Search Results - "Harvey, R M"

Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons by Stan, Georgiana F., Church, Timothy W., Randall, Ellie, Harvey, Jenna R. M., Brown, Jon T., Wilkinson, Kevin A., Hanley, Jonathan G., Marrion, Neil V.

“…Accumulation of tau is observed in dementia, with human tau displaying 6 isoforms grouped by whether they display either 3 or 4 C-terminal repeat domains (3R…”
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Establishing the contribution of lawn mowing to atmospheric aerosol levels in American suburbs by Harvey, R. M, Zahardis, J, Petrucci, G. A

“…Green leaf volatiles (GLVs) are a class of wound-induced volatile organic compounds emitted by several plant species. Turf grasses emit a complex profile of…”
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Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability by Harvey, Jenna R M, Plante, Amber E, Meredith, Andrea L

“…Animals synchronize to the environmental day-night cycle by means of an internal circadian clock in the brain. In mammals, this timekeeping mechanism is housed…”
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An ecological view of psychological trauma and trauma recovery by Harvey, M R

“…This paper presents an ecological view of psychological trauma and trauma recovery. Individual differences in posttraumatic response and recovery are the…”
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Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells by Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.

“…Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited…”
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Somatic mutation rates scale with lifespan across mammals by Cagan, Alex, Baez-Ortega, Adrian, Brzozowska, Natalia, Abascal, Federico, Coorens, Tim H. H., Sanders, Mathijs A., Lawson, Andrew R. J., Harvey, Luke M. R., Bhosle, Shriram, Jones, David, Alcantara, Raul E., Butler, Timothy M., Hooks, Yvette, Roberts, Kirsty, Anderson, Elizabeth, Lunn, Sharna, Flach, Edmund, Spiro, Simon, Januszczak, Inez, Wrigglesworth, Ethan, Jenkins, Hannah, Dallas, Tilly, Masters, Nic, Perkins, Matthew W., Deaville, Robert, Druce, Megan, Bogeska, Ruzhica, Milsom, Michael D., Neumann, Björn, Gorman, Frank, Constantino-Casas, Fernando, Peachey, Laura, Bochynska, Diana, Smith, Ewan St. John, Gerstung, Moritz, Campbell, Peter J., Murchison, Elizabeth P., Stratton, Michael R., Martincorena, Iñigo

“…The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans 1 – 7 . Comparative analyses can shed light on the diversity…”
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Rumen degradable protein supply affects microbial efficiency in continuous culture and growth in steers by Brooks, M A, Harvey, R M, Johnson, N F, Kerley, M S

“…We hypothesized that microbial efficiency and output from fermentation in the rumen would be optimized when peptide supply was balanced with peptide…”
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Complications of varicose vein surgery by Critchley, G, Handa, A, Maw, A, Harvey, A, Harvey, M R, Corbett, C R

“…A retrospective review was carried out of patients who had undergone surgery for varicose veins over an 8 year period between 1985 and 1993. We wished to…”
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Multielectrode Arrays by Burley, Russell, Harvey, Jenna R M

“…Multielectrode arrays (MEAs) are grids of substrate-integrated microelectrodes that allow for electrophysiological interrogation of dissociated cell cultures…”
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Adult memories of childhood trauma: a naturalistic clinical study by Herman, J L, Harvey, M R

“…The clinical evaluations of 77 adult psychiatric outpatients reporting memories of childhood trauma were reviewed. A majority of patients reported some degree…”
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Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction by Christie, Louisa A., Brice, Nicola L., Rowland, Anna, Dickson, Louise, Anand, Rishi, Teall, Martin, Doyle, Kevin J., Narayana, Lakshminarayana, Mitchell, Christine, Harvey, Jenna R. M., Mulligan, Victoria, Dawson, Lee A., Cragg, Stephanie J., Carlton, Mark, Bürli, Roland W.

