Search Results - "Hartwig, John H"

The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling by Grozovsky, Renata, Begonja, Antonija Jurak, Liu, Kaifeng, Visner, Gary, Hartwig, John H, Falet, Hervé, Hoffmeister, Karin M

“…Binding of aged, desialylated platelets to the Ashwell-Morell receptor induces hepatic expression of the cytokine thrombopoietin via JAK2-STAT3 signaling,…”
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Extracellular DNA traps promote thrombosis by Fuchs, Tobias A., Brill, Alexander, Duerschmied, Daniel, Schatzberg, Daphne, Monestier, Marc, Myers, Daniel D., Wrobleski, Shirley K., Wakefield, Thomas W., Hartwig, John H., Wagner, Denisa D.

“…Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and…”
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The filamins: Organizers of cell structure and function by Nakamura, Fumihiko, Stossel, Thomas P., Hartwig, John H.

“…Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in 1975. Thirty five years of FLNa research has revealed its…”
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active biopolymer network controlled by molecular motors by Koenderink, Gijsje H, Dogic, Zvonimir, Nakamura, Fumihiko, Bendix, Poul M, MacKintosh, Frederick C, Hartwig, John H, Stossel, Thomas P, Weitz, David A

“…We describe an active polymer network in which processive molecular motors control network elasticity. This system consists of actin filaments cross-linked by…”
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Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion by Mouneimne, Ghassan, Hansen, Scott D., Selfors, Laura M., Petrak, Lara, Hickey, Michele M., Gallegos, Lisa L., Simpson, Kaylene J., Lim, James, Gertler, Frank B., Hartwig, John H., Mullins, R. Dyche, Brugge, Joan S.

“…Dynamic actin cytoskeletal reorganization is integral to cell motility. Profilins are well-characterized regulators of actin polymerization; however,…”
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Cytoskeletal mechanics of proplatelet maturation and platelet release by Thon, Jonathan N, Montalvo, Alejandro, Patel-Hett, Sunita, Devine, Matthew T, Richardson, Jennifer L, Ehrlicher, Allen, Larson, Mark K, Hoffmeister, Karin, Hartwig, John H, Italiano, Joseph E. Jr

“…Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production…”
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Protein 4.1R-dependent multiprotein complex: New insights into the structural organization of the red blood cell membrane by Salomao, Marcela, Zhang, Xihui, Yang, Yang, Lee, Soohee, Hartwig, John H, Chasis, Joel Anne, Mohandas, Narla, An, Xiuli

“…Protein 4.1R (4.1R) is a multifunctional component of the red cell membrane. It forms a ternary complex with actin and spectrin, which defines the nodal…”
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Microtubule and cortical forces determine platelet size during vascular platelet production by Thon, Jonathan N, Macleod, Hannah, Begonja, Antonija Jurak, Zhu, Jie, Lee, Kun-Chun, Mogilner, Alex, Hartwig, John H., Italiano, Joseph E.

“…Megakaryocytes release large preplatelet intermediates into the sinusoidal blood vessels. Preplatelets convert into barbell-shaped proplatelets in vitro to…”
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Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein by Bender, Markus, Thon, Jonathan N., Ehrlicher, Allen J., Wu, Stephen, Mazutis, Linas, Deschmann, Emoke, Sola-Visner, Martha, Italiano, Joseph E., Hartwig, John H.

“…Bone marrow megakaryocytes produce platelets by extending long cytoplasmic protrusions, designated proplatelets, into sinusoidal blood vessels. Although…”
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Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex by Poulter, Natalie S., Pollitt, Alice Y., Davies, Amy, Malinova, Dessislava, Nash, Gerard B., Hannon, Mike J., Pikramenou, Zoe, Rappoport, Joshua Z., Hartwig, John H., Owen, Dylan M., Thrasher, Adrian J., Watson, Stephen P., Thomas, Steven G.

