Search Results - "Harvima, I."

Mast Cells as Regulators of Skin Inflammation and Immunity by HARVIMA, Ilkka T, NILSSON, Gunnar

“…Mast cells are known to be the effector cells of immediate-type allergy, but experimental evidence obtained during the last decade has revealed their role in…”
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Mast cell chymase degrades fibrinogen and fibrin by Lipitsä, T., Siiskonen, H., Naukkarinen, A., Harvima, I.T.

“…Summary Background The accumulation of immunoreactants and fibrinoid necrosis of postcapillary vessel walls are common pathological features of cutaneous…”
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Experimentally induced psoriatic lesion associates with interleukin (IL)‐6 in mast cells and appearance of dermal cells expressing IL‐33 and IL‐6 receptor by Suttle, M.‐M., Nilsson, G., Snellman, E., Harvima, I. T.

“…Summary Mast cells are involved in the development of psoriatic lesion, but it is not known how mast cells are activated or whether mast cell cytokines are…”
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Accuracy and reliability of a hand‐held in vivo skin indentation device to assess skin elasticity by Virén, T., Iivarinen, J. T., Sarin, J. K., Harvima, I., Mayrovitz, H. N.

“…Objective The aim of this study was to evaluate the performance of a hand‐held indentation device for fast and reliable determination of skin stiffness…”
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OX40 ligand and OX40 are increased in atopic dermatitis lesions but do not correlate with clinical severity by Ilves, T., Harvima, I.T.

“…Background  The interaction between the OX40 ligand (OX40L) and OX40 has been suggested to have pathogenetic significance in atopic dermatitis (AD). Objective …”
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Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors by Huttunen, M., Harvima, I.T.

“…Summary Background  Numerous mast cells are present in chronic leg ulcers. Tryptase and chymase are the major mediators of mast cells, but their significance…”
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Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-α and their degranulation is associated with expression of ICAM-1 in the epidermis by ACKERMANN, L, HARVIMA, I. T

“…The release of cytokines from cutaneous cells may be of major importance in the initiation and development of many inflammatory skin disorders. For example,…”
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The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma by Diaconu, N-C, Kaminska, R, Naukkarinen, A, Harvima, RJ, Harvima, IT

“…Background  In basal cell carcinoma (BCC), mast cells accumulate in the peritumoral stroma. The serine proteinases tryptase and chymase are the major mediators…”
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Mast cells in psoriatic skin are strongly positive for interferon-gamma by ACKERMANN, L, HARVIMA, I. T, PELKONEN, J, RITAMÄKI-SALO, V, NAUKKARINEN, A, HARVIMA, R. J, HORSMANHEIMO, M

“…The increased number and early activation of cutaneous mast cells is a typical feature of psoriatic inflammation. Interferon‐gamma (IFN‐γ) is believed to be…”
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Inhibition of keratinocyte growth in cell culture and whole skin culture by mast cell mediators by Huttunen, M., Hyttinen, M., Nilsson, G., Butterfield, J. H., Horsmanheimo, M., Harvima, I. T.

“…: Mast cells are suggested to participate in regenerative processes, but their influence on epithelialization and wound healing has not been well studied…”
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Quantitative analysis of tryptase and chymase containing mast cells in benign and malignant breast lesions by Kankkunen, Jussi‐Pekka, Harvima, Ilkka T., Naukkarinen, Anita

“…The aim of our work was to study the number and distribution of tryptase‐ and chymase‐containing mast cells in benign and malignant breast lesions. Tryptase…”
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Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2 by SAARINEN, J. V, HARVIMA, R. J, HORSMANHEIMO, M, HARVIMA, I. T

“…To study the effect of nordihydroguaiaretic acid (NDGA), zafirlukast and indomethacin on the size of the size of the allergic prick-test wheal. In the first…”
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Alterations in mast cells showing tryptase and chymase activity in epithelializating and chronic wounds by Huttunen, M., Aalto, M.-L., Harvima, R. J., Horsmanheimo, M., Harvima, I. T.

“…: Mast cells can be found in contact with epidermis in certain circumstances; especially in chronic inflammatory skin diseases and chronic ulcers, but the…”
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Juvenile-onset neuronal ceroid lipofuscinosis with infantile CLN1 mutation and palmitoyl-protein thioesterase deficiency by Kälviäinen, R., Eriksson, K., Losekoot, M., Sorri, I., Harvima, I., Santavuori, P., Järvelä, I., Autti, T., Vanninen, R., Salmenperä, T., Van Diggelen, O. P.

“…Accurate diagnosis, especially in progressive hereditary diseases, is essential for the treatment and genetic counseling of the patient and the family…”
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Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema by JÄRVIKALLIO, A., NAUKKARINEN, A., HARVIMA, I.T., AALTO, M.-L., HORSMANHEIMO, M.

“…Summary The distribution of mast cells (MCs) containing tryptase (T) and chymase (C) was studied in the non‐lesional and lesional skin of 26 patients with…”
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Focal Dermal–Epidermal Separation and Fibronectin Cleavage in Basement Membrane by Human Mast Cell Tryptase by Kaminska, Renata, Helisalmi, Petra, Harvima, Rauno J., Horsmanheimo, Maija, Harvima, Ilkka T, Naukkarinen, Anita

“…Mast cell proteases are believed to participate in the basement membrane destruction in blistering diseases. Thus, normal human skin specimens were incubated…”
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Mast cells are one major source of interleukin-4 in atopic dermatitis by Horsmanheimo, L, Harvima, I T, Järvikallio, A, Harvima, R J, Naukkarinen, A, Horsmanheimo, M

“…Several reports have shown the presence of T-helper lymphocytes with Th2 characteristics in the skin lesions of atopic dermatitis (AD). However, Th2 cells…”
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Water loss through the lip, nail, eyelid skin, scalp skin and axillary skin measured with a closed-chamber evaporation principle by Nuutinen, J., Harvima, I., Lahtinen, M-R., Lahtinen, T.

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QUANTITATIVE HISTOCHEMICAL ANALYSIS OF MAST CELLS AND SENSORY NERVES IN PSORIATIC SKIN by NAUKKARINEN, ANITA, JÄRVIKALLIO, ANITTA, LAKKAKORPI, JOUNI, HARVIMA, ILKKA T., HARVIMA, RAUNO J., HORSMANHEIMO, MAIJA

“…To study the elements of neurogenic inflammation in psoriatic skin, morphological contacts were examined between mast cells and sensory nerves containing the…”
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The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reaction in the skin by Saarinen, J. V., Harvima, R. J., Naukkarinen, A., Horsmanheimo, M., Harvima, I. T.

“…Background Chymase released by mast cells can participate in the immediate allergic wheal. However, chymase may be susceptible to inactivation by protease…”
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