Is Granular Formulation of Lanthanum Carbonate More Effective than Chewable Tablets?

Maintenance dialysis patients at our hospital who had been receiving lanthanum carbonate (LC) chewable tablets were switched to the same dosage of the granules, and the differences in serum phosphorus (P) levels were compared, together with stratifying patients at the baseline characteristics. Compa...

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Bibliographic Details
Published in:	Therapeutic apheresis and dialysis Vol. 18; no. S1; pp. 23 - 27
Main Authors:	Okamoto, Hidekazu, Haruhara, Koutarou, Kamejima, Sahoko, Mafune, Hana, Manabe, Mayumi, Kanzaki, Goh, Mashiko, Hiroshi, Yokoo, Takashi
Format:	Journal Article
Language:	English
Published:	Australia Blackwell Publishing Ltd 01-06-2014
Subjects:	Adult Aged Chemistry, Pharmaceutical Chewable Tablets Female Granules Humans Hyperphosphatemia - drug therapy Lanthanum - administration & dosage Lanthanum - pharmacology Lanthanum Carbonate Male Middle Aged Patients' Baseline Characteristics Phosphorus - blood Renal Dialysis Retrospective Studies Serum Phosphorus Level Tablets Chewable Tablets Granules Lanthanum Carbonate Patients' Baseline Characteristics Serum Phosphorus Level
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Summary:	Maintenance dialysis patients at our hospital who had been receiving lanthanum carbonate (LC) chewable tablets were switched to the same dosage of the granules, and the differences in serum phosphorus (P) levels were compared, together with stratifying patients at the baseline characteristics. Compared to average serum P level of 5.48 mg/dL for 2 months prior to switching, the average level for 2 months after switching was 4.99 mg/dL (P = 0.049). For patients who were under 60, serum P levels were significantly improved after switching (P = 0.016), and for patients who were concomitantly taking many kinds of medications, a correlation to high reductions of serum P level after switching was shown (R = −0.635, P = 0.015). In order to maximize pharmaceutical potential of LC, we think that it is not only necessary to provide patients with how to take the medication, but it is also important to take into consideration the patients' baseline characteristics.
Bibliography:	ark:/67375/WNG-ZRH1GDHH-Z ArticleID:TAP12207 istex:BE3D4F93DABE542ED657E30480E9F81243B6743C ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1744-9979 1744-9987
DOI:	10.1111/1744-9987.12207