillian A., Li, Amy, Xu, Libin, Miller, Jason M.L., Chao, Jennifer R., Hurley, James B.

“…Lipid-rich deposits called drusen accumulate under the retinal pigment epithelium (RPE) in the eyes of patients with age-related macular degeneration and…”
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Reassessing retinal pigment epithelial ketogenesis: Enzymatic assays for ketone body levels provide inaccurate results by Gulette, Gillian A., Hass, Daniel T., Pandey, Kriti, Zhang, Qitao, Han, John Y.S., Engel, Abbi, Chao, Jennifer R., Philp, Nancy J., Hurley, James B., Miller, Jason M.L.

“…The retinal pigment epithelium (RPE) is omnivorous and can utilize a wide range of substrates for oxidative phosphorylation. Certain tissues with high…”
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Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers by Berkowitz, Bruce A, Podolsky, Robert H, Childers, Karen Lins, Roberts, Robin, Katz, Ryan, Waseem, Rida, Robbings, Brian M, Hass, Daniel T, Hurley, James B, Sweet, Ian R, Goodman, Cole, Qian, Haohua, Alvisio, Bruno, Heaps, Sam

“…To test the hypothesis that rod energy biomarkers in light and dark are similar in mice without functional rod transducin (Gnat1rd17). Gnat1rd17 and wildtype…”
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Uncoupling protein 2 in the glial response to stress：implications for neuroprotection by Hass, Daniel, Barnstable, Colin

“…Reactive oxygen species（ROS） are free radicals thought to mediate the neurotoxic effects of several neurodegenerative disorders.In the central nervous…”
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An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice by Tsantilas, Kristine A, Cleghorn, Whitney M, Bisbach, Celia M, Whitson, Jeremy A, Hass, Daniel T, Robbings, Brian M, Sadilek, Martin, Linton, Jonathan D, Rountree, Austin M, Valencia, Ana P, Sweetwyne, Mariya T, Campbell, Matthew D, Zhang, Huiliang, Jankowski, Connor S R, Sweet, Ian R, Marcinek, David J, Rabinovitch, Peter S, Hurley, James B

“…The purpose of this study was to present our hypothesis that aging alters metabolic function in ocular tissues. We tested the hypothesis by measuring…”
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Maintaining and Assessing Various Tissue and Cell Types of the Eye Using a Novel Pumpless Fluidics System by Grumbine, Matthew K, Kamat, Varun, Bao, Khang, Crupi, Trevor, Mokate, Kedar, Lim, Rayne, Chao, Jennifer R, Robbings, Brian M, Hass, Daniel T, Hurley, James B, Sweet, Ian R

“…Many in vitro models used to investigate tissue function and cell biology require a flow of media to provide adequate oxygenation and optimal cell conditions…”
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CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa by Nolan, Nicholas D., Cui, Xuan, Robbings, Brian M., Demirkol, Aykut, Pandey, Kriti, Wu, Wen-Hsuan, Hu, Hannah F., Jenny, Laura A., Lin, Chyuan-Sheng, Hass, Daniel T., Du, Jianhai, Hurley, James B., Tsang, Stephen H.

“…Retinitis pigmentosa (RP) is one of the most common forms of hereditary neurodegeneration. It is caused by one or more of at least 3,100 mutations in over 80…”
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A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells by Kamat, Varun, Grumbine, Matthew K, Bao, Khang, Mokate, Kedar, Khalil, Gamal, Cook, Daniel, Clearwater, Brandon, Hirst, Richard, Harman, Jarrod, Boeck, Myriam, Fu, Zhongjie, Smith, Lois E H, Goswami, Moloy, Wubben, Thomas J, Walker, Emily M, Zhu, Jie, Soleimanpour, Scott A, Scarlett, Jarrad M, Robbings, Brian M, Hass, Daniel, Hurley, James B, Sweet, Ian R

“…To address the needs of the life sciences community and the pharmaceutical industry in pre-clinical drug development to both maintain and continuously assess…”
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The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development by Xing, Tiaosi, Hass, Daniel T, Zhang, Samuel S, Barnstable, Colin J

“…The transition of rod precursor cells to post-mitotic rod photoreceptors can be promoted by extrinsic factors such as insulin-like growth factor 1 (IGF-1),…”
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Mitochondrial Uncoupling Protein 2 Knockout Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in a Mouse Model of Glaucoma by Hass, Daniel T, Barnstable, Colin J

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