Search Results - "Hasegawa, Kazuteru"

Retinoic acid signaling in Sertoli cells regulates organization of the blood-testis barrier through cyclical changes in gene expression by Hasegawa, Kazuteru, Saga, Yumiko

“…Mammalian spermatogenesis contributes a constant production of large numbers of spermatozoa, which is achieved by a cyclically regulated program known as the…”
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MEK/ERK signaling directly and indirectly contributes to the cyclical self‐renewal of spermatogonial stem cells by Hasegawa, Kazuteru, Namekawa, Satoshi H., Saga, Yumiko

“…Coordination of stem cell fate is regulated by extrinsic niche signals and stem cell intrinsic factors. In mammalian testes, spermatogonial stem cells maintain…”
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NANOS2 Acts Downstream of Glial Cell Line-Derived Neurotrophic Factor Signaling to Suppress Differentiation of Spermatogonial Stem Cells by Sada, Aiko, Hasegawa, Kazuteru, Pin, Pui Han, Saga, Yumiko

“…Stem cells are maintained by both stem cell‐extrinsic niche signals and stem cell‐intrinsic factors. During murine spermatogenesis, glial cell line‐derived…”
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Polycomb directs timely activation of germline genes in spermatogenesis by Maezawa, So, Hasegawa, Kazuteru, Yukawa, Masashi, Sakashita, Akihiko, Alavattam, Kris G, Andreassen, Paul R, Vidal, Miguel, Koseki, Haruhiko, Barski, Artem, Namekawa, Satoshi H

“…During spermatogenesis, a large number of germline genes essential for male fertility are coordinately activated. However, it remains unknown how timely…”
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Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline by Maezawa, So, Hasegawa, Kazuteru, Yukawa, Masashi, Kubo, Naoki, Sakashita, Akihiko, Alavattam, Kris G., Sin, Ho-Su, Kartashov, Andrey V., Sasaki, Hiroyuki, Barski, Artem, Namekawa, Satoshi H.

“…Repressive H3K27me3 and active H3K4me2/3 together form bivalent chromatin domains, molecular hallmarks of developmental potential. In the male germline, these…”
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SCML2 promotes heterochromatin organization in late spermatogenesis by Maezawa, So, Hasegawa, Kazuteru, Alavattam, Kris G, Funakoshi, Mayuka, Sato, Taiga, Barski, Artem, Namekawa, Satoshi H

“…Spermatogenesis involves the progressive reorganization of heterochromatin. However, the mechanisms that underlie the dynamic remodeling of heterochromatin…”
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RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells by Zhou, Zhi, Shirakawa, Takayuki, Ohbo, Kazuyuki, Sada, Aiko, Wu, Quan, Hasegawa, Kazuteru, Saba, Rie, Saga, Yumiko

“…In many adult tissues, homeostasis relies on self-renewing stem cells that are primed for differentiation. The reconciliation mechanisms of these…”
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SCML2 Establishes the Male Germline Epigenome through Regulation of Histone H2A Ubiquitination by Hasegawa, Kazuteru, Sin, Ho-Su, Maezawa, So, Broering, Tyler J., Kartashov, Andrey V., Alavattam, Kris G., Ichijima, Yosuke, Zhang, Fan, Bacon, W. Clark, Greis, Kenneth D., Andreassen, Paul R., Barski, Artem, Namekawa, Satoshi H.

“…Gametogenesis is dependent on the expression of germline-specific genes. However, it remains unknown how the germline epigenome is distinctly established from…”
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Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline by Sin, Ho-Su, Kartashov, Andrey V, Hasegawa, Kazuteru, Barski, Artem, Namekawa, Satoshi H

“…The male germline transcriptome changes dramatically during the mitosis-to-meiosis transition to activate late spermatogenesis genes and to transiently…”
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Notch Signaling in Sertoli Cells Regulates Cyclical Gene Expression of Hes1 but Is Dispensable for Mouse Spermatogenesis by Hasegawa, Kazuteru, Okamura, Yoshiaki, Saga, Yumiko

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High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells by Pech, Matthew F, Garbuzov, Alina, Hasegawa, Kazuteru, Sukhwani, Meena, Zhang, Ruixuan J, Benayoun, Bérénice A, Brockman, Stephanie A, Lin, Shengda, Brunet, Anne, Orwig, Kyle E, Artandi, Steven E

