Search Results - "Harvey, Peta J."

Conformational Flexibility Is a Determinant of Permeability for Cyclosporin by Wang, Conan K, Swedberg, Joakim E, Harvey, Peta J, Kaas, Quentin, Craik, David J

“…Several cyclic peptides have been reported to have unexpectedly high membrane permeability. Of these, cyclosporin A is perhaps the most well-known example,…”
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Characterization of Tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties by Vernen, Felicitas, Harvey, Peta J., Dias, Susana, Veiga, Ana Salome, Huang, Yen-Hua, Craik, David J., Lawrence, Nicole, Troeira Henriques, Sónia

“…© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative…”
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Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design by Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Crai, David J., Freissmutha, Michael, Grubera, Christian W.

“…Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide bonds that confer them with exceptional stability. They were…”
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Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist by Luo, Sulan, Zhangsun, Dongting, Harvey, Peta J., Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Li, Xiaodan, Tsetlin, Victor I., (Цетлин), Christensen, Sean, Romero, Haylie K., McIntyre, Melissa, Dowell, Cheryl, Baxter, James C., Elmslie, Keith S., Craik, David J., McIntosh, J. Michael

“…We identified a previously unidentified conotoxin gene fromConus generaliswhose precursor signal sequence has high similarity to the O1-gene conotoxin…”
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Dermatophytic defensin with antiinfective potential by Zhu, Shunyi, Gao, Bin, Harvey, Peta J., Craik, David J.

“…Fungi are a newly emerging source of peptide antibiotics with therapeutic potential. Here, we report 17 new fungal defensin-like peptide (fDLP) genes and the…”
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Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis by Jackson, Mark A., Xie, Jing, Nguyen, Linh T. T., Wang, Xiaohan, Yap, Kuok, Harvey, Peta J., Gilding, Edward K., Craik, David J.

“…Multiple sclerosis (MS) is a debilitating disease that requires prolonged treatment with often severe side effects. One experimental MS therapeutic currently…”
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Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures by Vriens, Kim, Cools, Tanne L, Harvey, Peta J, Craik, David J, Spincemaille, Pieter, Cassiman, David, Braem, Annabel, Vleugels, Jozef, Nibbering, Peter H, Drijfhout, Jan Wouter, De Coninck, Barbara, Cammue, Bruno P A, Thevissen, Karin

“…Plant defensins are small, cysteine-rich peptides with antifungal activity against a broad range of yeast and fungi. In this study we investigated the…”
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Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32 by Kerenga, Bomai K, McKenna, James A, Harvey, Peta J, Quimbar, Pedro, Garcia-Ceron, Donovan, Lay, Fung T, Phan, Thanh Kha, Veneer, Prem K, Vasa, Shaily, Parisi, Kathy, Shafee, Thomas M A, van der Weerden, Nicole L, Hulett, Mark D, Craik, David J, Anderson, Marilyn A, Bleackley, Mark R

“…Pathogenic microbes are developing resistance to established antibiotics, making the development of novel antimicrobial molecules paramount. One major resource…”
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Towards a Sustainable Management of the Spotted-Wing Drosophila: Disclosing the Effects of Two Spider Venom Peptides on Drosophila suzukii by Regalado, Laura, Sario, Sara, Mendes, Rafael J, Valle, Javier, Harvey, Peta J, Teixeira, Cátia, Gomes, Paula, Andreu, David, Santos, Conceição

“…The spotted-wing drosophila ( ) is a polyphagous pest that causes severe damage and economic losses to soft-skinned fruit production. Current control methods…”
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Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold by Gao, Bin, Harvey, Peta J, Craik, David J, Ronjat, Michel, De Waard, Michel, Zhu, Shunyi

“…The ICK (inhibitor cystine knot) defines a large superfamily of polypeptides with high structural stability and functional diversity. Here, we describe a new…”
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Translational Diffusion of Cyclic Peptides Measured Using Pulsed-Field Gradient NMR by Wang, Conan K, Northfield, Susan E, Swedberg, Joakim E, Harvey, Peta J, Mathiowetz, Alan M, Price, David A, Liras, Spiros, Craik, David J

“…Cyclic peptides are increasingly being recognized as valuable templates for drug discovery or design. To facilitate efforts in the structural characterization…”
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Engineering of conotoxins for the treatment of pain by Carstens, Bodil B, Clark, Richard J, Daly, Norelle L, Harvey, Peta J, Kaas, Quentin, Craik, David J

