Promomycin, a polyether promoting antibiotic production in Streptomyces spp

Promomycin, a polyether promoting antibiotic production in Streptomyces spp

Widespread interspecific stimulation of antibiotic production occurs in strains of Streptomyces owing to the activity of diffusible substances, as previously determined in our investigations of the cross-feeding effect. In this study, we newly isolated a substance produced by a Streptomyces strain c...

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Bibliographic Details
Published in:Journal of antibiotics Vol. 63; no. 8; pp. 486 - 491
Main Authors: Amano, Sho-ichi, Morota, Tatsuya, Kano, Yu-ki, Narita, Hiroyuki, Hashidzume, Tohko, Yamamoto, Setsuya, Mizutani, Kotaro, Sakuda, Shohei, Furihata, Kazuo, Takano-Shiratori, Hatsumi, Takano, Hideaki, Beppu, Teruhiko, Ueda, Kenji
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01-08-2010
Nature Publishing Group
Subjects:
631/326/22/1290
631/326/41
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiosis
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Life Sciences
Medicinal Chemistry
Microbiology
Organic Chemistry
original-article
Streptomyces - drug effects
Streptomyces - metabolism
polyether
promomycin
antibiotic production
ionophore
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Summary:Widespread interspecific stimulation of antibiotic production occurs in strains of Streptomyces owing to the activity of diffusible substances, as previously determined in our investigations of the cross-feeding effect. In this study, we newly isolated a substance produced by a Streptomyces strain closely related to Streptomyces scabrisporus , based on the observation that this substance induced the production of an unknown antibiotic in another strain related to Streptomyces griseorubiginosus . This substance, named promomycin, is a polyether structurally related to lonomycin. Promomycin itself had an antibiotic activity, but it stimulated antibiotic production in multiple Streptomyces strains at sub-inhibitory concentrations. Evidence implies that this stimulation effect is widespread within this group of bacteria.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2010.68