Search Results - "Hartz, Anika M. S."
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Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers
Published in Journal of Cerebral Blood Flow & Metabolism (01-09-2016)“…Matrix metalloproteinases are versatile endopeptidases with many different functions in the body in health and disease. In the brain, matrix metalloproteinases…”
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P‑gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy
Published in Molecular pharmaceutics (03-04-2017)“…A cure for epilepsy is currently not available, and seizure genesis, seizure recurrence, and resistance to antiseizure drugs remain serious clinical problems…”
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Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy
Published in Pharmacological reviews (01-06-2008)“…Pharmacotherapy of central nervous system (CNS) disorders (e.g., neurodegenerative diseases, epilepsy, brain cancer, and neuro-AIDS) is limited by the…”
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Protecting P-glycoprotein at the blood-brain barrier from degradation in an Alzheimer's disease mouse model
Published in Fluids and barriers of the CNS (06-03-2021)“…Failure to clear Aβ from the brain is partly responsible for Aβ brain accumulation in Alzheimer's disease (AD). A critical protein for clearing Aβ across the…”
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A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice
Published in PloS one (25-01-2016)“…Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a widely used Alzheimer's disease (AD) mouse model to evaluate treatment…”
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Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling
Published in Molecular pharmacology (01-05-2008)“…Increased expression of drug efflux transporters at the blood-brain barrier accompanies epileptic seizures and complicates therapy with antiepileptic drugs…”
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Role of l‑Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin
Published in Molecular pharmaceutics (04-06-2018)“…Gabapentin is an antiseizure drug that is known to also have beneficial effects on the retinal cells. To use gabapentin in retinal pharmacotherapy, it is…”
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Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers
Published in Frontiers in neurology (06-07-2017)“…Epilepsy is a common neurological disorder that affects over 70 million people worldwide. Despite the recent introduction of new antiseizure drugs (ASDs),…”
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Brain barriers virtual: an interim solution or future opportunity?
Published in Fluids and barriers of the CNS (01-03-2022)“…Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field,…”
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In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation
Published in Molecular pharmacology (01-10-2006)“…The ATP-driven drug export pump, P-glycoprotein, is a primary gatekeeper of the blood-brain barrier and a major impediment to central nervous system (CNS)…”
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David S. Miller: Scientist, Mentor, Friend-a tribute and thank you
Published in Fluids and barriers of the CNS (14-09-2020)“…David S. Miller was Acting Scientific Director of the Division of Intramural Research at the National Institute of Environmental Health Sciences, National…”
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Amyloid-β Contributes to Blood―Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy
Published in Stroke (1970) (01-02-2012)“…Cerebral amyloid angiopathy (CAA) is a degenerative disorder characterized by amyloid-β (Aβ) deposition in the blood-brain barrier (BBB). CAA contributes to…”
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Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1
Published in Molecular pharmacology (01-09-2004)“…The ATP-driven xenobiotic transporter P-glycoprotein is a critical element of the blood-brain barrier. To study regulation of P-glycoprotein function, we…”
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New Evidence for P-gp-Mediated Export of Amyloid-β PEPTIDES in Molecular, Blood-Brain Barrier and Neuronal Models
Published in International journal of molecular sciences (29-12-2020)“…Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer's brain. Though predominantly generated in neurons,…”
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Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy
Published in The Journal of neuroscience (02-05-2018)“…The blood-brain barrier is dysfunctional in epilepsy, thereby contributing to seizure genesis and resistance to antiseizure drugs. Previously, several groups…”
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Modulation of p-glycoprotein transport function at the blood-brain barrier
Published in Experimental biology and medicine (Maywood, N.J.) (01-02-2005)“…The central nervous system (CNS) effects of many therapeutic drugs are blunted because of restricted entry into the brain. The basis for this poor permeability…”
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Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome
Published in Frontiers in aging neuroscience (25-09-2017)“…Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer's disease (AD). However, the contribution of aging…”
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Glioblastoma Standard of Care: Effects on Tumor Evolution and Reverse Translation in Preclinical Models
Published in Cancers (01-08-2024)“…Glioblastoma (GBM) presents a significant public health challenge as the deadliest and most common malignant brain tumor in adults. Despite standard-of-care…”
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Inhibition of human microsomal PGE2 synthase‐1 reduces seizure‐induced increases of P‐glycoprotein expression and activity at the blood‐brain barrier
Published in The FASEB journal (01-12-2019)“…The cause of antiseizure drug (ASD) resistance in epilepsy is poorly understood. Here, we focus on the transporter P‐glycoprotein (P‐gp) that is partly…”
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Editorial: Novel approaches to targeting the vasculature and metabolome to prevent brain aging and related diseases
Published in Frontiers in cellular neuroscience (25-10-2024)Get full text
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