Search Results - "Hasler, A"

Visual-palpatory versus fluoroscopic intraoperative determination of the femoral entry point in medial patellofemoral ligament reconstruction by Herschel, R., Hasler, A., Tscholl, P. M., Fucentese, S. F.

“…Purpose Malpositioning of the femoral entry point in reconstruction of the medial patellofemoral ligament (MPFL) can lead to abnormal and painful patellar…”
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Temperature variability and offset in steep alpine rock and ice faces by Hasler, A, Gruber, S, Haeberli, W

“…The thermal condition of high-alpine mountain flanks can be an important determinant of climate change impact on slope stability and correspondingly down-slope…”
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The influence of surface characteristics, topography and continentality on mountain permafrost in British Columbia by Hasler, A, Geertsema, M, Foord, V, Gruber, S, Noetzli, J

“…Thermal and surface offsets describe mean annual ground temperature relative to mean annual air temperature, and for permafrost modelling they are often…”
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SLC38A9 regulates SARS-CoV-2 viral entry by Datta, Gaurav, Rezagholizadeh, Neda, Hasler, Wendie A., Khan, Nabab, Chen, Xuesong

“…SARS-CoV-2 viral entry into host cells depends on the cleavage of spike (S) protein into S1 and S2 proteins. Such proteolytic cleavage by furin results in the…”
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Application of Higher Throughput Screening (HTS) Inhibition Assays to Evaluate the Interaction of Antiparasitic Drugs with Cytochrome P450s by BAPIRO, Tashinga E, EGNELL, Ann-Charlotte, HASLER, Julia A, MASIMIREMBWA, Collen M

“…In this study we have evaluated the application and reliability of using fluorescence (FLUO)-based high throughput screening assays with recombinant CYPs…”
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Pharmacogenetics in Africa, an Opportunity for Appropriate Drug Dosage Regimens: on the Road to Personalized Healthcare by Masimirembwa, C, Hasler, JA

“…The modern human appeared in Africa around 200,000 years ago with subsequent later migrations to populate Europe, Asia, and North America.1 As humans adapted…”
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Tracking nonrigid motion and structure from 2D satellite cloud images without correspondences by Lin Zhou, Kambhamettu, C., Goldgof, D.B., Palaniappan, K., Hasler, A.F.

“…Tracking both structure and motion of nonrigid objects from monocular images is an important problem in vision. In this paper, a hierarchical method which…”
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Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe by Masimirembwa, C, Bertilsson, L, Johansson, I, Hasler, J A, Ingelman-Sundberg, M

“…The S-mephenytoin hydroxylase has recently been identified as cytochrome P450 2C19 (CYP2C19). This enzyme metabolizes mephenytoin, diazepam, omeprazole, and…”
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Inhibition of glutathione S‐transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance by Mukanganyama, Stanley, Widersten, Mikael, Naik, Yogeshkumar S., Mannervik, Bengt, Hasler, Julia A.

“…A strategy to overcome multidrug resistance in cancer cells involves treatment with a combination of the antineoplastic agent and a chemomodulator that…”
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Human cytochromes P450 by Hasler, Julia A, Estabrook, Ronald, Murray, Michael, Pikuleva, Irina, Waterman, Michael, Capdevila, Jorge, Holla, Vijakumar, Helvig, Christian, Falck, John R, Farrell, Geoffrey, Kaminsky, Laurence S, Spivack, Simon D, Boitier, Eric, Beaune, Philippe

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Effects of Chloroquine Treatment on Antioxidant Enzymes in Rat Liver and Kidney by Magwere, Tapiwanashe, Naik, Yogeshkumar S, Hasler, Julia A

“…The effect of chloroquine (CHQ) administration on antioxidant enzymes in rat liver and kidney was studied. Male Sprague–Dawley rats were administered 20 mg/kg…”
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Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans by BAPIRO, Tashinga E, SAYI, Jane, HASLER, Julia A, JANDE, Mary, RIMOY, Gerald, MASSELLE, Amos, MASIMIREMBWA, Collen M

“…To investigate the likelihood of artemisinin and thiabendazole causing pharmacokinetic interactions involving cytochrome P450 (CYP1A2) in humans given their…”
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High-Resolution Wind Fields within the Inner Core and Eye of a Mature Tropical Cyclone from GOES 1-min Images by Hasler, A. F., Palaniappan, K., Kambhammetu, C., Black, P., Uhlhorn, E., Chesters, D.

“…Mesoscale wind fields have been determined for a mature hurricane with high spatial and temporal resolution, continuity, and coherency. These wind fields, near…”
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Effects of DIMBOA on detoxification enzymes of the aphid Rhopalosiphum padi (Homoptera: aphididae) by Mukanganyama, S, Figueroa, C.C, Hasler, J.A, Niemeyer, H.M

“…The presence of glutathione transferases and esterase activity was investigated in Rhopalosiphum padi and the effects of the cereal hydroxamic acid,…”
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The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6.17 (CYP2D6.17) variant: Potential implications for CYP2D6 phenotyping studies and the clinical use of CYP2D6 substrate drugs in some African populations by Bapiro, Tashinga E, Hasler, Julia A, Ridderström, Marianne, Masimirembwa, Collen M

“…In this study, the basis for the diminished capacity of CYP2D6.17 to metabolise CYP2D6 substrate drugs and the possible implications this might have for CYP2D6…”
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Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe by Todd, C H, Allain, T, Gomo, Z A, Hasler, J A, Ndiweni, M, Oken, E

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Genetic polymorphism of cytochrome P450 1A1 (Cyp1A1) and glutathione transferases (M1, T1 and P1) among Africans by Dandara, Collet, Sayi, Jane, Masimirembwa, Collen M, Magimba, Ayoub, Kaaya, Sylvia, De Sommers, Kierk, Snyman, Jacques René, Hasler, Julia A

“…The co-ordinate expression and regulation of the drug metabolising enzymes, cytochrome P4501A1 (CYPlAl) and glutathione transferases (GSTM1, GSTT1 and GSTP1),…”
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Genetic Polymorphism of Drug Metabolising Enzymes in African Populations: Implications for the Use of Neuroleptics and Antidepressants by Masimirembwa, Collen M., Hasler, Julia A.

“…Metabolism of most drugs influences their pharmacological and toxicological effects. Drugs particularly affected are those with a narrow therapeutic window and…”
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Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells by BAPIRO, Tashinga E, ANDERSSON, Tommy B, OTTER, Charlotta, HASLER, Julia A, MASIMIREMBWA, Collen M

“…To investigate the inductive effects of twenty-four antiparasitic drugs on cytochrome P450 (CYP) 1A1 and 1A2 enzyme activities. Human hepatoma (HepG2) cells…”
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Frequency of -163 C>A and 63 C>G single nucleotide polymorphism of cytochrome P450 1A2 in two African populations by Dandara, Collet, Basvi, Patience T, Bapiro, Tashinga E, Sayi, Jane, Hasler, Julia A

“…Cytochrome P450 1A2 (CYP1A2) is an important member of the cytochrome P450 superfamily of enzymes because of its involvement in the metabolism of some…”
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