Search Results - "Hasani, Sumati"

Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer by Guo, Bianqin, Xiong, Xiaopeng, Hasani, Sumati, Wen, Yang-An, Li, Austin T., Martinez, Rebecca, Skaggs, Ashley T., Gao, Tianyan

“…Aberrant activation of endoplasmic reticulum (ER) stress by extrinsic and intrinsic factors contributes to tumorigenesis and resistance to chemotherapies in…”
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Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer by Hasani, Sumati, Young, Lyndsay E. A., Van Nort, Warren, Banerjee, Moumita, Rivas, Dylan R., Kim, Jinhwan, Xiong, Xiaopeng, Sun, Ramon C., Gentry, Matthew S., Sesaki, Hiromi, Gao, Tianyan

“…Metabolic reprogramming has been recognized as one of the major mechanisms that fuel tumor initiation and progression. Our previous studies demonstrate that…”
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Abstract 1428 The Role of Mitochondrial Fission in Regulating DNA Damage Response in Colorectal Cancer by Evers, Benjamin, Kim, Jinhwan, Hasani, Sumati, Gao, Tianyan

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The role of PHLPP in regulating mitochondrial dynamics in colorectal cancer by Hasani, Sumati R., Xiong, Xiaopeng, Gao, Tianyan

“…Abstract only Colorectal cancer (CRC) is the second leading cause of cancer deaths in men and women combined in the United States. According to the American…”
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Abstract 1644 Regulation of Protein Tyrosine Phosphatase Receptor Type F by NEDD4L E3 Ligase by Stanczyk, Haley, Skaggs, Ashley, Kim, Jinhwan, Hasani, Sumati, Rivas, Dylan, Gao, Tianyan

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Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer by Xiong, Xiaopeng, Hasani, Sumati, Young, Lyndsay E. A., Rivas, Dylan R., Skaggs, Ashley T., Martinez, Rebecca, Wang, Chi, Weiss, Heidi L., Gentry, Matthew S., Sun, Ramon C., Gao, Tianyan

“…Cancer cells are known for their ability to adapt variable metabolic programs depending on the availability of specific nutrients. Our previous studies have…”
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Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1 + Activated T Cells by Dovedi, Simon J, Elder, Matthew J, Yang, Chunning, Sitnikova, Suzanne I, Irving, Lorraine, Hansen, Anna, Hair, James, Jones, Des C, Hasani, Sumati, Wang, Bo, Im, Seock-Ah, Tran, Ben, Subramaniam, Deepa S, Gainer, Shelby D, Vashisht, Kapil, Lewis, Arthur, Jin, Xiaofang, Kentner, Stacy, Mulgrew, Kathy, Wang, Yaya, Overstreet, Michael G, Dodgson, James, Wu, Yanli, Palazon, Asis, Morrow, Michelle, Rainey, Godfrey J, Browne, Gareth J, Neal, Frances, Murray, Thomas V, Toloczko, Aleksandra D, Dall'Acqua, William, Achour, Ikbel, Freeman, Daniel J, Wilkinson, Robert W, Mazor, Yariv

“…The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events…”
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Abstract 7109: Fasn inhibition enhances the efficacy of chemotherapy by inhibiting DNA damage response in colorectal cancer by Banerjee, Moumita, Zaytseva, Yekaterina, Hasani, Sumati, Ryachahou, Piotr, Izumi, Tadahide, Evers, B. Mark, Gao, Tianyan

“…Abstract Altered lipid metabolism plays a significant role in progression of colorectal cancer, however, its role in chemotherapy resistance remains poorly…”
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Abstract 4837: Inhibition of mitochondrial fission activates glycogen storage to support cell survival in colon cancer by Hasani, Sumati, Young, Lyndsay E., Banerjee, Moumita, Rivas, Dylan, Kim, Jinhwan, Sun, Ramon, Gentry, Matthew, Xiong, Xiaopeng, Gao, Tianyan

“…Abstract Metabolic reprogramming has been increasingly recognized as one of the major mechanisms that fuels tumorigenesis and disease progression. Our previous…”
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Abstract 2776: MEDI5752: A novel bispecific antibody that preferentially targets CTLA-4 on PD-1 expressing T-cells by Dovedi, Simon J., Mazor, Yariv, Elder, Matthew, Hasani, Sumati, Wang, Bo, Mosely, Suzanne, Jones, Desmond, Hansen, Anna, Yang, Chuning, Wu, Yanli, Achour, Ikbel, Durham, Nick, Browne, Gareth, Murray, Thomas, Hair, James, Morrow, Michelle, Rainey, Godfrey, Kunkel, Maria Jure, Gooya, John, Freeman, Daniel, Herbst, Ronald, Wilkinson, Robert

“…Abstract Studies have demonstrated that the clinical benefit of PD-1 blockade can be further improved by combination with an αCTLA-4 mAb in some indications…”
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