Search Results - "Harty, John"

T cell-mediated immunity to malaria by Kurup, Samarchith P., Butler, Noah S., Harty, John T.

“…Immunity to malaria has been linked to the availability and function of helper CD4 + T cells, cytotoxic CD8 + T cells and γδ T cells that can respond to both…”
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Memory CD8+ T cell‐mediated protection against liver‐stage malaria by Hassert, Mariah, Arumugam, Sahaana, Harty, John T.

“…Summary Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan parasite Plasmodium, which is estimated to cause more…”
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Alt-RNAtive vaccines elicit anti-malarial TRM cells by Hassert, Mariah, Harty, John T.

“…Malaria is a vector-borne disease caused by Plasmodium parasites. In an exciting new study, Ganley et al. harness the power of mRNA vaccines to summon…”
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Pathogen-Specific Inflammatory Milieux Tune the Antigen Sensitivity of CD8+ T Cells by Enhancing T Cell Receptor Signaling by Richer, Martin J., Nolz, Jeffrey C., Harty, John T.

“…CD8+ T cells confer host protection through T-cell-receptor (TCR)-mediated recognition of foreign antigens presented by infected cells. Thus, generation of…”
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Tissue resident memory T cells- A new benchmark for the induction of vaccine-induced mucosal immunity by Hassert, Mariah, Harty, John T.

“…Historically, the gold-standard benchmark for vaccine immunogenicity has been the induction of neutralizing antibodies detectable in the serum of peripheral…”
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Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus by Slütter, Bram, Pewe, Lecia L., Kaech, Susan M., Harty, John T.

“…Inducing memory CD8+ T cells specific for conserved antigens from influenza A virus (IAV) is a potential strategy for broadly protective vaccines. Here we show…”
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Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus by Slütter, Bram, Pewe, Lecia L, Kaech, Susan M, Harty, John T

“…Inducing memory CD8(+) T cells specific for conserved antigens from influenza A virus (IAV) is a potential strategy for broadly protective vaccines. Here we…”
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Protective Capacity of Memory CD8 + T Cells Is Dictated by Antigen Exposure History and Nature of the Infection by Nolz, Jeffrey C., Harty, John T.

“…Infection or vaccination confers heightened resistance to pathogen rechallenge because of quantitative and qualitative differences between naive and primary…”
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Shaping and reshaping CD8 + T-cell memory by Harty, John T, Badovinac, Vladimir P

“…Key Points Shortly after infection and/or vaccination, rare, antigen-specific CD8 + T cells encounter mature antigen-expressing dendritic cells (DCs), become…”
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Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection by Schmidt, Megan E, Knudson, Cory J, Hartwig, Stacey M, Pewe, Lecia L, Meyerholz, David K, Langlois, Ryan A, Harty, John T, Varga, Steven M

“…Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8…”
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Differentiation and Persistence of Memory CD8 + T Cells Depend on T Cell Factor 1 by Zhou, Xinyuan, Yu, Shuyang, Zhao, Dong-Mei, Harty, John T., Badovinac, Vladimir P., Xue, Hai-Hui

“…T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the canonical Wnt pathway and is essential for normal T cell development. However,…”
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Keeping T cell memories in mind by Mix, Madison R., Harty, John T.

“…Tissue-resident memory (TRM) T cells embed in the mammalian central nervous system (CNS) to provide long-term immune surveillance. TRM exhibit pleotropic roles…”
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Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites by Schmidt, Nathan W, Butler, Noah S, Badovinac, Vladimir P, Harty, John T

“…Radiation-attenuated Plasmodium sporozoites (RAS) are the only vaccine shown to induce sterilizing protection against malaria in both humans and rodents…”
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Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity by Van Braeckel-Budimir, Natalija, Varga, Steven M., Badovinac, Vladimir P., Harty, John T.

“…Lung-resident primary memory CD8+ T cell populations (Trm) induced by a single influenza infection decline within months, rendering the host susceptible to new…”
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IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo by Starbeck-Miller, Gabriel R, Xue, Hai-Hui, Harty, John T

“…TCR ligation and co-stimulation induce cellular division; however, optimal accumulation of effector CD8 T cells requires direct inflammatory signaling by…”
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Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection by Butler, Noah S, Moebius, Jacqueline, Pewe, Lecia L, Traore, Boubacar, Doumbo, Ogobara K, Tygrett, Lorraine T, Waldschmidt, Thomas J, Crompton, Peter D, Harty, John T

“…Chronically infected mice upregulate expression of inhibitory molecules on exhausted T cells. Harty and colleagues report similar findings in human patients…”
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You Shall Not Pass: Memory CD8 T Cells in Liver-Stage Malaria by Lefebvre, Mitchell N., Harty, John T.

“…Each year over 200 million malaria infections occur, with over 400 000 associated deaths. Vaccines formed with attenuated whole parasites can induce protective…”
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IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking by Nolz, Jeffrey C, Harty, John T

“…Memory and naive CD8+ T cells exhibit distinct trafficking patterns. Specifically, memory but not naive CD8+ T cells are recruited to inflamed tissues in an…”
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Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4 by Kurup, Samarchith P, Obeng-Adjei, Nyamekye, Anthony, Scott M, Traore, Boubacar, Doumbo, Ogobara K, Butler, Noah S, Crompton, Peter D, Harty, John T

“…John Harty and colleagues report that, in mouse models of malaria, regulatory T cells expand, as in humans, and inhibit conventional T cells and germinal…”
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Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria by Drewry, Lisa L., Harty, John T.

“…Malarial disease caused by Plasmodium parasites challenges the mammalian immune system with a delicate balancing act. Robust inflammatory responses are…”
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