Search Results - "Hasler, J A"

Pharmacogenetics in Africa, an Opportunity for Appropriate Drug Dosage Regimens: on the Road to Personalized Healthcare by Masimirembwa, C, Hasler, JA

“…The modern human appeared in Africa around 200,000 years ago with subsequent later migrations to populate Europe, Asia, and North America.1 As humans adapted…”
Get full text

Effects of DIMBOA on detoxification enzymes of the aphid Rhopalosiphum padi (Homoptera: aphididae) by Mukanganyama, S, Figueroa, C.C, Hasler, J.A, Niemeyer, H.M

“…The presence of glutathione transferases and esterase activity was investigated in Rhopalosiphum padi and the effects of the cereal hydroxamic acid,…”
Get full text

Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe by Todd, C H, Allain, T, Gomo, Z A, Hasler, J A, Ndiweni, M, Oken, E

Get more information

Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe by Masimirembwa, C, Bertilsson, L, Johansson, I, Hasler, J A, Ingelman-Sundberg, M

“…The S-mephenytoin hydroxylase has recently been identified as cytochrome P450 2C19 (CYP2C19). This enzyme metabolizes mephenytoin, diazepam, omeprazole, and…”
Get more information

Pharmacogenetics of cytochromes P450 by Hasler, J A

Get full text

Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6 by MASIMIREMBWA, C. M, HASLER, J. A, JOHANSSON, I

“…The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three…”
Get full text

Characterisation of praziquantel metabolism by rat liver microsomes using cytochrome P450 inhibitors by Masimirembwa, C M, Hasler, J A

“…The metabolism of praziquantel (PZQ) was studied in microsomes isolated from livers of differently pretreated rats and in the presence of various inhibitors of…”
Get more information

Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity by Hasler, J A, Harlow, G R, Szklarz, G D, John, G H, Kedzie, K M, Burnett, V L, He, Y A, Kaminsky, L S, Halpert, J R

“…Eleven amino acid residues unique to dog cytochrome P450 (P450) 2B11, compared with rat 2B1 and 2B2, rabbit 2B4 and 2B5, and mouse 2B10, in the putative…”
Get more information

Molecular dosimetry in rat urine of aflatoxin-N7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and immunoaffinity/high performance liquid chromatography by GROOPMAN, J. D, HASLER, J. A, TRUDEL, L. J, PIKUL, A, DONAHUE, P. R, WOGAN, G. N

“…The development of molecular dosimetry methods will simplify the identification of people at high risk for cancer. A combined monoclonal antibody…”
Get full text

The effect of chloroquine on the pharmacokinetics and metabolism of praziquantel in rats and in humans by Masimirembwa, C M, Naik, Y S, Hasler, J A

“…It is likely that a proportion of people treated with the anti-schistosomicidal drug praziquantel (PZQ) is also taking other drugs such as chloroquine (CHQ), a…”
Get more information

Application of Higher Throughput Screening (HTS) Inhibition Assays to Evaluate the Interaction of Antiparasitic Drugs with Cytochrome P450s by BAPIRO, Tashinga E, EGNELL, Ann-Charlotte, HASLER, Julia A, MASIMIREMBWA, Collen M

“…In this study we have evaluated the application and reliability of using fluorescence (FLUO)-based high throughput screening assays with recombinant CYPs…”
Get full text

Low CYP1A2 activity in rural Shona children of Zimbabwe by Masimirembwa, C M, Beke, M, Hasler, J A, Tang, B K, Kalow, W

“…Caffeine is increasingly used as a biochemical probe for liver function, in cancer epidemiology, and in pharmacogenetics, with its recognized ability to assess…”
Get more information

Effects of phenobarbital and 3-methylcholanthrene pretreatment of the pharmacokinetics of praziquantel in rats by MASIMIREMBWA, C. M, NAIK, Y. S, HASLER, J. A

“…The effects of phenobarbital (PB) and 3-methylcholanthrene (MC) pretreatment on the pharmacokinetics of praziquantel (PZQ), a schistosomicide were studied in…”
Get full text

The effect of experimental Schistosoma mattheei infection on hepatic drug metabolism in BALB/c mice by Naik, Y S, Hasler, J A

Get more information

Genetic Polymorphism of Drug Metabolising Enzymes in African Populations: Implications for the Use of Neuroleptics and Antidepressants by Masimirembwa, Collen M., Hasler, Julia A.

“…Metabolism of most drugs influences their pharmacological and toxicological effects. Drugs particularly affected are those with a narrow therapeutic window and…”
Get full text

Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney by Magwere, Tapiwanashe, Naik, Yogeshkumar S, Hasler, Julia A

“…The effect of chloroquine (CHQ) administration on antioxidant enzymes in rat liver and kidney was studied. Male Sprague–Dawley rats were administered 20 mg/kg…”
Get full text

Genetic polymorphism of CYP2D6 and CYP2C19 in East- and Southern African populations including psychiatric patients by DANDARA, Collet, COLLEN MUTOWEMBWA MASIMIREMBWA, MAGIMBA, Ayoub, SAYI, Jane, KAAYA, Sylvia, SOMMERS, De K, SNYMAN, J. R, HASLER, Julia Anne

“…The study was carried out to investigate the distribution of cytochrome P450 2D6 (CYP2D6) and CYP2C19 genotype frequencies in three African populations and to…”
Get full text

Human exposure to aflatoxins in Zimbabwe by Nyathi, C B, Mutiro, C F, Hasler, J A, Chetsanga, C J

“…In this communication, we report the detection of aflatoxins in human urine and breast milk. The 2553 urine samples were collected from donors of different…”
Get more information

A survey of urinary aflatoxin in Zimbabwe by Nyathi, C B, Mutiro, C F, Hasler, J A, Chetsanga, C J

“…In this study, 1228 urine samples were collected from different centres in Zimbabwe and were analysed for aflatoxin contamination. The urine samples were…”
Get more information

Proposed reductive metabolism of artemisinin by glutathione transferases in vitro by Mukanganyama, S, Naik, Y S, Widersten, M, Mannervik, B, Hasler, J A

“…Artemisinin is a sesquiterpene lactone containing an endoperoxide bridge. It is a promising new antimalarial and is particularly useful against the drug…”
Get more information