Search Results - "Harvey, G. R"

The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones:  Potential Role in Polycyclic Aromatic Hydrocarbon Activation by Palackal, Nisha T, Burczynski, Michael E, Harvey, Ronald G, Penning, Trevor M

“…Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by human epoxide hydrolase (EH) and CYP1A1. Human…”
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Clinical and serological associations with anti‐RNA polymerase antibodies in systemic sclerosis by HARVEY, G. R, BUTTS, S, RANDS, A. L, PATEL, Y, MCHUGH, N. J

“…There are three classes of RNA polymerase enzyme (RNAPs I, II and III). In systemic sclerosis (SSc), three main groups of anti‐RNAP sera have been…”
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New Synthetic Approaches to Polycyclic Aromatic Hydrocarbons and Their Carcinogenic Oxidized Metabolites:  Derivatives of Benzo[s]picene, Benzo[r st]pentaphene, and Dibenzo[b,d ef]chrysene by Zhang, Fang-Jie, Cortez, Cecilia, Harvey, Ronald G

“…A new synthetic approach to polycyclic aromatic compounds is described that entails in the key steps double Suzuki coupling of PAH bisboronic acid derivatives…”
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A blinded, placebo-controlled study of the efficacy of borage seed oil and fish oil in the management of canine atopy by Harvey, R. G.

“…Twenty-one dogs with atopy were entered into a blinded, placebo-controlled study lasting eight weeks. They were randomly divided into three groups and were all…”
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Marine Humic and Fulvic Acids: Their Effects on Remote Sensing of Ocean Chlorophyll by Carder, Kendall L., Steward, Robert G., Harvey, George R., Ortner, Peter B.

“…Marine humic and fulvic acids were concentrated from about 1,400 liters of seawater from the Gulf of Mexico, and specific absorption coefficients were measured…”
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The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro by Littlewood, A J, Russell, J, Harvey, G R, Hughes, D E, Russell, R G, Gowen, M

“…Interleukin 6 (IL-6) probably plays a central role in the acute phase response and in haemopoiesis and may be involved in the control of bone turnover. We have…”
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Metabolism of Benzo[a]pyrene in Human Bronchoalveolar H358 Cells Using Liquid Chromatography–Mass Spectrometry by Jiang, Hao, Gelhaus, Stacy L, Mangal, Dipti, Harvey, Ronald G, Blair, Ian A, Penning, Trevor M

“…Benzo[a]pyrene (B[a]P), a representative polycyclic aromatic hydrocarbon (PAH), is metabolically activated by three enzymatic pathways: by peroxidases (e.g.,…”
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Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts by Shou, M, Harvey, R G, Penning, T M

“…Polycyclic aromatic hydrocarbon (PAH) o-quinones are products of the dihydrodiol dehydrogenase-catalyzed oxidation of trans-dihydrodiols which are proximate…”
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Synthesis of Benzo[s]picene and its Putative Carcinogenic trans-3,4-Dihydrodiol and Fjord Region anti-Diol Epoxide Metabolites by Harvey, R. G, Zhang, J.-T, Luna, E, Pataki, J

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Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism by Smithgall, T E, Harvey, R G, Penning, T M

“…The homogeneous dihydrodiol dehydrogenase of rat liver cytosol catalyzes the NADP-dependent oxidation of polycyclic aromatic trans-dihydrodiols, a reaction…”
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Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene by Amin, S, Desai, D, Dai, W, Harvey, R G, Hecht, S S

“…Diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene were tested for tumorigenicity in…”
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First Examples of Stable Arenium Ions from Large Methylene-Bridged Polycyclic Aromatic Hydrocarbons (PAHs). Directive Effects and Charge Delocalization Mode by Laali, Kenneth K, Okazaki, Takao, Harvey, Ronald G

“…In connection to a growing interest in developing structure/activity trends in nonalternant polyarenes, we report on the generation and NMR studies of the…”
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Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons by Smithgall, T E, Harvey, R G, Penning, T M

“…The homogeneous 3 alpha-hydroxysteroid dehydrogenase (EC 1.1.1.50) of rat liver cytosol is indistinguishable from dihydrodiol dehydrogenase…”
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Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells by Palackal, Nisha T, Lee, Seon Hwa, Harvey, Ronald G, Blair, Ian A, Penning, Trevor M

“…Polycyclic aromatic hydrocarbons (PAH) are environmental pollutants and suspected human lung carcinogens. In patients with non-small cell lung carcinoma,…”
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Spectroscopic characteristics and site I/site II classification of cis and trans benzo[a]pyrene diolepoxide enantiomer-guanosine adducts in oligonucleotides and polynucleotides by Geacintov, N E, Cosman, M, Mao, B, Alfano, A, Ibanez, V, Harvey, R G

“…The highly tumorigenic isomer (+)-7,8-dihydroxy-anti-9, 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-BPDE] and its non-tumorigenic enantiomer…”
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Solution conformation of the (+)-trans-anti-[BPh]dA adduct opposite dT in a DNA duplex: Intercalation of the covalently attached benzo[c]phenanthrene to the 5'-side of the adduct site without disruption of the modified base pair by Cosman, Monique, Fiala, Radovan, Hingerty, Brian E, Laryea, Alfred, Lee, Hongmee, Harvey, Ronald G, Amin, Shantu, Geacintov, Nicholas E, Broyde, Suse, Patel, Dinshaw

“…Benzo[c]phenanthrene diol epoxide can covalently bind to the exocyclic amino group of deoxyadenosine to generate [BPh]dA adducts where the polycyclic aromatic…”
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Anti‐RNA polymerase antibodies in systemic sclerosis (SSc): association with anti‐topoisomerase I antibodies and identification of autoreactive subunits of RNA polymerase II by HARVEY, G. R., RANDS, A. L., McHUGH, N. J.

“…The prevalence of autoantibodies to the three RNA polymerase (RNAP) enzymes in the sera of 249 SSc patients was measured using the technique of…”
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Photoreduction of manganese oxides in seawater and its geochemical and biological implications by Sunda, W. G, Huntsman, S. A, Harvey, G. R

“…The authors have shown that photoreduction of manganese oxides by dissolved organic compounds is important for solubilizing and retaining manganese in the…”
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Mutagenicity of benzo[ a]pyrene–deoxyadenosine adducts in a sequence context derived from the p53 gene by Khalili, Homayoon, Zhang, Fang-Jie, Harvey, Ronald G, Dipple, Anthony

“…Mutations in the human p53 tumor suppressor gene are prominently linked to sporadic cancers in breast, lung and other tissues. Recent research has shown that…”
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Tylosin in the treatment of canine superficial pyoderma by Harvey, R G

“…Thirty dogs with superficial pyoderma were treated orally with tylosin at a dose of 20 mg/kg twice daily for three weeks. Staphylococcus intermedius was…”
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