“…Telomerase inactivation causes loss of the male germline in worms, fish, and mice, indicating a conserved dependence on telomere maintenance in this cell…”
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FGF8-FGFR1 Signaling Acts as a Niche Factor for Maintaining Undifferentiated Spermatogonia in the Mouse1 by Hasegawa, Kazuteru, Saga, Yumiko

“…In mammalian testes, spermatogonial stem cells (SSCs) maintain spermatogenesis over a long period of time by undergoing self-renewal and differentiation. SSCs…”
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BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis by Broering, Tyler J, Alavattam, Kris G, Sadreyev, Ruslan I, Ichijima, Yosuke, Kato, Yasuko, Hasegawa, Kazuteru, Camerini-Otero, R Daniel, Lee, Jeannie T, Andreassen, Paul R, Namekawa, Satoshi H

“…During meiosis, DNA damage response (DDR) proteins induce transcriptional silencing of unsynapsed chromatin, including the constitutively unsynapsed XY…”
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PRC1 suppresses a female gene regulatory network to ensure testicular differentiation by Maezawa, So, Yukawa, Masashi, Hasegawa, Kazuteru, Sugiyama, Ryo, Iizuka, Mizuho, Hu, Mengwen, Sakashita, Akihiko, Vidal, Miguel, Koseki, Haruhiko, Barski, Artem, DeFalco, Tony, Namekawa, Satoshi H.

“…Gonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In testes, the…”
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NANOS3 suppresses premature spermatogonial differentiation to expand progenitors and fine-tunes spermatogenesis in mice by Inoue, Hiroki, Sakurai, Takayuki, Hasegawa, Kazuteru, Suzuki, Atsushi, Saga, Yumiko

“…In the mouse testis, sperm originate from spermatogonial stem cells (SSCs). SSCs give rise to spermatogonial progenitors, which expand their population until…”
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Purification of GFRα1+ and GFRα1– Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination by Garbuzov, Alina, Pech, Matthew F., Hasegawa, Kazuteru, Sukhwani, Meena, Zhang, Ruixuan J., Orwig, Kyle E., Artandi, Steven E.

“…Undifferentiated spermatogonia comprise a pool of stem cells and progenitor cells that show heterogeneous expression of markers, including the cell surface…”
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MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion by Zhang, Chuan, Moriguchi, Takashi, Kajihara, Miwako, Esaki, Ritsuko, Harada, Ayako, Shimohata, Homare, Oishi, Hisashi, Hamada, Michito, Morito, Naoki, Hasegawa, Kazuteru, Kudo, Takashi, Engel, James Douglas, Yamamoto, Masayuki, Takahashi, Satoru

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MafB Is Essential for Renal Development and F4/80 Expression in Macrophages by Moriguchi, Takashi, Hamada, Michito, Morito, Naoki, Terunuma, Tsumoru, Hasegawa, Kazuteru, Zhang, Chuan, Yokomizo, Tomomasa, Esaki, Ritsuko, Kuroda, Etsushi, Yoh, Keigyou, Kudo, Takashi, Nagata, Michio, Greaves, David R., Engel, James Douglas, Yamamoto, Masayuki, Takahashi, Satoru

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Runx1 is involved in primitive erythropoiesis in the mouse by Yokomizo, Tomomasa, Hasegawa, Kazuteru, Ishitobi, Hiroyuki, Osato, Motomi, Ema, Masatsugu, Ito, Yoshiaki, Yamamoto, Masayuki, Takahashi, Satoru

“…Targeted disruption of the Runx1/ AML1 gene in mice has demonstrated that it is required for the emergence of definitive hematopoietic cells but that it is not…”
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c-Maf is essential for the F4/80 expression in macrophages in vivo by Nakamura, Megumi, Hamada, Michito, Hasegawa, Kazuteru, Kusakabe, Manabu, Suzuki, Hirona, Greaves, David R., Moriguchi, Takashi, Kudo, Takashi, Takahashi, Satoru

“…c-Maf, which is one of the large Maf transcription factors, can bind to Maf recognition element (MARE) and activates transcription of target genes. Although…”
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