Search Results - "Hartrodt, B"

renal type H⁺/peptide symporter PEPT2: structure-affinity relationships by Biegel, A, Knütter, I, Hartrodt, B, Gebauer, S, Theis, S, Luckner, P, Kottra, G, Rastetter, M, Zebisch, K, Thondorf, I, Daniel, H, Neubert, K, Brandsch, M

“…The H⁺/peptide cotransporter PEPT2 is expressed in a variety of organs including kidney, lung, brain, mammary gland, and eye. PEPT2 substrates are di- and…”
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A Novel Inhibitor of the Mammalian Peptide Transporter PEPT1 by Knütter, Ilka, Theis, Stephan, Hartrodt, Bianka, Born, Ilona, Brandsch, Matthias, Daniel, Hannelore, Neubert, Klaus

“…This study was initiated to develop inhibitors of the intestinal H+/peptide symporter. We provide evidence that the dipeptide derivative Lys[Z(NO2)]-Pro is an…”
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Analogues of arginine vasopressin modified in the N-terminal part of the molecule with enantiomers of N-methylphenylalanine by Kowalczyk, W., Derdowska, I., Dawidowska, O., Prahl, A., Hartrodt, B., Neubert, K., Slaninová, J., Lammek, B.

“…:  Four new analogues of arginine vasopressin (AVP) substituted in positions 2 and 3 with all possible combinations of enantiomers of N‐methylphenylalanine…”
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High-performance liquid chromatographic separation of cis-trans isomers of proline-containing peptides. II. Fractionation in different cyclodextrin systems by Friebe, S, Hartrodt, B, Neubert, K, Krauss, G J

“…beta-Cyclodextrin-bonded silica is demonstrated to be a suitable stationary phase for high-performance liquid chromatography of conformational isomers of…”
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Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV? by Rahfeld, J, Schierhorn, M, Hartrodt, B, Neubert, K, Heins, J

“…Dipeptidyl peptidase IV preferably hydrolyzes peptides and proteins with a penultimate proline residue. Umezawa and co-workers (Umezawa et al. (1984) J…”
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Three-Dimensional Quantitative Structure−Activity Relationship Analyses of β-Lactam Antibiotics and Tripeptides as Substrates of the Mammalian H+/Peptide Cotransporter PEPT1 by Biegel, Annegret, Gebauer, Sabine, Hartrodt, Bianka, Brandsch, Matthias, Neubert, Klaus, Thondorf, Iris

“…The utilization of the membrane transport protein PEPT1 as a drug delivery system is a promising strategy to enhance the oral bioavailability of drugs. Since…”
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New analogues of bradykinin containing a conformationally restricted dipeptide fragment in their molecules by Derdowska, I., Prahl, A., Lammek, B., Neubert, K., Hartrodt, B., Kania, A., Dobrowolski, D., Malhem, S., Trzeciak, H.I., Wierzbad, T.

“…: The present paper describes the synthesis and some pharmacological properties of two new bradykinin analogues containing the ethylene‐bridged dipeptide…”
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Three-Dimensional Quantitative Structure−Activity Relationship Analyses of Peptide Substrates of the Mammalian H+/Peptide Cotransporter PEPT1 by Gebauer, Sabine, Knütter, Ilka, Hartrodt, Bianka, Brandsch, Matthias, Neubert, Klaus, Thondorf, Iris

“…The utilization of the carrier protein PEPT1 for the absorption of peptidomimetic drug molecules is a promising strategy for oral drug administration and…”
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Conformational analysis of the tetrapeptide Pro-D-Phe-Pro-Gly in aqueous solution by Hübner, D, Hartrodt, B, Kleinpeter, E, Ströhl, D, Brandt, W, Schinke, H, Wahab, M, Fischer, G

“…Conformational investigations of the tetrapeptide Pro-D-Phe-Pro-Gly in water solution were carried out by 1H and 13C NMR spectroscopy. The internal proline…”
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On the blood-brain barrier to peptides: [3H]beta-casomorphin-5 uptake by eighteen brain regions in vivo by Ermisch, A, Rühle, H J, Neubert, K, Hartrodt, B, Landgraf, R

“…After intracarotid injection of [3H]beta-casomorphin-5 (beta CM5) in rats, the accumulation of radioactivity was determined in 18 brain regions and the…”
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Analysis of the transport properties of side chain modified dipeptides at the mammalian peptide transporter PEPT1 by Knütter, Ilka, Hartrodt, Bianka, Theis, Stephan, Foltz, Martin, Rastetter, Matthias, Daniel, Hannelore, Neubert, Klaus, Brandsch, Matthias

