Search Results - "Harvey, Andrew J."

Performance of M06, M06-2X, and M06-HF Density Functionals for Conformationally Flexible Anionic Clusters: M06 Functionals Perform Better than B3LYP for a Model System with Dispersion and Ionic Hydrogen-Bonding Interactions by Walker, Martin, Harvey, Andrew J. A, Sen, Ananya, Dessent, Caroline E. H

“…We present a comparative assessment of the performance of the M06 suite of density functionals (M06, M06-2X, and M06-HF) against an MP2 benchmark for…”
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Enzymatic characterization of ancestral/group‐IV clade xyloglucan endotransglycosylase/hydrolase enzymes reveals broad substrate specificities by Seven, Merve, Derman, Ü. Cem, Harvey, Andrew J.

“…SUMMARY Xyloglucan endotransglycosylase/hydrolase (XTH) enzymes play important roles in cell wall remodelling. Although previous studies have shown a pathway…”
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Genetics and Transcriptional Profiles of the Cellulose Synthase-Like HvCslF Gene Family in Barley by Burton, Rachel A, Jobling, Stephen A, Harvey, Andrew J, Shirley, Neil J, Mather, Diane E, Bacic, Antony, Fincher, Geoffrey B

“…Cellulose synthase-like CslF genes have been implicated in the biosynthesis of (1,3;1,4)-β-D-glucans, which are major cell wall constituents in grasses and…”
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The CesA Gene Family of Barley. Quantitative Analysis of Transcripts Reveals Two Groups of Co-Expressed Genes by Burton, Rachel A., Shirley, Neil J., Brendon J. King, Harvey, Andrew J., Fincher, Geoffrey B.

“…Sequence data from cDNA and genomic clones, coupled with analyses of expressed sequence tag databases, indicate that the CesA (cellulose synthase) gene family…”
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Substrate specificity and catalytic mechanism of a xyloglucan xyloglucosyl transferase HvXET6 from barley (Hordeum vulgare L.) by Hrmova, Maria, Farkas, Vladimir, Harvey, Andrew J, Lahnstein, Jelle, Wischmann, Bente, Kaewthai, Nomchit, Ezcurra, Inés, Teeri, Tuula T, Fincher, Geoffrey B

“…A family 16 glycoside hydrolase, xyloglucan xyloglucosyl transferase (EC 2.4.1.207), also known as xyloglucan endotransglycosylase (XET), and designated…”
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Molecular modeling of family GH16 glycoside hydrolases: Potential roles for xyloglucan transglucosylases/hydrolases in cell wall modification in the poaceae by Strohmeier, Marco, Hrmova, Maria, Fischer, Markus, Harvey, Andrew J., Fincher, Geoffrey B., Pleiss, Jürgen

“…Family GH16 glycoside hydrolases can be assigned to five subgroups according to their substrate specificities, including xyloglucan…”
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Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3 by Cianci, Julia, Baell, Jonathan B., Flynn, Bernard L., Gable, Robert, W., Mould, Jorgen A., Paul, Dharam, Harvey, Andrew J.

“…Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray…”
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A New Class of Blockers of the Voltage-Gated Potassium Channel Kv1.3 via Modification of the 4- or 7-Position of Khellinone by Harvey, Andrew J, Baell, Jonathan B, Toovey, Nathan, Homerick, Daniel, Wulff, Heike

“…The voltage-gated potassium channel Kv1.3 constitutes an attractive target for the selective suppression of effector memory T cells in autoimmune diseases. We…”
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Evolutionary Dynamics of the Cellulose Synthase Gene Superfamily in Grasses by Schwerdt, Julian G., MacKenzie, Katrin, Wright, Frank, Oehme, Daniel, Wagner, John M., Harvey, Andrew J., Shirley, Neil J., Burton, Rachel A., Schreiber, Miriam, Halpin, Claire, Zimmer, Jochen, Marshall, David F., Waugh, Robbie, Fincher, Geoffrey B.

“…Phylogenetic analyses of cellulose synthase (CesA) and cellulose synthase-like (Csl) families from the cellulose synthase gene superfamily were used to…”
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Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375 by Wang, Xiaohai, Daley, Christopher, Gakhar, Vanita, Lange, Henry S, Vardigan, Joshua D, Pearson, Michelle, Zhou, Xiaoping, Warren, Lee, Miller, Corin O, Belden, Michelle, Harvey, Andrew J, Grishin, Anton A, Coles, Carolyn J, O'Connor, Susan M, Thomson, Fiona, Duffy, Joseph L, Bell, Ian M, Uslaner, Jason M

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Cellulose Synthase-like CslF Genes Mediate the Synthesis of Cell Wall (1,3;1,4)-β-D-Glucans by Burton, Rachel A., Wilson, Sarah M., Hrmova, Maria, Harvey, Andrew J., Shirley, Neil J., Medhurst, Anne, Stone, Bruce A., Newbigin, Edward J., Bacic, Antony, Fincher, Geoffrey B.