“…Nicotinic acetylcholine receptor (nAChR) α6 subunit RNA expression is relatively restricted to midbrain regions and is located presynaptically on dopaminergic…”
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Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome by Ossola, Bernardino, Rifat, Ali, Rowland, Anna, Hunter, Helen, Drinkall, Samuel, Bender, Clare, Hamlischer, Mayida, Teall, Martin, Burley, Russell, Barker, Daneil F., Cadwalladr, David, Dickson, Louise, Lawrence, Jason M.K., Harvey, Jenna R.M., Lizio, Marina, Xu, Xiao, Kavanagh, Edel, Cheung, Toni, Sheardown, Steve, Lawrence, Catherine B., Harte, Michael, Brough, David, Madry, Christian, Matthews, Kim, Doyle, Kevin, Page, Keith, Powell, Justin, Brice, Nicola L., Bürli, Roland W., Carlton, Mark B., Dawson, Lee A.

“…Neuroinflammation, specifically the NLRP3 inflammasome cascade, is a common underlying pathological feature of many neurodegenerative diseases. Evidence…”
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Effect of environmental stress during tuber development on accumulation of glycoalkaloids in potato (Solanum tuberosum L) by Papathanasiou, Fokion, Mitchell, Samuel H, Watson, Sally, Harvey, Barbara M R

“…The effects of low temperature and of combined stresses, cool temperature and waterlogging and also warm temperature and drought, on potato tuber glycoalkaloid…”
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Variation in glycoalkaloid concentration of potato tubers harvested from mature plants by Papathanasiou, Fokion, Mitchell, Samuel H, Harvey, Barbara M R

“…Individual tubers from mature plants of cultivars Pentland Dell and Estima were harvested from experimental plots in two successive years and analysed for…”
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The human placenta exhibits a unique transcriptomic void by Gong, Sungsam, Gaccioli, Francesca, Aye, Irving L.M.H., Avellino, Giulia, Cook, Emma, Lawson, Andrew R.J., Harvey, Luke M.R., Smith, Gordon C.S., Charnock-Jones, D. Stephen

“…The human placenta exhibits a unique genomic architecture with an unexpectedly high mutation burden and many uniquely expressed genes. The aim of this study is…”
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Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment by Bürli, Roland W., Doyle, Kevin J., Dickson, Louise, Rowland, Anna, Matthews, Kim, Stott, Andrew J., Teall, Martin, Ossola, Bernardino, Russell, Samuel G., Harvey, Jenna R. M., Wu, Yiming, Narayana, Lakshminarayana, Brice, Nicola L., Carlton, Mark, Dawson, Lee A.

“…The potassium (K+) ion channel KCNK13 is specifically expressed in human microglia with elevated expression observed in post-mortem human brain tissue from…”
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Decision-making preference and opportunity in VA ambulatory care patients: Association with patient satisfaction by Harvey, Rose M., Kazis, Lewis, Lee, Austin F. S.

“…Using data from the Veterans Health Study, associations were examined for decision‐making preference, decision‐making opportunity, and satisfaction with…”
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Nonsymmorphic chiral symmetry and solitons in the Rice-Mele model by Allen, Rebecca E. J, Gibbons, Holly V, Sherlock, Alex M, Stanfield, Harvey R. M, McCann, Edward

“…Phys. Rev. B 106, 165409 (2022) The Rice-Mele model has two topological and spatially-inversion symmetric phases, namely the Su-Schrieffer-Heeger (SSH) phase…”
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Narcissus bulblet formation in vitro: effects of carbohydrate type and osmolarity of the culture medium by Staikidou, I, Watson, S, Harvey, B.M.R, Selby, C

“…Shoot clump cultures of Narcissus cultivars St. Keverne and Hawera were used to investigate the effects of culture medium carbon supply, type of carbohydrate…”
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The impact of a comprehensive medical benefit cost management program for the city of Birmingham: results at five years by Harvey, M R, Whitmer, R W, Hilyer, J C, Brown, K C

“…Double digit annual increases in the cost of medical benefits represent one of the major financial challenges for many private and public sector employers…”
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