Search Results - "Haslbeck, Martin"

Small heat shock proteins: Simplicity meets complexity by Haslbeck, Martin, Weinkauf, Sevil, Buchner, Johannes

“…Small heat shock proteins (sHsps) are a ubiquitous and ancient family of ATP-independent molecular chaperones. A key characteristic of sHsps is that they exist…”
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The Heat Shock Response: Life on the Verge of Death by Richter, Klaus, Haslbeck, Martin, Buchner, Johannes

“…Organisms must survive a variety of stressful conditions, including sudden temperature increases that damage important cellular structures and interfere with…”
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Independent evolution of the core domain and its flanking sequences in small heat shock proteins by Kriehuber, Thomas, Rattei, Thomas, Weinmaier, Thomas, Bepperling, Alexander, Haslbeck, Martin, Buchner, Johannes

“…Small heat shock proteins (sHsps) are molecular chaperones involved in maintaining protein homeostasis; they have also been implicated in protein folding…”
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Regulation of small heat-shock proteins by hetero-oligomer formation by Mymrikov, Evgeny V., Riedl, Mareike, Peters, Carsten, Weinkauf, Sevil, Haslbeck, Martin, Buchner, Johannes

“…Small heat-shock proteins (sHsps) compose the most widespread family of molecular chaperones. The human genome encodes 10 different sHsps (HspB1–10). It has…”
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The Heat Shock Response in Yeast Maintains Protein Homeostasis by Chaperoning and Replenishing Proteins by Mühlhofer, Moritz, Berchtold, Evi, Stratil, Chris G., Csaba, Gergely, Kunold, Elena, Bach, Nina C., Sieber, Stephan A., Haslbeck, Martin, Zimmer, Ralf, Buchner, Johannes

“…Life is resilient because living systems are able to respond to elevated temperatures with an ancient gene expression program called the heat shock response…”
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Alternative Splicing in Next Generation Sequencing Data of Saccharomyces cerevisiae by Schreiber, Konrad, Csaba, Gergely, Haslbeck, Martin, Zimmer, Ralf

“…mRNA splicing is required in about 4% of protein coding genes in Saccharomyces cerevisiae. The gene structure of those genes is simple, generally comprising…”
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Alternative bacterial two-component small heat shock protein systems by Bepperling, Alexander, Alte, Ferdinand, Kriehuber, Thomas, Braun, Nathalie, Weinkauf, Sevil, Groll, Michael, Haslbeck, Martin, Buchner, Johannes

“…Small heat shock proteins (sHsps) are molecular chaperones that prevent the aggregation of nonnative proteins. The sHsps investigated to date mostly form…”
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The growing world of small heat shock proteins: from structure to functions by Carra, Serena, Alberti, Simon, Arrigo, Patrick A., Benesch, Justin L., Benjamin, Ivor J., Boelens, Wilbert, Bartelt-Kirbach, Britta, Brundel, Bianca J. J. M., Buchner, Johannes, Bukau, Bernd, Carver, John A., Ecroyd, Heath, Emanuelsson, Cecilia, Finet, Stephanie, Golenhofen, Nikola, Goloubinoff, Pierre, Gusev, Nikolai, Haslbeck, Martin, Hightower, Lawrence E., Kampinga, Harm H., Klevit, Rachel E., Liberek, Krzysztof, Mchaourab, Hassane S., McMenimen, Kathryn A., Poletti, Angelo, Quinlan, Roy, Strelkov, Sergei V., Toth, Melinda E., Vierling, Elizabeth, Tanguay, Robert M.

“…Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular…”
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Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly by Taş, Karin, Volta, Beatrice Dalla, Lindner, Christina, El Bounkari, Omar, Hille, Kathleen, Tian, Yuan, Puig-Bosch, Xènia, Ballmann, Markus, Hornung, Simon, Ortner, Martin, Prem, Sophia, Meier, Laura, Rammes, Gerhard, Haslbeck, Martin, Weber, Christian, Megens, Remco T. A., Bernhagen, Jürgen, Kapurniotu, Aphrodite

“…Amyloid self-assembly is linked to numerous devastating cell-degenerative diseases. However, designing inhibitors of this pathogenic process remains a major…”
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Phosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble by Mühlhofer, Moritz, Peters, Carsten, Kriehuber, Thomas, Kreuzeder, Marina, Kazman, Pamina, Rodina, Natalia, Reif, Bernd, Haslbeck, Martin, Weinkauf, Sevil, Buchner, Johannes