“…The actin nodule is a novel F-actin structure present in platelets during early spreading. However, only limited detail is known regarding nodule organization…”
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Dual roles for hepatic lectin receptors in the clearance of chilled platelets by Hoffmeister, Karin M, Marth, Jamey D, Hartwig, John H, Josefsson, Emma C, Wandall, Hans H, Rumjantseva, Viktoria, Larson, Göran, Grewal, Prabhjit K, Sørensen, Anne Louise

“…Unlike other types of blood components, refrigeration of platelets leads to their rapid clearance from the circulation after transfusion. Platelets must…”
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Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott–Aldrich syndrome-like platelet defect by Bender, Markus, Stritt, Simon, Nurden, Paquita, van Eeuwijk, Judith M. M., Zieger, Barbara, Kentouche, Karim, Schulze, Harald, Morbach, Henner, Stegner, David, Heinze, Katrin G., Dütting, Sebastian, Gupta, Shuchi, Witke, Walter, Falet, Hervé, Fischer, Alain, Hartwig, John H., Nieswandt, Bernhard

“…Wiskott–Aldrich syndrome (WAS) is caused by mutations in the WAS gene and is characterized by immunodeficiency, eczema and microthrombocytopenia. The molecular…”
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Structural basis of filamin A functions by Nakamura, Fumihiko, Osborn, Teresia M, Hartemink, Christopher A, Hartwig, John H, Stossel, Thomas P

“…Filamin A (FLNa) can effect orthogonal branching of F-actin and bind many cellular constituents. FLNa dimeric subunits have N-terminal spectrin family F-actin…”
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CLEC-2 activates Syk through dimerization by Hughes, Craig E., Pollitt, Alice Y., Mori, Jun, Eble, Johannes A., Tomlinson, Michael G., Hartwig, John H., O'Callaghan, Christopher A., Fütterer, Klaus, Watson, Steve P.

“…The C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins…”
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FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets by Begonja, Antonija Jurak, Pluthero, Fred G., Suphamungmee, Worawit, Giannini, Silvia, Christensen, Hilary, Leung, Richard, Lo, Richard W., Nakamura, Fumihiko, Lehman, William, Plomann, Markus, Hoffmeister, Karin M., Kahr, Walter H.A., Hartwig, John H., Falet, Hervé

“…Bin-Amphiphysin-Rvs (BAR) and Fes-CIP4 homology BAR (F-BAR) proteins generate tubular membrane invaginations reminiscent of the megakaryocyte (MK) demarcation…”
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A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function by Falet, Hervé, Pollitt, Alice Y, Begonja, Antonija Jurak, Weber, Sarah E, Duerschmied, Daniel, Wagner, Denisa D, Watson, Steve P, Hartwig, John H

“…Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX-V to the underlying cytoskeleton in platelets. Because…”
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Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation by Machlus, Kellie R., Wu, Stephen K., Stumpo, Deborah J., Soussou, Thomas S., Paul, David S., Campbell, Robert A., Kalwa, Hermann, Michel, Thomas, Bergmeier, Wolfgang, Weyrich, Andrew S., Blackshear, Perry J., Hartwig, John H., Italiano, Joseph E.

“…Platelets are essential for hemostasis, and thrombocytopenia is a major clinical problem. Megakaryocytes (MKs) generate platelets by extending long processes,…”
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Regulation of Dynamin Oligomerization in Cells: The Role of Dynamin–Actin Interactions and Its GTPase Activity by Gu, Changkyu, Chang, Joann, Shchedrina, Valentina A., Pham, Vincent A., Hartwig, John H., Suphamungmee, Worawit, Lehman, William, Hyman, Bradley T., Bacskai, Brian J., Sever, Sanja

“…Dynamin is a 96‐kDa protein that has multiple oligomerization states that influence its GTPase activity. A number of different dynamin effectors, including…”
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RefilinB (FAM101B) targets FilaminA to organize perinuclear actin networks and regulates nuclear shape by Gay, Olivia, Gilquin, Benoît, Nakamura, Fumihiko, Jenkins, Zandra A, McCartney, Rosannah, Krakow, Deborah, Deshiere, Alexandre, Assard, Nicole, Hartwig, John H, Robertson, Stephen P, Baudier, Jacques

“…The intracellular localization and shape of the nucleus plays a central role in cellular and developmental processes. In fibroblasts, nuclear movement and…”
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Disease-associated mutant α-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity by Weins, Astrid, Schlondorff, Johannes S, Nakamura, Fumihiko, Denker, Bradley M, Hartwig, John H, Stossel, Thomas P, Pollak, Martin R

“…α-Actinin-4 is a widely expressed protein that employs an actin-binding site with two calponin homology domains to crosslink actin filaments (F-actin) in a…”
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