A survey for neutralizing antibodies to the three types of poliovirus among children in maiduguri, Nigeria

A survey for neutralizing antibodies to the three types of poliovirus among children in maiduguri, Nigeria

The milestone in polio eradication program is to protect effectively children aged 0–5 years against the three serotypes of poliovirus. It became necessary to measure the level of neutralizing antibodies to the three poliovirus types in an endemic State in Nigeria. Neutralizing antibodies to the pol...

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Bibliographic Details
Published in:Journal of medical virology Vol. 84; no. 4; pp. 691 - 696
Main Authors: Baba, M.M., Haruna, B.A., Ogunmola, O., Ambe, J.P., Shidali, N.N., Oderinde, B., Marcello, A., Talle, M.
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-04-2012
Wiley
Wiley Subscription Services, Inc
Subjects:
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Biological and medical sciences
Child, Preschool
children
Female
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Infant
Infectious diseases
Maiduguri
Male
Medical sciences
Microbiology
Miscellaneous
Neutralization Tests
neutralizing antibodies
Nigeria
Poliomyelitis
Poliomyelitis - prevention & control
Poliovirus - immunology
Poliovirus Vaccines - administration & dosage
Poliovirus Vaccines - immunology
Seroepidemiologic Studies
types of poliovirus
Vaccines
Viral diseases
Virology
Nigeria
Nigeria, Maiduguri
Human
Virus
Maiduguri
Picornaviridae
children
neutralizing antibodies
Enterovirus
Poliovirus
Nigeria
Child
Neutralizing antibody
types of poliovirus
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Summary:The milestone in polio eradication program is to protect effectively children aged 0–5 years against the three serotypes of poliovirus. It became necessary to measure the level of neutralizing antibodies to the three poliovirus types in an endemic State in Nigeria. Neutralizing antibodies to the poliovirus types among children aged 0–5 years was estimated using micro neutralization assay. Of 129 children, 99 (76.8%), 95 (73.6%), and 95 (73.6%) had neutralizing antibodies with the geometric mean titer of 42.7, 31.3, and 33.2 for the poliovirus type 1, 2, and 3, respectively. Fifty‐three percent of the children were protected against the three types of poliovirus. Combination of poliovirus types 1 and 2, 1 and 3, and 2 and 3 were neutralized by 62.8, 58.9, and 61.2% of the children studied, respectively. Only poliovirus type 1 induced antibody titres ≥1:1,024. The number of children with neutralizing antibodies after receiving three doses was significantly higher than those who received one or two doses of oral polio vaccine (P ≤ 0.05). However, those who received more than three doses of oral polio vaccine showed no significant difference in their antibody response. The existence of immunity gap poses a risk of re‐emergence of the paralytic poliovirus. The existence of unimmunized and unprotected children along with high birth rate could impede the success of polio vaccination in Nigeria. Elimination of non‐compliance to polio vaccine, promotion of health education and documented evidence of vaccination of each child with the parents may facilitate the success of polio eradication program in Nigeria. J. Med. Virol. 84:691–696, 2012. © 2011 Wiley Periodicals, Inc.
Bibliography:istex:3CD5FB639250ADB7E4AFCDEB60F85B88BDC4724A
ark:/67375/WNG-NF3L5Z6P-2
ArticleID:JMV23228
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.23228