Search Results - "Hasegawa, Takuro"

Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5′-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species by Kuwagata, Makiko, Hasegawa, Takuro, Takashima, Hiromasa, Shimizu, Makiko, Kitajima, Satoshi, Yamazaki, Hiroshi

“…The teratogenicity of the chemotherapeutic drug thalidomide is species-specific and affects humans, non-human primates, and rabbits. The primary oxidation of…”
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Interindividual variations in metabolism and pharmacokinetics of 3-(6-methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a glucokinase activator, in rats caused by the genetic polymorphism of CYP2D1 by Hasegawa, Takuro, Eiki, Jun-ichi, Chiba, Masato

“…3-(6-Methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide (Cpd-D) is a novel glucokinase activator…”
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The PPARgamma-selective ligand BRL-49653 differentially regulates the fate choices of rat calvaria versus rat bone marrow stromal cell populations by Hasegawa, Takuro, Oizumi, Kiyoshi, Yoshiko, Yuji, Tanne, Kazuo, Maeda, Norihiko, Aubin, Jane E

“…Osteoblasts and adipocytes are derived from a common mesenchymal progenitor and an inverse relationship between expression of the two lineages is seen with…”
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Fibroblast growth factor-2 augments recombinant human bone morphogenetic protein-2-induced osteoinductive activity by Tanaka, Eiji, Ishino, Yoshihiro, Sasaki, Akiko, Hasegawa, Takuro, Watanabe, Mineo, Dalla-Bona, Diego A, Yamano, Eizo, van Eijden, Theo M G J, Tanne, Kazuo

“…The osteoinductive activity induced by recombinant human BMP-2 (rhBMP-2) blunts proportionately as the recipient ages. In order to compensate for this…”
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Skeletal anchorage for orthodontic correction of severe maxillary protrusion after previous orthodontic treatment by Tanaka, Eiji, Nishi-Sasaki, Akiko, Hasegawa, Takuro, Nishio, Clarice, Kawai, Nobuhiko, Tanne, Kazuo

“…The correction of a severe maxillary protrusion in an adult by distal movement of the maxillary molars has been one of the most difficult biomechanical…”
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Extracellular Vesicle Small RNAs derived from Mouse Amniotic Fluid Induced by Oral Administration of valproic acid (VPA), a reproductive developmental toxicant, to Pregnant Mice by Ono, Ryuichi, KUWAGATA, Makiko, Mie, N.A.R.U.S.E., WATANABE, Akihito, TAKANO, Masao, HASEGAWA, Takuro, TAKASHIMA, Hiromasa, YOSHIOKA, Yusuke, OCHIYA, Takahiro, HIRABAYASHI, Yoko, KITAJIMA, Satoshi

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A subset of osteoblasts expressing high endogenous levels of PPARgamma switches fate to adipocytes in the rat calvaria cell culture model by Yoshiko, Yuji, Oizumi, Kiyoshi, Hasegawa, Takuro, Minamizaki, Tomoko, Tanne, Kazuo, Maeda, Norihiko, Aubin, Jane E

“…Understanding fate choice and fate switching between the osteoblast lineage (ObL) and adipocyte lineage (AdL) is important to understand both the developmental…”
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Discovery of potent and orally active 3-alkoxy-5-phenoxy- N-thiazolyl benzamides as novel allosteric glucokinase activators by Iino, Tomoharu, Tsukahara, Daisuke, Kamata, Kenji, Sasaki, Kaori, Ohyama, Sumika, Hosaka, Hideka, Hasegawa, Takuro, Chiba, Masato, Nagata, Yasufumi, Eiki, Jun-ichi, Nishimura, Teruyuki

“…Identification and synthesis of novel 3-alkoxy-5-phenoxy- N-thiazolyl benzamide glucokinase activators are described. Identification and synthesis of novel…”
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Structure–activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy by Iino, Tomoharu, Hashimoto, Noriaki, Sasaki, Kaori, Ohyama, Sumika, Yoshimoto, Riki, Hosaka, Hideka, Hasegawa, Takuro, Chiba, Masato, Nagata, Yasufumi, Eiki, Jun-ichi, Nishimura, Teruyuki

“…The structure–activity relationships of 3,5-disubstituted benzamide glucokinase activators are described. The optimization of our lead GK activator 2a to 3-[(1…”
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A Subset of Osteoblasts Expressing High Endogenous Levels of PPARγ Switches Fate to Adipocytes in the Rat Calvaria Cell Culture Model by Yoshiko, Yuji, Oizumi, Kiyoshi, Hasegawa, Takuro, Minamizaki, Tomoko, Tanne, Kazuo, Maeda, Norihiko, Aubin, Jane E.

