Search Results - "Hashimoto, Carl"

Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila by Tang, Huaping, Kambris, Zakaria, Lemaitre, Bruno, Hashimoto, Carl

“…The melanization reaction is used as an immune mechanism in arthropods to encapsulate and kill microbial pathogens. In Drosophila, the serpin Spn27A regulates…”
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Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation by Scherfer, Christoph, Tang, Huaping, Kambris, Zakaria, Lhocine, Nouara, Hashimoto, Carl, Lemaitre, Bruno

“…In insects the enzyme phenoloxidase (PO) catalyzes melanin deposition at the wound site and around parasitoid eggs. Its proenzyme prophenoloxidase (proPO) is…”
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Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila by Hyun, Joogyung, Hashimoto, Carl

“…Insulin-degrading enzyme (IDE) degrades insulin and other peptides, including the Aβ peptide of Alzheimer's disease. However, the mechanism by which IDE acts…”
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Spatial Regulation of Developmental Signaling by a Serpin by Hashimoto, Carl, Kim, Dong Ryoung, Weiss, Linnea A, Miller, Jingjing W, Morisato, Donald

“…An extracellular serine protease cascade generates the ligand that activates the Toll signaling pathway to establish dorsoventral polarity in the Drosophila…”
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Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin by Richer, M.J, Keays, C.A, Waterhouse, J, Minhas, J, Hashimoto, C, Jean, F

“…Proprotein convertases (PCs) are an important class of host-cell serine endoproteases implicated in many physiological and pathological processes. Owing to…”
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The Divergent U12-Type Spliceosome Is Required for Pre-mRNA Splicing and Is Essential for Development in Drosophila by Otake, Leo R., Scamborova, Petra, Hashimoto, Carl, Steitz, Joan A.

“…A minor class of pre-mRNA introns whose excision requires a spliceosome containing U11, U12, U4atac/U6atac, and U5 snRNPs has been identified in plants,…”
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Activation of a Protease Cascade Involved in Patterning the Drosophila Embryo by LeMosy, Ellen K., Tan, Yue-Qing, Hashimoto, Carl

“…Dorsoventral patterning of the Drosophila embryo is initiated by a ventralizing signal. Production of this signal requires the serine proteases Gastrulation…”
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The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein by Hashimoto, C, Hudson, K L, Anderson, K V

“…The Toll gene of Drosophila, a maternal effect gene that plays a central role in the establishment of the embryonic dorsal-ventral pattern, has been cloned…”
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Serpin Mechanism of Hepatitis C Virus Nonstructural 3 (NS3) Protease Inhibition by Richer, Martin J., Juliano, Luiz, Hashimoto, Carl, Jean, François

“…Hepatitis C virus (HCV) nonstructural 3 (NS3) serine protease disrupts important cellular antiviral signaling pathways and plays a pivotal role in the…”
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A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila by Tang, Huaping, Kambris, Zakaria, Lemaitre, Bruno, Hashimoto, Carl

“…Epithelial tissues facing the external environment are essential to combating microbial infection. In addition to providing a physical barrier, epithelial…”
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Gastrulation Defective Is a Serine Protease Involved in Activating the Receptor Toll to Polarize the Drosophila Embryo by Han, Jin-Hua, Lee, Si Hyoung, Tan, Yue-Qing, LeMosy, Ellen K., Hashimoto, Carl

“…The dorsoventral axis of the Drosophila embryo is induced by a ventrally restricted ligand for the receptor Toll. The Toll ligand is generated by a proteolytic…”
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A Spätzle-Processing Enzyme Required for Toll Signaling Activation in Drosophila Innate Immunity by Jang, In-Hwan, Chosa, Naoyuki, Kim, Sung-Hee, Nam, Hyuck-Jin, Lemaitre, Bruno, Ochiai, Masanori, Kambris, Zakaria, Brun, Sylvain, Hashimoto, Carl, Ashida, Masaaki, Brey, Paul T., Lee, Won-Jae

“…The Toll receptor was originally identified as an indispensable molecule for Drosophila embryonic development and subsequently as an essential component of…”
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A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila by Tang, Huaping, Kambris, Zakaria, Lemaitre, Bruno, Hashimoto, Carl

“…Epithelial tissues facing the external environment are essential to combating microbial infection. In addition to providing a physical barrier, epithelial…”
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The Nudel Protease of Drosophila Is Required for Eggshell Biogenesis in Addition to Embryonic Patterning by LeMosy, Ellen K., Hashimoto, Carl

“…The dorsoventral axis of the Drosophila embryo is defined by a ventral signal that arises within the perivitelline space, an extracellular compartment between…”
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An unusual mosaic protein with a protease domain, encoded by the nudeI gene, is involved in defining embryonic dorsoventral polarity in Drosophila by Hong, Charles C, Hashimoto, Carl

“…Dorsoventral polarity of the Drosophila embryo is induced by a ventral extracellular signal, which is produced by a locally activated protease cascade within…”
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Signal transduction by a protease cascade by LeMosy, Ellen K, Hong, Charles C, Hashimoto, Carl

“…The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo…”
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Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity by Richer, Martin J, Juliano, Luiz, Hashimoto, Carl, Jean, François

“…Hepatitis C virus (HCV) nonstructural 3 (NS3) serine protease disrupts important cellular antiviral signaling pathways and plays a pivotal role in the…”
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Evidence for a glycosaminoglycan on the nudel protein important for dorsoventral patterning of the drosophila embryo by Turcotte, Cynthia L., Hashimoto, Carl

“…Dorsoventral patterning of the Drosophila embryo requires Nudel, a large mosaic protein with a protease domain. Previous studies have implicated Nudel's…”
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The Drosophila Toll Gene Functions Zygotically and Is Necessary for Proper Motoneuron and Muscle Development by Halfon, Marc S., Hashimoto, Carl, Keshishian, Haig

“…Toll is a maternally required Drosophila gene that encodes a transmembrane protein with an important function in embryonic dorsal-ventral patterning. The Toll…”
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Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryo by LeMosy, E K, Kemler, D, Hashimoto, C

“…The establishment of embryonic dorsoventral polarity in Drosophila depends on a signaling mechanism in which the signal for ventral development is locally…”
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