Search Results - "Hartmann, Hannelore"

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment by Guo, Qiang, Lehmer, Carina, Martínez-Sánchez, Antonio, Rudack, Till, Beck, Florian, Hartmann, Hannelore, Pérez-Berlanga, Manuela, Frottin, Frédéric, Hipp, Mark S., Hartl, F. Ulrich, Edbauer, Dieter, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of many neurodegenerative diseases. Here, we address the elusive link…”
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Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity by Hartmann, Hannelore, Hornburg, Daniel, Czuppa, Mareike, Bader, Jakob, Michaelsen, Meike, Farny, Daniel, Arzberger, Thomas, Mann, Matthias, Meissner, Felix, Edbauer, Dieter

“…Frontotemporal dementia and amyotrophic lateral sclerosis patients with mutation show cytoplasmic poly-GR and poly-PR aggregates. Short poly-(Gly-Arg) and…”
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TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons by Schwenk, Benjamin M, Hartmann, Hannelore, Serdaroglu, Alperen, Schludi, Martin H, Hornburg, Daniel, Meissner, Felix, Orozco, Denise, Colombo, Alessio, Tahirovic, Sabina, Michaelsen, Meike, Schreiber, Franziska, Haupt, Simone, Peitz, Michael, Brüstle, Oliver, Küpper, Clemens, Klopstock, Thomas, Otto, Markus, Ludolph, Albert C, Arzberger, Thomas, Kuhn, Peer-Hendrik, Edbauer, Dieter

“…Nuclear clearance of TDP‐43 into cytoplasmic aggregates is a key driver of neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar…”
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Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS by Suárez-Calvet, Marc, Neumann, Manuela, Arzberger, Thomas, Abou-Ajram, Claudia, Funk, Eva, Hartmann, Hannelore, Edbauer, Dieter, Kremmer, Elisabeth, Göbl, Christoph, Resch, Moritz, Bourgeois, Benjamin, Madl, Tobias, Reber, Stefan, Jutzi, Daniel, Ruepp, Marc-David, Mackenzie, Ian R. A., Ansorge, Olaf, Dormann, Dorothee, Haass, Christian

“…Deposition of the nuclear DNA/RNA-binding protein Fused in sarcoma (FUS) in cytosolic inclusions is a common hallmark of some cases of frontotemporal lobar…”
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Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD by Khosravi, Bahram, Hartmann, Hannelore, May, Stephanie, Möhl, Christoph, Ederle, Helena, Michaelsen, Meike, Schludi, Martin H, Dormann, Dorothee, Edbauer, Dieter

“…A repeat expansion in the non-coding region of C9orf72 gene is the most common mutation causing frontotemporal lobar degeneration (FTLD) and amyotrophic…”
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Central nervous system cholesterol metabolism in health and disease by Ho, Wan Y., Hartmann, Hannelore, Ling, Shuo‐Chien

“…Cholesterol is a ubiquitous and essential component of cellular membranes, as it regulates membrane structure and fluidity. Furthermore, cholesterol serves as…”
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Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon? by Hartmann, Hannelore, Ho, Wan Yun, Chang, Jer‐Cherng, Ling, Shuo‐Chien

“…Amyotrophic lateral sclerosis (ALS), the most common adult‐onset motor neuron disease, is characterized by the selective degeneration of motor neurons leading…”
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Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS/FTD by Khosravi, Bahram, LaClair, Kathrine D, Riemenschneider, Henrick, Zhou, Qihui, Frottin, Frédéric, Mareljic, Nikola, Czuppa, Mareike, Farny, Daniel, Hartmann, Hannelore, Michaelsen, Meike, Arzberger, Thomas, Hartl, F Ulrich, Hipp, Mark S, Edbauer, Dieter

“…The C9orf72 repeat expansion causes amyotrophic lateral sclerosis and frontotemporal dementia, but the poor correlation between C9orf72 ‐specific pathology and…”
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Hearing aids for young children: early detection assures the best outcome by Hartmann, Hannelore

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Englischunterricht bei Schwerhoerigen am Aufbaugymnasium (Teaching English to the Hard of Hearing in the University-Preparatory "Makeup" School) by Hartmann, Hannelore

“…Discusses the special problems of teaching foreign languages (specifically English) to the hard of hearing, including the monolingual approach and the…”
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