“…Background Understanding fate choice and fate switching between the osteoblast lineage (ObL) and adipocyte lineage (AdL) is important to understand both the…”
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Metabolic activation of N-thiazol-2-yl benzamide as glucokinase activators: Impacts of glutathione trapping on covalent binding by Iino, Tomoharu, Hashimoto, Noriaki, Hasegawa, Takuro, Chiba, Masato, Eiki, Jun-ichi, Nishimura, Teruyuki

“…The in vitro covalent binding results that were observed during the course of evaluating the compound 3 for the treatment of type-2 diabetes are described…”
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A Subset of Osteoblasts Expressing High Endogenous Levels of PPAR[gamma] Switches Fate to Adipocytes in the Rat Calvaria Cell Culture Model by Yoshiko, Yuji, Oizumi, Kiyoshi, Hasegawa, Takuro, Minamizaki, Tomoko, Tanne, Kazuo, Maeda, Norihiko, Aubin, Jane E

“…Background Understanding fate choice and fate switching between the osteoblast lineage (ObL) and adipocyte lineage (AdL) is important to understand both the…”
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Dynamic shear behavior of mandibular condylar cartilage is dependent on testing direction by Tanaka, Eiji, Iwabuchi, Yasunori, Rego, Emanuel B, Koolstra, Jan Harm, Yamano, Eizo, Hasegawa, Takuro, Kawazoe, Aki, Kawai, Nobuhiko, Tanne, Kazuo

“…Abstract Little information is available on the direction-dependency of shear behavior in mandibular condylar cartilage. Therefore, we tested the hypothesis…”
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Short communication: Dynamic shear behavior of mandibular condylar cartilage is dependent on testing direction by Tanaka, Eiji, Iwabuchi, Yasunori, Rego, Emanuel B, Koolstra, Jan Harm, Yamano, Eizo, Hasegawa, Takuro, Kawazoe, Aki, Kawai, Nobuhiko, Tanne, Kazuo

“…Little information is available on the direction-dependency of shear behavior in mandibular condylar cartilage. Therefore, we tested the hypothesis that such a…”
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Muscarinic M3 receptor antagonists with (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxyphenylacetamide structures. Part 2 by OGINO, Yoshio, OHTAKE, Norikazu, KOBAYASHI, Kensuke, KIMURA, Toshifumi, FUJIKAWA, Toru, HASEGAWA, Takuro, NOGUCHI, Kazuhito, MASE, Toshiaki

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Severe crowding and a dilacerated maxillary central incisor in an adolescent by Tanaka, Eiji, Hasegawa, Takuro, Hanaoka, Koichi, Yoneno, Kiyoshi, Matsumoto, Eka, Dalla-Bona, Diego, Yamano, Eizo, Suekawa, Yohei, Watanabe, Mineo, Tanne, Kazuo

“…This study reports the treatment of an adolescent patient with dilacerated maxillary incisor. She complained of severe crowding with a high-positioned left…”
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A Subset of Osteoblasts Expressing High Endogenous Levels of PPARg Switches Fate to Adipocytes in the Rat Calvaria Cell Culture Model by Yoshiko, Yuji, Oizumi, Kiyoshi, Hasegawa, Takuro, Minamizaki, Tomoko, Tanne, Kazuo, Maeda, Norihiko, Aubin, Jane E

“…Understanding fate choice and fate switching between the osteoblast lineage (ObL) and adipocyte lineage (AdL) is important to understand both the developmental…”
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A Potent, Long-Acting, Orally Active (2 R )-2-[(1 R )-3,3-Difluorocyclopentyl]-2-hydroxy-2-phenylacetamide:  A Novel Muscarinic M 3 Receptor Antagonist with High Selectivity for M 3 over M 2 Receptors by Mitsuya, Morihiro, Kobayashi, Kensuke, Kawakami, Kumiko, Satoh, Atsushi, Ogino, Yoshio, Kakikawa, Taro, Ohtake, Norikazu, Kimura, Toshifumi, Hirose, Hiroyasu, Sato, Akio, Numazawa, Tomosige, Hasegawa, Takuro, Noguchi, Kazuhito, Mase, Toshiaki

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A Potent, Long-Acting, Orally Active (2R)-2-[(1R)-3,3-Difluorocyclopentyl]-2-hydroxy-2-phenylacetamide:  A Novel Muscarinic M3 Receptor Antagonist with High Selectivity for M3 over M2 Receptors by Mitsuya, Morihiro, Kobayashi, Kensuke, Kawakami, Kumiko, Satoh, Atsushi, Ogino, Yoshio, Kakikawa, Taro, Ohtake, Norikazu, Kimura, Toshifumi, Hirose, Hiroyasu, Sato, Akio, Numazawa, Tomosige, Hasegawa, Takuro, Noguchi, Kazuhito, Mase, Toshiaki

“…A novel series of (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamides was designed and synthesized based on the structure and biological…”
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Muscarinic M(3) receptor antagonists with (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxyphenylacetamide Structures. Part 2 by Ogino, Yoshio, Ohtake, Norikazu, Kobayashi, Kensuke, Kimura, Toshifumi, Fujikawa, Toru, Hasegawa, Takuro, Noguchi, Kazuhito, Mase, Toshiaki

“…Optimization of the amine part of our original muscarinic M(3) receptor antagonist 1 was performed to identify M(3) receptor antagonists that are superior to…”
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