Search Results - "Harton, Jonathan A."

The ASC Speck and NLRP3 Inflammasome Function Are Spatially and Temporally Distinct by Nagar, Abhinit, Rahman, Tabassum, Harton, Jonathan A

“…Although considered the ternary inflammasome structure, whether the singular, perinuclear NLRP3:ASC speck is synonymous with the NLRP3 inflammasome is unclear…”
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Inflammasome and Caspase-1 Activity Characterization and Evaluation: An Imaging Flow Cytometer-Based Detection and Assessment of Inflammasome Specks and Caspase-1 Activation by Nagar, Abhinit, DeMarco, Richard A, Harton, Jonathan A

“…Inflammasome dysregulation is a hallmark of various inflammatory diseases. Evaluating inflammasome-associated structures (ASC specks) and caspase-1 activity by…”
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NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features by Rahman, Tabassum, Nagar, Abhinit, Duffy, Ellen B, Okuda, Kendi, Silverman, Neal, Harton, Jonathan A

“…The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3…”
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Pyrin- and CARD-only Proteins as Regulators of NLR Functions by Le, Hongnga T, Harton, Jonathan A

“…Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo domain…”
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Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia by Periasamy, Sivakumar, Le, Hongnga T, Duffy, Ellen B, Chin, Heather, Harton, Jonathan A

“…Francisella tularensis (Ft) causes a frequently fatal, acute necrotic pneumonia in humans and animals. Following lethal Ft infection in mice, infiltration of…”
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An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia by Periasamy, Sivakumar, Avram, Dorina, McCabe, Amanda, MacNamara, Katherine C, Sellati, Timothy J, Harton, Jonathan A

“…Inhalation of Francisella tularensis (Ft) causes acute and fatal pneumonia. The lung cytokine milieu favors exponential Ft replication, but the mechanisms…”
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Repression of Inflammasome by Francisella tularensis during Early Stages of Infection by Dotson, Rachel J., Rabadi, Seham M., Westcott, Elizabeth L., Bradley, Stephen, Catlett, Sally V., Banik, Sukalyani, Harton, Jonathan A., Bakshi, Chandra Shekhar, Malik, Meenakshi

“…Francisella tularensis is an important human pathogen responsible for causing tularemia. F. tularensis has long been developed as a biological weapon and is…”
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Pyrin-only protein 2 limits inflammation but improves protection against bacteria by Periasamy, Sivakumar, Porter, Kristen A., Atianand, Maninjay K., T. Le, Hongnga, Earley, Sarah, Duffy, Ellen B., Haller, Matthew C., Chin, Heather, Harton, Jonathan A.

“…Pyrin domain-only proteins (POPs) are recently evolved, primate-specific proteins demonstrated in vitro as negative regulators of inflammatory responses…”
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Differential Transmembrane Domain GXXXG Motif Pairing Impacts Major Histocompatibility Complex (MHC) Class II Structure by Dixon, Ann M., Drake, Lisa, Hughes, Kelly T., Sargent, Elizabeth, Hunt, Danielle, Harton, Jonathan A., Drake, James R.

“…Major histocompatibility complex (MHC) class II molecules exhibit conformational heterogeneity, which influences their ability to stimulate CD4 T cells and…”
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Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains by Harton, Jonathan A, Linhoff, Michael W, Zhang, Jinghua, Ting, Jenny P.-Y

“…Large mammalian proteins containing a nucleotide-binding domain (NBD) and C-terminal leucine-rich repeats (LRR) similar in structure to plant disease…”
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Identification of a Novel Francisella tularensis Factor Required for Intramacrophage Survival and Subversion of Innate Immune Response by Mahawar, Manish, Atianand, Maninjay K., Dotson, Rachel J., Mora, Vanessa, Rabadi, Seham M., Metzger, Dennis W., Huntley, Jason F., Harton, Jonathan A., Malik, Meenakshi, Bakshi, Chandra Shekhar

“…Background: The mechanism of immune suppression caused by Francisella tularensis SchuS4 strain, a category A agent, are yet unknown. Results:FTL_0325/FTT0831c…”
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Francisella tularensis elicits IL-10 via a PGE₂-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation by Hunt, Danielle, Wilson, Justin E, Weih, Karis A, Ishido, Satoshi, Harton, Jonathan A, Roche, Paul A, Drake, James R

“…Francisella tularensis is a bacterial pathogen that uses host-derived PGE₂ to subvert the host's adaptive immune responses in multiple ways…”
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Flow Imaging of the Inflammasome: Evaluating ASC Speck Characteristics and Caspase-1 Activity by Nagar, Abhinit, Harton, Jonathan A

“…Examining inflammasome-associated speck structures is one of the most preferred and easiest ways to evaluate inflammasome activation. Microscopy-based…”
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Recent evolution of the NF-κB and inflammasome regulating protein POP2 in primates by Atianand, Maninjay K, Fuchs, Travis, Harton, Jonathan A

“…Pyrin-only protein 2 (POP2) is a small human protein comprised solely of a pyrin domain that inhibits NF-κB p65/RelA and blocks the formation of functional…”
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Class II MHC cytoplasmic domain-mediated signaling in B cells: A tail of two signals by Harton, Jonathan A.

“…In addition to their role in antigen presentation, class II MHC molecules also transmit signals to B lymphocytes. Class II MHC-mediated signals initiate a…”
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Interleukin 1α (IL-1α) Promotes Pathogenic Immature Myeloid Cells and IL-1β Favors Protective Mature Myeloid Cells During Acute Lung Infection by Periasamy, Sivakumar, Harton, Jonathan A

“…Abstract Bacterial pneumonia is a common risk factor for acute lung injury and sepsis-mediated death, but the mechanisms underlying the overt inflammation and…”
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Class II transactivator (CIITA) enhances cytoplasmic processing of HIV-1 Pr55Gag by Porter, Kristen A, Kelley, Lauren N, George, Annette, Harton, Jonathan A, Duus, Karen M

“…The Pr55(gag) (Gag) polyprotein of HIV serves as a scaffold for virion assembly and is thus essential for progeny virion budding and maturation. Gag localizes…”
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The NLR Gene Family: A Standard Nomenclature by Ting, Jenny P.-Y., Lovering, Ruth C., Alnemri, Emad S., Bertin, John, Boss, Jeremy M., Davis, Beckley K., Flavell, Richard A., Girardin, Stephen E., Godzik, Adam, Harton, Jonathan A., Hoffman, Hal M., Hugot, Jean-Pierre, Inohara, Naohiro, MacKenzie, Alex, Maltais, Lois J., Nunez, Gabriel, Ogura, Yasunori, Otten, Luc A., Philpott, Dana, Reed, John C., Reith, Walter, Schreiber, Stefan, Steimle, Viktor, Ward, Peter A.

“…[...]we propose a standardized nomenclature, NLR, which stands for the nucleotide-binding domain and leucine-rich repeat containing gene family…”
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NLRP3 moonlights in TH2 polarization by Ting, Jenny P Y, Harton, Jonathan A

“…As the cytosolic guardian for many microbial and sterile inflammatory insults, NLRP3 is best appreciated for its innate immunological role mediating…”
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GTP-dependent Recruitment of CIITA to the Class II Major Histocompatibility Complex Promoter by Bewry, Nadine N., Bolick, Sophia C.E., Wright, Kenneth L., Harton, Jonathan A.

“…We previously established that the class II transactivator CIITA binds GTP and disruption of the GTP binding ability of CIITA results in increased cytoplasmic…”
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