Search Results - "Harvey, Natasha L"

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease by Oliver, Guillermo, Kipnis, Jonathan, Randolph, Gwendalyn J., Harvey, Natasha L.

“…Mammals have two specialized vascular circulatory systems: the blood vasculature and the lymphatic vasculature. The lymphatic vasculature is a unidirectional…”
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Regulation of VEGFR Signalling in Lymphatic Vascular Development and Disease: An Update by Secker, Genevieve A., Harvey, Natasha L.

“…The importance of lymphatic vessels in a myriad of human diseases is rapidly gaining recognition; lymphatic vessel dysfunction is a feature of disorders…”
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The lymphatic vasculature: development and role in shaping immunity by Betterman, Kelly L., Harvey, Natasha L.

“…Summary The lymphatic vasculature is an integral component of the immune system. Lymphatic vessels are a key highway via which immune cells are trafficked,…”
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VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels by Secker, Genevieve A., Harvey, Natasha L.

“…Lymphatic vessels are an integral component of the cardiovascular system, serving important roles in fluid homeostasis, lipid absorption, and immune cell…”
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Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program by Frye, Maike, Taddei, Andrea, Dierkes, Cathrin, Martinez-Corral, Ines, Fielden, Matthew, Ortsäter, Henrik, Kazenwadel, Jan, Calado, Dinis P., Ostergaard, Pia, Salminen, Marjo, He, Liqun, Harvey, Natasha L., Kiefer, Friedemann, Mäkinen, Taija

“…Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM)…”
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The Link between Lymphatic Function and Adipose Biology by Harvey, Natasha L.

“…Despite observations of a link between lymphatic vessels and lipids that date as far back as 300, a link between lymphatic vessels and adipose tissue has only…”
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Morphogenesis of the lymphatic vasculature: A focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels by Kazenwadel, Jan, Harvey, Natasha L.

“…Lymphatic vessels serve crucial roles in the regulation of tissue fluid homeostasis, dietary lipid absorption and immune cell trafficking. Defects in lymphatic…”
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Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow by Betterman, Kelly L, Sutton, Drew L, Secker, Genevieve A, Kazenwadel, Jan, Oszmiana, Anna, Lim, Lillian, Miura, Naoyuki, Sorokin, Lydia, Hogan, Benjamin M, Kahn, Mark L, McNeill, Helen, Harvey, Natasha L

“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
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Prox1 expression is negatively regulated by miR-181 in endothelial cells by Kazenwadel, Jan, Michael, Michael Z., Harvey, Natasha L.

“…The specification of arterial, venous, and lymphatic endothelial cell fate is critical during vascular development. Although the homeobox transcription factor,…”
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Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature by Koltowska, Katarzyna, Betterman, Kelly L, Harvey, Natasha L, Hogan, Benjamin M

“…The lymphatic vascular system develops from the pre-existing blood vasculature of the vertebrate embryo. New insights into lymphatic vascular development have…”
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GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
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A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development by Pichol-Thievend, Cathy, Betterman, Kelly L, Liu, Xiaolei, Ma, Wanshu, Skoczylas, Renae, Lesieur, Emmanuelle, Bos, Frank L, Schulte, Dorte, Schulte-Merker, Stefan, Hogan, Benjamin M, Oliver, Guillermo, Harvey, Natasha L, Francois, Mathias

“…Despite the essential role of the lymphatic vasculature in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial…”
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Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity by Johnson, Nicole C, Dillard, Miriam E, Baluk, Peter, McDonald, Donald M, Harvey, Natasha L, Frase, Sharon L, Oliver, Guillermo

“…The activity of the homeobox gene Prox1 is necessary and sufficient for venous blood endothelial cells (BECs) to acquire a lymphatic endothelial cell (LEC)…”
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Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells by Lohraseb, Iman, McCarthy, Peter, Secker, Genevieve, Marchant, Ceilidh, Wu, Jianmin, Ali, Naveid, Kumar, Sharad, Daly, Roger J., Harvey, Natasha L., Kawabe, Hiroshi, Kleifeld, Oded, Wiszniak, Sophie, Schwarz, Quenten

“…The ubiquitin ligase NEDD4 promotes neural crest cell (NCC) survival and stem-cell like properties to regulate craniofacial and peripheral nervous system…”
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Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta by Williamson, Anna E., Liyanage, Sanuri, Hassanshahi, Mohammadhossein, Dona, Malathi S. I., Toledo-Flores, Deborah, Tran, Dang X. A., Dimasi, Catherine, Schwarz, Nisha, Fernando, Sanuja, Salagaras, Thalia, Long, Aaron, Kazenwadel, Jan, Harvey, Natasha L., Drummond, Grant R., Vinh, Antony, Chandrakanthan, Vashe, Misra, Ashish, Neufeld, Zoltan, Tan, Joanne T. M., Martelotto, Luciano, Polo, Jose M., Bonder, Claudine S., Pinto, Alexander R., Sharma, Shiwani, Nicholls, Stephen J., Bursill, Christina A., Psaltis, Peter J.

“…Converging evidence indicates that extra-embryonic yolk sac is the source of both macrophages and endothelial cells in adult mouse tissues. Prevailing views…”
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Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity by Fritzsch, Bernd, Dillard, Miriam, Lavado, Alfonso, Harvey, Natasha L, Jahan, Israt

“…The homeobox gene Prox1 is required for lens, retina, pancreas, liver, and lymphatic vasculature development and is expressed in inner ear supporting cells and…”
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Lymphatic Vessels at the Heart of the Matter by Angeli, Veronique, Harvey, Natasha L.

“…Emergent research in the past decades has brought to light the importance of lymphatic vessels in tissue homeostasis, immunity, metabolism, and inflammation…”
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Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity by Oliver, Guillermo, Harvey, Natasha L, Srinivasan, R Sathish, Dillard, Miriam E, Johnson, Nicole C, Witte, Marlys H, Boyd, Kelli, Sleeman, Mark W

“…Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature…”
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Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development by Coxam, Baptiste, Sabine, Amélie, Bower, Neil I., Smith, Kelly A., Pichol-Thievend, Cathy, Skoczylas, Renae, Astin, Jonathan W., Frampton, Emmanuelle, Jaquet, Muriel, Crosier, Philip S., Parton, Robert G., Harvey, Natasha L., Petrova, Tatiana V., Schulte-Merker, Stefan, Francois, Mathias, Hogan, Benjamin M.

“…Lymphatic vessels arise during development through sprouting of precursor cells from veins, which is regulated by known signaling and transcriptional…”
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Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice by François, Mathias, Short, Kieran, Secker, Genevieve A., Combes, Alexander, Schwarz, Quenten, Davidson, Tara-Lynne, Smyth, Ian, Hong, Young-Kwon, Harvey, Natasha L., Koopman, Peter

“…During lymphangiogenesis in the mammalian embryo, a subset of vascular endothelial cells in the cardinal veins is reprogrammed to adopt a lymphatic endothelial…”
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