“…A characteristic feature of grasses and commercially important cereals is the presence of (1,3;1,4)-β-D-glucans in their cell walls. We have used comparative…”
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Pharmacological Characterization of the Novel and Selective α 7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375 by Wang, Xiaohai, Daley, Christopher, Gakhar, Vanita, Lange, Henry S, Vardigan, Joshua D, Pearson, Michelle, Zhou, Xiaoping, Warren, Lee, Miller, Corin O, Belden, Michelle, Harvey, Andrew J, Grishin, Anton A, Coles, Carolyn J, O'Connor, Susan M, Thomson, Fiona, Duffy, Joseph L, Bell, Ian M, Uslaner, Jason M

“…Treatments for cognitive deficits associated with central nervous system (CNS) disorders such as Alzheimer disease and schizophrenia remain significant unmet…”
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Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs by Harvey, Andrew J, Avery, Thomas D, Schaeffer, Laurent, Joseph, Christophe, Huff, Belinda C, Singh, Rajinder, Morice, Christophe, Giethlen, Bruno, Grishin, Anton A, Coles, Carolyn J, Kolesik, Peter, Wagner, Stéphanie, Andriambeloson, Emile, Huyard, Bertrand, Poiraud, Etienne, Paul, Dharam, O’Connor, Susan M

“…Positive allosteric modulators (PAMs) of α7 nAChRs can have different properties with respect to their effects on channel kinetics. Type I PAMs amplify peak…”
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Customized Gene Expression Microarray Reveals That the Brittle Stem Phenotype fs2 of Barley Is Attributable to a Retroelement in the HvCesA4 Cellulose Synthase Gene by Burton, Rachel A, Ma, Gang, Baumann, Ute, Harvey, Andrew J, Shirley, Neil J, Taylor, Jillian, Pettolino, Filomena, Bacic, Antony, Beatty, Mary, Simmons, Carl R, Dhugga, Kanwarpal S, Rafalski, J. Antoni, Tingey, Scott V, Fincher, Geoffrey B

“…The barley (Hordeum vulgare) brittle stem mutants, fs2, designated X054 and M245, have reduced levels of crystalline cellulose compared with their parental…”
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Rice family GH1 glycoside hydrolases with β- d-glucosidase and β- d-mannosidase activities by Kuntothom, Teerachai, Luang, Sukanya, Harvey, Andrew J., Fincher, Geoffrey B., Opassiri, Rodjana, Hrmova, Maria, Ketudat Cairns, James R.

“…Plant β- d-mannosidases and a rice β- d-glucosidase, Os3BGlu7, with weak β- d-mannosidase activity, cluster together in phylogenetic analysis. To investigate…”
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Azobenzene-Containing, Peptidyl α-Ketoesters as Photobiological Switches of α-Chymotrypsin by Harvey, Andrew J, Abell, Andrew D

“…Three photoswitchable, peptidomimetic inhibitors of α-chymotrypsin have been synthesised. The compounds comprise an azobenzene, an α-ketoester and…”
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Khellinone Derivatives as Blockers of the Voltage-Gated Potassium Channel Kv1.3:  Synthesis and Immunosuppressive Activity by Baell, Jonathan B, Gable, Robert W, Harvey, Andrew J, Toovey, Nathan, Herzog, Tanja, Hänsel, Wolfram, Wulff, Heike

“…The voltage-gated potassium channel Kv1.3 constitutes a promising new target for the treatment of T-cell-mediated autoimmune diseases such as multiple…”
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Comparative modeling of the three-dimensional structures of family 3 glycoside hydrolases by Harvey, Andrew J., Hrmova, Maria, De Gori, Ross, Varghese, Joseph N., Fincher, Geoffrey B.

“…There are approximately 100 known members of the family 3 group of glycoside hydrolases, most of which are classified as β‐glucosidases and originate from…”
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A Customized Gene Expression Microarray Reveals That the Brittle Stem Phenotype fs2 of Barley Is Attributable to a Retroelement in the HvCesA4 Cellulose Synthase Gene1[W][OA] by Burton, Rachel A, Ma, Gang, Baumann, Ute, Harvey, Andrew J, Shirley, Neil J, Taylor, Jillian, Pettolino, Filomena, Bacic, Antony, Beatty, Mary, Simmons, Carl R, Dhugga, Kanwarpal S, Rafalski, J Antoni, Tingey, Scott V, Fincher, Geoffrey B

“…The barley (Hordeum vulgare) brittle stem mutants, fs2, designated X054 and M245, have reduced levels of crystalline cellulose compared with their parental…”
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Biochemical evidence linking a putative callose synthase gene with (1 --> 3)-beta-D-glucan biosynthesis in barley by Li, Jing, Burton, Rachel A, Harvey, Andrew J, Hrmova, Maria, Wardak, Ahmad Z, Stone, Bruce A, Fincher, Geoffrey B

“…A putative barley (1 --> 3)-beta-D-glucan synthase cDNA of 6.1 kb, which is homologous to the yeast FKS gene, was assembled from DNA fragments obtained through…”
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