Search Results - "Hartz, Anika M. S."

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    Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers by Rempe, Ralf G, Hartz, Anika MS, Bauer, Björn

    “…Matrix metalloproteinases are versatile endopeptidases with many different functions in the body in health and disease. In the brain, matrix metalloproteinases…”
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    Book Review Journal Article
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    P‑gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy by Hartz, Anika M. S, Pekcec, Anton, Soldner, Emma L. B, Zhong, Yu, Schlichtiger, Juli, Bauer, Bjoern

    Published in Molecular pharmaceutics (03-04-2017)
    “…A cure for epilepsy is currently not available, and seizure genesis, seizure recurrence, and resistance to antiseizure drugs remain serious clinical problems…”
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    Journal Article
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    Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy by Miller, David S, Bauer, Björn, Hartz, Anika M S

    Published in Pharmacological reviews (01-06-2008)
    “…Pharmacotherapy of central nervous system (CNS) disorders (e.g., neurodegenerative diseases, epilepsy, brain cancer, and neuro-AIDS) is limited by the…”
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    Journal Article
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    Protecting P-glycoprotein at the blood-brain barrier from degradation in an Alzheimer's disease mouse model by Ding, Yujie, Zhong, Yu, Baldeshwiler, Andrea, Abner, Erin L, Bauer, Björn, Hartz, Anika M S

    Published in Fluids and barriers of the CNS (06-03-2021)
    “…Failure to clear Aβ from the brain is partly responsible for Aβ brain accumulation in Alzheimer's disease (AD). A critical protein for clearing Aβ across the…”
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    Journal Article
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    A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice by Wolf, Andrea, Bauer, Björn, Abner, Erin L, Ashkenazy-Frolinger, Tal, Hartz, Anika M S

    Published in PloS one (25-01-2016)
    “…Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a widely used Alzheimer's disease (AD) mouse model to evaluate treatment…”
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    Journal Article
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    Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling by Bauer, Björn, Hartz, Anika M S, Pekcec, Anton, Toellner, Kathrin, Miller, David S, Potschka, Heidrun

    Published in Molecular pharmacology (01-05-2008)
    “…Increased expression of drug efflux transporters at the blood-brain barrier accompanies epileptic seizures and complicates therapy with antiepileptic drugs…”
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    Journal Article
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    Role of l‑Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin by Akanuma, Shin-ichi, Yamakoshi, Atsuko, Sugouchi, Takeshi, Kubo, Yoshiyuki, Hartz, Anika M. S, Bauer, Björn, Hosoya, Ken-ichi

    Published in Molecular pharmaceutics (04-06-2018)
    “…Gabapentin is an antiseizure drug that is known to also have beneficial effects on the retinal cells. To use gabapentin in retinal pharmacotherapy, it is…”
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    Journal Article
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    Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers by Tang, Fei, Hartz, Anika M S, Bauer, Björn

    Published in Frontiers in neurology (06-07-2017)
    “…Epilepsy is a common neurological disorder that affects over 70 million people worldwide. Despite the recent introduction of new antiseizure drugs (ASDs),…”
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    Journal Article
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    Brain barriers virtual: an interim solution or future opportunity? by Holder, Brianna M, Tolan, Shaina E, Heinrich, Kaleb K, Miller, Kaitlin C, Hudson, Natalie, Nehra, Geetika, Pizzo, Michelle E, Storck, Steffen E, Elmquist, William F, Engelhardt, Britta, Loryan, Irena, Toborek, Michal, Bauer, Bjoern, Hartz, Anika M S, Kim, Brandon J

    Published in Fluids and barriers of the CNS (01-03-2022)
    “…Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field,…”
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    Journal Article
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    In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation by Bauer, Björn, Yang, Xiaodong, Hartz, Anika M S, Olson, Emily R, Zhao, Rong, Kalvass, J Cory, Pollack, Gary M, Miller, David S

    Published in Molecular pharmacology (01-10-2006)
    “…The ATP-driven drug export pump, P-glycoprotein, is a primary gatekeeper of the blood-brain barrier and a major impediment to central nervous system (CNS)…”
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    Journal Article
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    David S. Miller: Scientist, Mentor, Friend-a tribute and thank you by Bauer, Björn, Renfro, J Larry, Karnaky, Jr, Karl J, Masereeuw, Rosalinde, Fricker, Gert, Cannon, Ron E, Hartz, Anika M S

    Published in Fluids and barriers of the CNS (14-09-2020)
    “…David S. Miller was Acting Scientific Director of the Division of Intramural Research at the National Institute of Environmental Health Sciences, National…”
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    Journal Article
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    Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1 by Hartz, Anika M S, Bauer, Björn, Fricker, Gert, Miller, David S

    Published in Molecular pharmacology (01-09-2004)
    “…The ATP-driven xenobiotic transporter P-glycoprotein is a critical element of the blood-brain barrier. To study regulation of P-glycoprotein function, we…”
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    Journal Article
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    New Evidence for P-gp-Mediated Export of Amyloid-β PEPTIDES in Molecular, Blood-Brain Barrier and Neuronal Models by Chai, Amanda B, Hartz, Anika M S, Gao, Xuexin, Yang, Alryel, Callaghan, Richard, Gelissen, Ingrid C

    “…Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer's brain. Though predominantly generated in neurons,…”
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    Journal Article
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    Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy by Rempe, Ralf G, Hartz, Anika M S, Soldner, Emma L B, Sokola, Brent S, Alluri, Satya R, Abner, Erin L, Kryscio, Richard J, Pekcec, Anton, Schlichtiger, Juli, Bauer, Björn

    Published in The Journal of neuroscience (02-05-2018)
    “…The blood-brain barrier is dysfunctional in epilepsy, thereby contributing to seizure genesis and resistance to antiseizure drugs. Previously, several groups…”
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    Journal Article
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    Modulation of p-glycoprotein transport function at the blood-brain barrier by Bauer, Björn, Hartz, Anika M S, Fricker, Gert, Miller, David S

    “…The central nervous system (CNS) effects of many therapeutic drugs are blunted because of restricted entry into the brain. The basis for this poor permeability…”
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    Journal Article
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    Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome by Hoffman, Jared D, Parikh, Ishita, Green, Stefan J, Chlipala, George, Mohney, Robert P, Keaton, Mignon, Bauer, Bjoern, Hartz, Anika M S, Lin, Ai-Ling

    Published in Frontiers in aging neuroscience (25-09-2017)
    “…Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer's disease (AD). However, the contribution of aging…”
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    Journal Article
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    Glioblastoma Standard of Care: Effects on Tumor Evolution and Reverse Translation in Preclinical Models by Rodgers, Louis T, Villano, John L, Hartz, Anika M S, Bauer, Björn

    Published in Cancers (01-08-2024)
    “…Glioblastoma (GBM) presents a significant public health challenge as the deadliest and most common malignant brain tumor in adults. Despite standard-of-care…”
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    Journal Article
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    Inhibition of human microsomal PGE2 synthase‐1 reduces seizure‐induced increases of P‐glycoprotein expression and activity at the blood‐brain barrier by Soldner, Emma L. B., Hartz, Anika M. S., Akanuma, Shin‐Ichi, Pekcec, Anton, Doods, Henri, Kryscio, Richard J., Hosoya, Ken‐Ichi, Bauer, Björn

    Published in The FASEB journal (01-12-2019)
    “…The cause of antiseizure drug (ASD) resistance in epilepsy is poorly understood. Here, we focus on the transporter P‐glycoprotein (P‐gp) that is partly…”
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    Journal Article
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