Search Results - "Hashimoto, Terumasa"

Effect of SMTP-7 on Cisplatin-Induced Nephrotoxicity in Mice by Hashimoto, Terumasa, Shibata, Keita, Hasumi, Keiji, Honda, Kazuo, Nobe, Koji

“…SMTP-7, a fungal metabolite, is reported to have a high degree of availability for the ischemia–reperfusion (IR)-induced acute kidney injury (AKI) model…”
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Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small molecule having anti-inflammatory and antioxidant activities, in a mouse model of acute kidney injury by Shibata, Keita, Hashimoto, Terumasa, Hasumi, Keiji, Nobe, Koji

“…Acute kidney injury (AKI) increases the risk of chronic kidney disease (CKD), complicates existing CKD, and can lead to the end-stage renal disease. However,…”
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Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future by Shibata, Keita, Hashimoto, Terumasa, Miyazaki, Takuro, Miyazaki, Akira, Nobe, Koji

“…Thromboembolic ischemic stroke, which is mainly caused by hypertension, as well as plasma dyslipidemia, arterial fibrillation and diabetes, is a leading cause…”
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Acetic acid treatment causes renal inflammation and chronic kidney disease in mice by Hashimoto, Terumasa, Shibata, Keita, Honda, Kazuo, Nobe, Koji

“…We established a novel mouse model of chronic kidney disease (CKD) using acetic acid and compared it with the 5/6-nephrectomized mouse model. In our novel…”
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Evaluation of the effects of a new series of SMTPs in the acetic acid-induced embolic cerebral infarct mouse model by Shibata, Keita, Hashimoto, Terumasa, Hasumi, Keiji, Honda, Kazuo, Nobe, Koji

“…We reported previously that Stachybotrys microspora triprenyl phenol-7 (SMTP-7) showed potential thrombolytic, anti-inflammatory and anti-oxidant effects that…”
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Altered Gene Expression in an Embolic Stroke Model After Thrombolysis With Tissue Plasminogen Activator and Stachybotrys microspora Triprenyl Phenol-7 by Hashimoto, Terumasa, Shibata, Keita, Ohata, Hisayuki, Hasumi, Keiji, Honda, Kazuo

“…The present study compares gene expression and infarct area in a mouse model of embolic stroke after thrombolysis with t-PA and SMTP-7. Embolic occlusion was…”
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Distinct Effects of Tissue-Type Plasminogen Activator and SMTP-7 on Cerebrovascular Inflammation Following Thrombolytic Reperfusion by MIYAZAKI, Takuro, KIMURA, Yuji, OHATA, Hisayuki, HASHIMOTO, Terumasa, SHIBATA, Keita, HASUMI, Keiji, HONDA, Kazuo

“…Thrombolysis therapy using tissue-type plasminogen activator (t-PA) is occasionally accompanied by harmful outcomes, including intracerebral hemorrhage. We…”
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Two types of overcontraction are involved in intrarenal artery dysfunction in type II diabetic mouse by Nobe, Koji, Takenouchi, Yasuhiro, Kasono, Keizo, Hashimoto, Terumasa, Honda, Kazuo

“…Contractile responses in small intrarenal arteries are associated with diabetic nephropathy. However, the mechanisms that induce and maintain altered small…”
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SMTP‐44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti‐inflammatory activities by Shinouchi, Ryosuke, Shibata, Keita, Hashimoto, Terumasa, Jono, Shiori, Hasumi, Keiji, Nobe, Koji

“…Diabetic neuropathy (DN) is one of the major complications of diabetes. However, there are few approved effective therapies for painful or insensate DN. Recent…”
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A Novel Embolic Model of Cerebral Infarction and Evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a Novel Fungal Triprenyl Phenol Metabolite by Hashimoto, Terumasa, Shibata, Keita, Nobe, Koji, Hasumi, Keiji, Honda, Kazuo

“…The aim of the present study was to establish a novel embolic model of cerebral infarction and to evaluate the effect of Stachybotrys microspora triprenyl…”
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Two distinct dysfunctions in diabetic mouse mesenteric artery contraction are caused by changes in the Rho A–Rho kinase signaling pathway by Nobe, Koji, Hashimoto, Terumasa, Honda, Kazuo

“…Diabetic complications are associated with small artery dysfunctions. The objective of this study was to identify differences in endothelial cell-denuded…”
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Change in soluble epoxide hydrolase (sEH) during cisplatin-induced acute renal failure in mice by Hashimoto, Terumasa, Fang, Yang-Il, Ohata, Hisayuki, Honda, Kazuo

“…Cisplatin is one of the most effective chemotherapeutic agents against various types of cancers; however, it is also associated with nephrotoxicity. Recently,…”
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A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice by Shibata, Keita, Hashimoto, Terumasa, Nobe, Koji, Hasumi, Keiji, Honda, Kazuo

“…Tissue plasminogen activator (t-PA) has a short therapeutic time window for administration (3 h) and carries a risk of promoting intracerebral hemorrhage. The…”
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Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice by Shibata, Keita, Hashimoto, Terumasa, Nobe, Koji, Hasumi, Keiji, Honda, Kazuo

“…Reactive oxygen species (ROS) formation has been found to induce the brain damage following stroke-like events. The aim of the present study was to investigate…”
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Glucose-dependent enhancement of diabetic bladder contraction is associated with a rho kinase-regulated protein kinase C pathway by Nobe, Koji, Yamazaki, Taigi, Tsumita, Naoki, Hashimoto, Terumasa, Honda, Kazuo

“…Urinary bladder dysfunction, which is one of the most common diabetic complications, is associated with alteration of bladder smooth muscle contraction…”
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Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors by Hashimoto, Terumasa, Ohata, Hisayuki, Honda, Kazuo

“…Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity…”
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Lysophosphatidic Acid Enhances In Vivo Infiltration and Activation of Guinea Pig Eosinophils and Neutrophils via a Rho/Rho-Associated Protein Kinase-Mediated Pathway by Hashimoto, Terumasa, Yamashita, Miyuki, Ohata, Hisayuki, Momose, Kazutaka

“…Lysophosphatidic acid (LPA) has been shown to be a chemoattractant in in vitro studies. The present study was carried out to determine whether LPA enhances…”
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Comparative Study of Calcium Ion Dynamics and Contractile Response in Rat Middle Cerebral and Basilar Arteries by Hashimoto, Terumasa, Ohata, Hisayuki, Nobe, Koji, Honda, Kazuo

“…The objective of this study was to compare intracellular calcium concentration ([Ca2+]i) and contractile responses in isolated rat middle cerebral artery (MCA)…”
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The Establishment of Acetic Acid‐Induced Cerebral Infarct Model, and Evaluation of Tissue Plasminogen Activator (t‐PA), Edaravone, Argatroban and Ticlopidine by Shibata, Keita, Hashimoto, Terumasa, Nobe, Koji, Ohata, Hisayuki, Honda, Kazuo

“…Abstract only…”
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Itch-scratch responses induced by lysophosphatidic acid in mice by Hashimoto, Terumasa, Ohata, Hisayuki, Momose, Kazutaka

“…The present investigation was conducted in order to determine whether lysophosphatidic acid (LPA) induces itch-scratch responses (ISRs) in mice. Intradermal…”
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