Search Results - "Hartung, Helge"

Acquired Aplastic Anemia in Children by Hartung, Helge D., MD, Olson, Timothy S., MD, PhD, Bessler, Monica, MD, PhD

“…This article provides a practice-based and concise review of the etiology, diagnosis, and management of acquired aplastic anemia in children. Bone marrow…”
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Biexponential R2 relaxometry for estimation of liver iron concentration in children: A better fit for high liver iron states by Barrera, Christian A., Khrichenko, Dmitry, Serai, Suraj D., Hartung, Helge D., Biko, David M., Otero, Hansel J.

“…Background R2* relaxometry's capacity to calculate liver iron concentration (LIC) is limited in patients with severe overload. Hemosiderin increases in these…”
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Protocol optimization for cardiac and liver iron content assessment using MRI: What sequence should I use? by Barrera, Christian A., Otero, Hansel J., Hartung, Helge D., Biko, David M., Serai, Suraj D.

“…To determine the optimal MRI protocol and sequences for liver and cardiac iron estimation in children. We evaluated patients ≤18 years with cardiac and liver…”
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Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer by Estécio, Marcos R H, Gallegos, Juan, Vallot, Céline, Castoro, Ryan J, Chung, Woonbok, Maegawa, Shinji, Oki, Yasuhiro, Kondo, Yutaka, Jelinek, Jaroslav, Shen, Lanlan, Hartung, Helge, Aplan, Peter D, Czerniak, Bogdan A, Liang, Shoudan, Issa, Jean-Pierre J

“…Epigenetic silencing plays an important role in cancer development. An attractive hypothesis is that local DNA features may participate in differential…”
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Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease by Ipe, Tina S, Wilkes, Jennifer J, Hartung, Helge D, Westhoff, Connie M, Chou, Stella T, Friedman, David F

“…A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation…”
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Dehydrated hereditary stomatocytosis masquerading as MDS by Paessler, Michele, Hartung, Helge

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Pancytopenia in a patient with methylmalonic acidemia by MacFarland, Suzanne, Hartung, Helge

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SPRINTing to Innovation: Children’s Hospital of Philadelphia’s Strategic Approach to Discovering Its Untapped Innovation Potential by Hunter, Ryan Brandon, Winston, Flaura K., Dehel, Paul, Oh, Kelsey, Nicklas, Joshua, Hartung, Helge

“…PROBLEM:There is a clear and urgent need for health care innovation in the United States. Hospital employees routinely recognize pain points that affect care…”
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L‐leucine improves anemia and growth in patients with transfusion‐dependent Diamond‐Blackfan anemia: Results from a multicenter pilot phase I/II study from the Diamond‐Blackfan Anemia Registry by Vlachos, Adrianna, Atsidaftos, Evangelia, Lababidi, Mohammad Lutfi, Muir, Ellen, Rogers, Zora R., Alhushki, Waseem, Bernstein, Jonathan, Glader, Bertil, Gruner, Barbara, Hartung, Helge, Knoll, Christine, Loew, Thomas, Nalepa, Grzegorz, Narla, Anupama, Panigrahi, Arun R., Sieff, Colin A., Walkovich, Kelly, Farrar, Jason E., Lipton, Jeffrey M.

“…Background Diamond‐Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized by anemia, short stature, congenital anomalies, and cancer…”
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Effects of the COVID-19 Pandemic on Caregivers of Young Children with Sickle Cell Disease Enrolled in the Engage-HU Trial by Hood, Anna M, Hildenbrand, Aimee K, Rebitski, Joanna, Stallworth, Jasmine, Johnson, Yolanda, Gomes, Stacey, Whitacre, Catharine, Mara, Constance A, Shook, Lisa M, Quinn, Charles T., Raphael, Jean L., Yates, Amber M, Badawy, Sherif M., Thompson, Alexis A., Smith-Whitley, Kim, Hartung, Helge, King, Allison A., Creary, Susan E, Bhasin, Neha, Reader, Steven K, Meier, Emily R., Tubman, Venee N., Crosby, Lori E.

“…Background: Hydroxyurea (HU) is the primary medication used to prevent the significant medical and neurologic morbidities of pediatric sickle cell disease…”
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Metformin for Treatment of Cytopenias in Children and Young Adults with Fanconi Anemia by Pollard, Jessica A., Furutani, Elissa M., Liu, Shanshan, Esrick, Erica B., Cohen, Laurie, Bledsoe, Jacob, Lu, Kun, Ramirez, Maria Jose, Surrallés, Jordi, Malsch, Maggie, Kuniholm, Ashley, Galvin, Ashley, Armant, Myriam, Kim, Annette S., Ballotti, Kaitlyn, Moreau, Lisa, Zhou, Yu, Babushok, Daria V., Boulad, Farid, Carroll, Clinton, Hartung, Helge, Hont, Amy, Nakano, Taizo A., Olson, Timothy S., Sze, Sei-Gyung K., Thompson, Alexis A, Wlodarski, Marcin W., Libermann, Towia A, D'Andrea, Alan D., Grompe, Markus, Weller, Edie A., Shimamura, Akiko

“…Fanconi anemia (FA), a genetic disorder affecting DNA repair, is characterized by bone marrow failure and cancer susceptibility. In FA mouse models, metformin…”
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Red blood cell alloimmunization in transfused patients with bone marrow failure syndromes by Cohen, Devin, Hartung, Helge, Evans, Perry, Friedman, David F., Chou, Stella T.