“…The peptides present in the venoms of marine snails are used by the snails to capture prey, but they have also attracted the interest of drug designers because…”
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NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency by Harvey, Peta, Kurniawan, Nyoman, Finol-Urdaneta, Rocio, McArthur, Jeffrey, Van Lysebetten, Dorien, Dash, Thomas, Hill, Justine, Adams, David, Durek, Thomas, Craik, David

“…μ-Conotoxins are potent and highly specific peptide blockers of voltage-gated sodium channels. In this study, the solution structure of μ-conotoxin GIIIC was…”
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The Plant Defensin Ppdef1 Is a Novel Topical Treatment for Onychomycosis by van der Weerden, Nicole L, Parisi, Kathy, McKenna, James A, Hayes, Brigitte M, Harvey, Peta J, Quimbar, Pedro, Wevrett, Sean R, Veneer, Prem K, McCorkelle, Owen, Vasa, Shaily, Guarino, Rosemary, Poon, Simon, Gaspar, Yolanda M, Baker, Michael J, Craik, David J, Turner, Rob B, Brown, Marc B, Bleackley, Mark R, Anderson, Marilyn A

“…Onychomycosis, or fungal nail infection, causes not only pain and discomfort but can also have psychological and social consequences for the patient. Treatment…”
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The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins by Bleackley, Mark R., Dawson, Charlotte S., Payne, Jennifer A.E., Harvey, Peta J., Rosengren, K. Johan, Quimbar, Pedro, Garcia-Ceron, Donovan, Lowe, Rohan, Bulone, Vincent, van der Weerden, Nicole L., Craik, David J., Anderson, Marilyn A.

“…The fungal cell wall is the first point of contact between fungal pathogens and host organisms. It serves as a protective barrier against biotic and abiotic…”
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Histidine-Rich Defensins from the Solanaceae and Brasicaceae Are Antifungal and Metal Binding Proteins by Bleackley, Mark R, Vasa, Shaily, Harvey, Peta J, Shafee, Thomas M.A, da Costa, Tatiana P. Soares, Craik, David J, Lowe, Rohan G.T, Anderson, Marilyn A

“…Plant defensins are best known for their antifungal activity and contribution to the plant immune system. The defining feature of plant defensins is their…”
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Recombinant production of the cyclotide kalata B1 by conditional split inteins by Craik, David J, Yayci, Abdulkadir, Huang, Yen-Hua, Harvey, Peta J

“…This study describes the design, production, and characterization of a novel conditional intein system for the recombinant production of cyclic peptides. The…”
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Accurate de novo design of hyperstable constrained peptides by Bhardwaj, Gaurav, Mulligan, Vikram Khipple, Bahl, Christopher D., Gilmore, Jason M., Harvey, Peta J., Cheneval, Olivier, Buchko, Garry W., Pulavarti, Surya V. S. R. K., Kaas, Quentin, Eletsky, Alexander, Huang, Po-Ssu, Johnsen, William A., Greisen, Per Jr, Rocklin, Gabriel J., Song, Yifan, Linsky, Thomas W., Watkins, Andrew, Rettie, Stephen A., Xu, Xianzhong, Carter, Lauren P., Bonneau, Richard, Olson, James M., Coutsias, Evangelos, Correnti, Colin E., Szyperski, Thomas, Craik, David J., Baker, David

“…Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks generally have shapes that have evolved to fit precisely into…”
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Structure–Activity Relationships of Alanine Scan Mutants αO-Conotoxins GeXIVA[1,2] and GeXIVA[1,4] by Xu, Pan, Zhang, Panpan, Zhu, Xiaopeng, Wu, Yong, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J., Luo, Sulan

“…αO-Conotoxin GeXIVA is a selective α9α10 nicotinic acetylcholine receptor (nAChR) inhibitor displaying two disulfide bonds that can form three isomers. The…”
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Discovery, Characterization, and Engineering of LvIC, an α4/4-Conotoxin That Selectively Blocks Rat α6/α3β4 Nicotinic Acetylcholine Receptors by Zhu, Xiaopeng, Wang, Shuai, Kaas, Quentin, Yu, Jinpeng, Wu, Yong, Harvey, Peta J., Zhangsun, Dongting, Craik, David J., Luo, Sulan

“…α6β4 nicotinic acetylcholine receptors (nAChRs) are expressed in the central and peripheral nervous systems, but their functions are not fully understood,…”
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