“…This study was initiated to examine systematically the effect of side chain modifications at dipeptides on their transport via PEPT1. We synthesized a series…”
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Conformational analysis of morphiceptin by NMR spectroscopy by Castiglione-Morelli, M A, Hartrodt, B, Neubert, K, Temussi, P A, Trivellone, E

“…Three exorphins, beta-casomorphin-5, morphiceptin and its D-Pro4 analog, were studied in DMSO by means of 1H and 13C NMR spectroscopy, with the aim of…”
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Synthesis and characterization of a new and radiolabeled high-affinity substrate for H⁺/peptide cotransporters by Knütter, Ilka, Hartrodt, Bianka, Tóth, Géza, Keresztes, Attila, Kottra, Gabor, Mrestani-Klaus, Carmen, Born, Ilona, Daniel, Hannelore, Neubert, Klaus, Brandsch, Matthias

“…In this study we described the design, rational synthesis and functional characterization of a novel radiolabeled hydrolysis-resistant high-affinity substrate…”
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Defining minimal structural features in substrates of the H(+)/peptide cotransporter PEPT2 using novel amino acid and dipeptide derivatives by Theis, Stephan, Hartrodt, Bianka, Kottra, Gabor, Neubert, Klaus, Daniel, Hannelore

“…The peptide transporter PEPT2, expressed in a variety of tissues, including kidney, lung, and the central nervous system, mediates the uphill transport of di-…”
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Synthesis and Characterization of High Affinity Inhibitors of the H+/Peptide Transporter PEPT2 by Theis, Stephan, Knütter, Ilka, Hartrodt, Bianka, Brandsch, Matthias, Kottra, Gabor, Neubert, Klaus, Daniel, Hannelore

“…In this study, we describe the rational synthesis and functional analysis of novel high affinity inhibitors for the mammalian peptide transporter PEPT2…”
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The renal type H super(+)/peptide symporter PEPT2: structure-affinity relationships by Biegel, A, Knuetter, I, Hartrodt, B, Gebauer, S, Theis, S, Luckner, P, Kottra, G, Rastetter, M, Zebisch, K, Thondorf, I, Daniel, H, Neubert, K, Brandsch, M

“…The H super(+)/peptide cotransporter PEPT2 is expressed in a variety of organs including kidney, lung, brain, mammary gland, and eye. PEPT2 substrates are di-…”
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The influence of 1-aminocyclopentane-1-carboxylic acid at position 2 or 3 of AVP and its analogues on their pharmacological properties by Kowalczyk, Wioleta, Prahl, Adam, Dawidowska, Olga, Derdowska, Izabela, Sobolewski, Dariusz, Hartrodt, Bianca, Neubert, Klaus, Slaninová, Jiřina, Lammek, Bernard

“…This study describes the synthesis and some pharmacological properties of eight new analogues of arginine vasopressin (AVP) substituted at position 2 or 3 with…”
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Spectroscopic analysis of [Trp3]-beta-casomorphin analogs. Comparative structure conformation-activity studies by Epps, D E, Havel, H A, Sawyer, T K, Staples, D J, Chung, N N, Schiller, P W, Hartrodt, B, Barth, A

“…A series of [3-tryptophan]-beta-casomorphin-5([Trp3]-beta-CM-5) analogs were investigated by circular dichroism (CD) and fluorescence spectroscopy to explore…”
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Synthesis and Characterization of High Affinity Inhibitors of the H super(+)/Peptide Transporter PEPT2 by Theis, S, Knuetter, I, Hartrodt, B, Brandsch, M, Kottra, G, Neubert, K, Daniel, H

“…In this study, we describe the rational synthesis and functional analysis of novel high affinity inhibitors for the mammalian peptide transporter PEPT2…”
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Tyr‐c[D‐Orn‐Tyr(Bzl)‐Pro‐Gly]: a novel antiproliferative acting somatostatin receptor agonist with μ‐opioid receptor‐sensitizing properties by Stirnweiss, Jörg, Hartrodt, Bianka, Greksch, Gisela, Stürzebecher, Uta, Böhmer, Frank‐D, Neubert, Klaus, Liebmann, Claus

“…Here, we introduce a β‐casomorphin‐5‐derived cyclic pentapeptide, cCD‐2 (Tyr‐cyclo[D‐Orn‐Tyr(Bzl)‐Pro‐Gly]), which inhibits the cell growth of a variety of…”
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