Search Results - "Harvey, Richard P"
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Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
Published in eLife (26-03-2019)“…Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play key roles in heart repair, regeneration and disease, including…”
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Long Noncoding RNAs in Cardiac Development and Pathophysiology
Published in Circulation research (26-10-2012)“…Heart function requires sophisticated regulatory networks to orchestrate organ development, physiological responses, and environmental adaptation. Until…”
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Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
Published in Nature communications (29-01-2021)“…Endothelial cells play a critical role in the adaptation of tissues to injury. Tissue ischemia induced by infarction leads to profound changes in endothelial…”
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Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data
Published in Genome Biology (08-07-2020)“…Abstract High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene expression in single cells. Most current scRNA-seq bioinformatics…”
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Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation
Published in Nature (London) (01-05-2018)“…In vertebrate hearts, the ventricular trabecular myocardium develops as a sponge-like network of cardiomyocytes that is critical for contraction and…”
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Developmental origin and lineage plasticity of endogenous cardiac stem cells
Published in Development (Cambridge) (15-04-2016)“…Over the past two decades, several populations of cardiac stem cells have been described in the adult mammalian heart. For the most part, however, their…”
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Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Published in Science translational medicine (05-04-2017)“…The emerging standard of care for patients with inoperable pancreatic cancer is a combination of cytotoxic drugs gemcitabine and Abraxane, but patient response…”
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Congenital heart disease: current knowledge about causes and inheritance
Published in Medical journal of Australia (06-08-2012)“…About 80% of congenital heart disease (CHD) is multifactorial and arises through various combinations of genetic and environmental contributors. About 20% of…”
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Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair
Published in Circulation research (25-04-2014)“…RATIONALE:Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment, but appreciation of their…”
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Nkx2-5+Islet1+ Mesenchymal Precursors Generate Distinct Spleen Stromal Cell Subsets and Participate in Restoring Stromal Network Integrity
Published in Immunity (Cambridge, Mass.) (18-04-2013)“…Secondary lymphoid organ stromal cells comprise different subsets whose origins remain unknown. Herein, we exploit a genetic lineage-tracing approach to show…”
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Comparative regenerative mechanisms across different mammalian tissues
Published in npj Regenerative medicine (23-02-2018)“…Stimulating regeneration of complex tissues and organs after injury to effect complete structural and functional repair, is an attractive therapeutic option…”
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Single-cell transcriptome dynamics of the autotaxin-lysophosphatidic acid axis during muscle regeneration reveal proliferative effects in mesenchymal fibro-adipogenic progenitors
Published in Frontiers in cell and developmental biology (23-02-2023)“…Lysophosphatidic acid is a growth factor-like bioactive phospholipid recognising LPA receptors and mediating signalling pathways that regulate embryonic…”
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Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
Published in Cell stem cell (02-12-2011)“…Colony-forming units – fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs,…”
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Tissue-Resident PDGFRα+ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner
Published in Cell reports (Cambridge) (14-01-2020)“…PDGFRα+ mesenchymal progenitor cells are associated with pathological fibro-adipogenic processes. Conversely, a beneficial role for these cells during…”
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Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
Published in Proceedings of the National Academy of Sciences - PNAS (11-09-2007)“…Chemotactic cytokines (chemokines) attract immune cells, although their original evolutionary role may relate more closely with embryonic development. We noted…”
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Targeted Next-Generation Sequencing Identifies Pathogenic Variants in Familial Congenital Heart Disease
Published in Journal of the American College of Cardiology (16-12-2014)“…Abstract Background Many genes have been implicated in the development of congenital heart disease (CHD). Next-generation sequencing offers opportunities for…”
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Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types
Published in Cellular and molecular life sciences : CMLS (01-08-2014)“…Congenital heart defects represent the most common human birth defects and are often life-threatening. Frequently, they are caused by abnormalities of the…”
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Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium
Published in Proceedings of the National Academy of Sciences - PNAS (06-11-2012)“…During cardiogenesis, Fibroblast Growth Factor (Fgf10) is expressed in the anterior second heart field. Together with Fibroblast growth factor 8 (Fgf8), Fgf10…”
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Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia
Published in Stem cell research & therapy (27-07-2023)“…Atrial fibrillation is the most common arrhythmia syndrome and causes significant morbidity and mortality. Current therapeutics, however, have limited…”
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Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy
Published in PLoS genetics (06-07-2018)“…Left ventricular non-compaction (LVNC) is a rare cardiomyopathy associated with a hypertrabeculated phenotype and a large spectrum of symptoms. It is still…”
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