“…Hsp26 is a small heat shock protein (sHsp) from S. cerevisiae . Its chaperone activity is activated by oligomer dissociation at heat shock temperatures. Hsp26…”
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Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach by Braun, Nathalie, Zacharias, Martin, Peschek, Jirka, Kastenmüller, Andreas, Zou, Juan, Hanzlik, Marianne, Haslbeck, Martin, Rappsilber, Juri, Buchner, Johannes, Weinkauf, Sevil

“…The molecular chaperone αB-crystallin, the major player in maintaining the transparency of the eye lens, prevents stress-damaged and aging lens proteins from…”
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Proteinaceous Transformers: Structural and Functional Variability of Human sHsps by Riedl, Mareike, Strauch, Annika, Catici, Dragana A M, Haslbeck, Martin

“…The proteostasis network allows organisms to support and regulate the life cycle of proteins. Especially regarding stress, molecular chaperones represent the…”
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eye lens chaperone α-crystallin forms defined globular assemblies by Peschek, Jirka, Braun, Nathalie, Franzmann, Titus M, Georgalis, Yannis, Haslbeck, Martin, Weinkauf, Sevil, Buchner, Johannes

“…α-Crystallins are molecular chaperones that protect vertebrate eye lens proteins from detrimental protein aggregation. αB-Crystallin, 1 of the 2 α-crystallin…”
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Comparative Analysis of Benzoxazinoid Biosynthesis in Monocots and Dicots: Independent Recruitment of Stabilization and Activation Functions by Dick, Regina, Rattei, Thomas, Haslbeck, Martin, Schwab, Wilfried, Gierl, Alfons, Frey, Monika

“…Benzoxazinoids represent preformed protective and allelophatic compounds that are found in a multitude of species of the family Poaceae (Gramineae) and occur…”
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The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes by Fleckenstein, Tilly, Kastenmüller, Andreas, Stein, Martin Lorenz, Peters, Carsten, Daake, Marina, Krause, Maike, Weinfurtner, Daniel, Haslbeck, Martin, Weinkauf, Sevil, Groll, Michael, Buchner, Johannes

“…Small heat shock proteins (sHsps) are ubiquitous molecular chaperones that prevent the aggregation of unfolding proteins during proteotoxic stress. In…”
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The molecular basis of chaperone-mediated interleukin 23 assembly control by Meier, Susanne, Bohnacker, Sina, Klose, Carolin J., Lopez, Abraham, Choe, Christian A., Schmid, Philipp W. N., Bloemeke, Nicolas, Rührnößl, Florian, Haslbeck, Martin, Bieren, Julia Esser-von, Sattler, Michael, Huang, Po-Ssu, Feige, Matthias J.

“…The functionality of most secreted proteins depends on their assembly into a defined quaternary structure. Despite this, it remains unclear how cells…”
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Magnetic One-Step Purification of His-Tagged Protein by Bare Iron Oxide Nanoparticles by Schwaminger, Sebastian P, Fraga-García, Paula, Blank-Shim, Silvia A, Straub, Tamara, Haslbeck, Martin, Muraca, Francesco, Dawson, Kenneth A, Berensmeier, Sonja

“…Magnetic separation is a promising alternative to conventional methods in downstream processing. This can facilitate easier handling, fewer processing steps,…”
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A First Line of Stress Defense: Small Heat Shock Proteins and Their Function in Protein Homeostasis by Haslbeck, Martin, Vierling, Elizabeth

“…Small heat shock proteins (sHsps) are virtually ubiquitous molecular chaperones that can prevent the irreversible aggregation of denaturing proteins. sHsps…”
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Identification and Characterization of a Stress-Inducible and a Constitutive Small Heat-Shock Protein Targeted to the Matrix of Plant Peroxisomes by Ma, Changle, Haslbeck, Martin, Babujee, Lavanya, Jahn, Olaf, Reumann, Sigrun

“…Small heat-shock proteins (sHsps) are widespread molecular chaperones for which a peroxisomal localization has not yet been reported. The Arabidopsis…”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Diesinger, Torsten, Lautwein, Alfred, Bergler, Sebastian, Buckert, Dominik, Renz, Christian, Dvorsky, Radovan, Buko, Vyacheslav, Kirko, Siarhei, Schneider, Edith, Kuchenbauer, Florian, Kumar, Mukesh, Günes, Cagatay, Genze, Felicitas, Büchele, Berthold, Simmet, Thomas, Haslbeck, Martin, Masur, Kai, Barth, Thomas, Müller-Enoch, Dieter, Wirth, Thomas, Haehner, Thomas

“…Cytochrome P450 2E1 (CYP2E1) is a key target protein in the development of alcoholic and nonalcoholic fatty liver disease (FLD). The pathophysiological…”
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