“…BACKGROUND Red blood cell (RBC) alloimmunization is a concern for patients who receive multiple or chronic transfusions. Alloimmunization prevalence in…”
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Disrupted Lymphocyte Homeostasis in Hepatitis-Associated Acquired Aplastic Anemia Is Associated with Very Low Telomere Lengths by Grignon, Anne-Laure, Babushok, Daria V., Yimei, Li, Hartung, Helge, Lam, Ho-Sun, Bessler, Monica, Olson, Timothy S.

“…Acquired aplastic anemia (AA) is a hematologic disorder characterized by low blood counts and a hypocellular bone marrow, caused by autoimmune destruction of…”
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Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia by Babushok, Daria V, Perdigones, Nieves, Perin, Juan C, Olson, Timothy S, Ye, Wenda, Roth, Jacquelyn J, Lind, Curt, Cattier, Carine, Li, Yimei, Hartung, Helge, Paessler, Michele E, Frank, Dale M, Xie, Hongbo M, Cross, Shanna, Cockroft, Joshua D, Podsakoff, Gregory M, Monos, Dimitrios, Biegel, Jaclyn A, Mason, Philip J, Bessler, Monica

“…Acquired aplastic anemia (aAA) is a nonmalignant disease caused by autoimmune destruction of early hematopoietic cells. Clonal hematopoiesis is a late…”
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A Standardized Clinical Pathway to Decrease Hospital Admissions Among Febrile Children With Sickle Cell Disease by Ellison, Angela M, Smith Whitley, Kim, Kittick, Marlena, Schast, Aileen, Norris, Cynthia, Hartung, Helge, McKnight, Therese, Coyne, Erin, Lavelle, Jane

“…Recurrent hospital admissions for patients with sickle cell disease (SCD) are costly and contribute to a low quality of life for patients. We implemented a…”
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Leucine for the Treatment of Transfusion Dependence in Patients with Diamond Blackfan Anemia by Vlachos, Adrianna, Atsidaftos, Evangelia, Muir, Ellen, Rogers, Zora R., Lababidi, Mohammad Lufti, Alhushki, Waseem, Farrar, Jason E., Glader, Bertil, Gruner, Barbara, Hartung, Helge, Knoll, Christine M., Nalepa, Grzegorz, Narla, Anupama, Panigrahi, Arun Ranjan, Sieff, Colin A., Walkovich, Kelly J., Lipton, Jeffrey M

“…▪ Diamond Blackfan anemia (DBA) is a rare, inherited bone marrow failure syndrome characterized by anemia, congenital anomalies and a predisposition to cancer…”
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Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation by SLAPE, Christopher, HARTUNG, Helge, LIN, Ying-Wei, BIES, Juraj, WOLFF, Linda, APIAN, Peter D

“…The t(2;11)(q31;p15) chromosomal translocation results in a fusion between the NUP98 and HOXD13 genes and has been observed in patients with myelodysplastic…”
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Disrupted lymphocyte homeostasis in hepatitis‐associated acquired aplastic anemia is associated with short telomeres by Babushok, Daria V., Grignon, Anne‐Laure, Li, Yimei, Atienza, Jamie, Xie, Hongbo M., Lam, Ho‐Sun, Hartung, Helge, Bessler, Monica, Olson, Timothy S.

“…Hepatitis‐associated aplastic anemia (HAA) is a variant of acquired aplastic anemia (AA) in which immune‐mediated bone marrow failure (BMF) develops following…”
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Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart by Hartung, Helge, Feldman, Benjamin, Lovec, Heike, Coulier, Francois, Birnbaum, Daniel, Goldfarb, Mitchell

“…The molecular cloning of cDNAs encoding murine fibroblast growth factor-13 (FGF-13/FHF-2) and three isoforms of murine FGF-12 (FHF-1) is described. Like their…”
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Metformin for treatment of cytopenias in children and young adults with Fanconi anemia by Pollard, Jessica A, Furutani, Elissa, Liu, Shanshan, Esrick, Erica, Cohen, Laurie E, Bledsoe, Jacob, Liu, Chih-Wei, Lu, Kun, de Haro, Maria Jose Ramirez, Surrallés, Jordi, Malsch, Maggie, Kuniholm, Ashley, Galvin, Ashley, Armant, Myriam, Kim, Annette S, Ballotti, Kaitlyn, Moreau, Lisa, Zhou, Yu, Babushok, Daria, Boulad, Farid, Carroll, Clint, Hartung, Helge, Hont, Amy, Nakano, Taizo, Olson, Tim, Sze, Sei-Gyung, Thompson, Alexis A, Wlodarski, Marcin W, Gu, Xuesong, Libermann, Towia A, D'Andrea, Alan, Grompe, Markus, Weller, Edie, Shimamura, Akiko

“…Fanconi anemia (FA), a genetic DNA repair disorder characterized by marrow failure and cancer susceptibility. In FA mice, metformin improves blood counts and…”
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