Search Results - "Hasinoff, B.B."

Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines by Hasinoff, B B, Hellmann, K, Herman, E H, Ferrans, V J

“…The bisdioxopiperazine dexrazoxane (ICRF-187) has proven to be clinically very effective in reducing the cardiotoxicity of doxorubicin and other…”
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Production of Hydroxyl Radical by Iron(III)-Anthraquinone Complexes through Self-Reduction and through Reductive Activation by the Xanthine Oxidase/Hypoxanthine System by Malisza, K.L., Hasinoff, B.B.

“…The iron(III) complexes of doxorubicin and epirubicin were observed to undergo a self-reduction (autoxidation) reaction in the absence of added reductants…”
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Class-1 hemoglobins, nitrate and NO levels in anoxic maize cell-suspension cultures by Dordas, C, Hasinoff, B.B, Rivoal, J, Hill, R.D

“…Nitric oxide (NO) is a reactive gas involved in many biological processes of animals, plants and microbes. Previous work has demonstrated that NO is formed…”
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Regulation Of B16F1 melanoma cell metastasis by inducible functions of the hepatic microvasculature by Wang, H.H., McIntosh, A.R., Hasinoff, B.B., MacNeil, B., Rector, E., Nance, D.M., Orr, F.W.

“…We have previously shown that circulating intravascular cells generally arrest by mechanical restriction in the hepatic sinusoids, causing rapid release of…”
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Doxorubicin Reduces the Iron(III) Complexes of the Hydrolysis Products of the Antioxidant Cardioprotective Agent Dexrazoxane (ICRF-187) and Produces Hydroxyl Radicals by Malisza, K.L., Hasinoff, B.B.

“…Dexrazoxane (ICRF-187) is very effective in protecting against doxorubicin-induced cardiotoxicity. Dexrazoxane likely acts though its metal ion binding…”
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Ferrous Ion Strongly Promotes the Ring Opening of the Hydrolysis Intermediates of the Antioxidant Cardioprotective Agent Dexrazoxane (ICRF-187) by Buss, J.L., Hasinoff, B.B.

“…The ferrous- and ferric-ion-promoted hydrolysis of the doxorubicin cardioprotective agent dexrazoxane (ICRF-187) has been studied spectrophotometrically and by…”
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NADPH-cytochrome-P-450 reductase promoted hydroxyl radical production by the iron(III)-ochratoxin A complex by Hasinoff, B B, Rahimtula, A D, Omar, R F

“…The Fe3+ complex of ochratoxin A has been shown to produce hydroxyl radicals in the presence of NADPH and NADPH-cytochrome-P-450 reductase. ESR spin-trapping…”
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