Search Results - "Hartman, Z"

The young HD 73583 (TOI-560) planetary system: two 10-M⊕ mini-Neptunes transiting a 500-Myr-old, bright, and active K dwarf by Armstrong, D J, Gandolfi, D, Carleo, I, Vidotto, A A, Villarreal D’Angelo, C, Oklopčić, A, Isaacson, H, Oddo, D, Sousa, S G, Persson, C M, Hellier, C, Howell, S, Howard, A, Redfield, S, Eisner, N, Georgieva, I Y, Dragomir, D, Bayliss, D, Nielsen, L D, Klein, B, Aigrain, S, Zhang, M, Teske, J, Twicken, J D, Jenkins, J, Esposito, M, Rodler, F, Adibekyan, V, Alarcon, J, Anderson, D R, Akana Murphy, J M, Barrado, D, Barros, S C C, Benneke, B, Bouchy, F, Bryant, E M, Butler, R P, Burt, J, Cabrera, J, Casewell, S, Chaturvedi, P, Cloutier, R, Cochran, W D, Crane, J, Crossfield, I, Crouzet, N, Dai, F, Deeg, H J, Deline, A, Demangeon, O D S, Dumusque, X, Figueira, P, Furlan, E, Gnilka, C, Goad, M R, Goffo, E, Gutiérrez-Canales, F, Hadjigeorghiou, A, Hartman, Z, Hatzes, A P, Harris, M, Henderson, B, Hirano, T, Hojjatpanah, S, Hoyer, S, Kabáth, P, Korth, J, Lillo-Box, J, Luque, R, Močnik, T, Muresan, A, Murgas, F, Nagel, E, Osborne, H L M, Osborn, A, Osborn, H P, Palle, E, Raimbault, M, Ricker, G R, Rubenzahl, R A, Stockdale, C, Santos, N C, Scott, N, Schwarz, R P, Shectman, S, Seager, S, Ségransan, D, Serrano, L M, Skarka, M, Smith, A M S, Šubjak, J, Tan, T G, Udry, S, Watson, C, Wheatley, P J, West, R, Winn, J N, Wang, S X, Wolfgang, A, Ziegler, C

“…ABSTRACT We present the discovery and characterization of two transiting planets observed by TESS in the light curves of the young and bright (V = 9.67) star…”
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Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes by Jo, Youngah, Hartman, Isamu Z, DeBose-Boyd, Russell A

“…Sterol-induced binding to Insigs in endoplasmic reticulum (ER) membranes triggers ubiquitination of the cholesterol biosynthetic enzyme…”
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TFAW survey II: six newly validated planets and 13 planet candidates from K2 by del Ser, D, Fors, O, del Alcázar, M, Dyachenko, V, Horch, E P, Tokovinin, A, Ziegler, C, van Belle, G T, Clark, C A, Hartman, Z D

“…ABSTRACT Searching for Earth-sized planets in data from Kepler’s extended mission (K2) is a niche that still remains to be fully exploited. The TFAW survey is…”
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HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling by Hartman, Z, Zhao, H, Agazie, Y M

“…One of the causes of breast cancer is overexpression of the human epidermal growth factor receptor 2 (HER2). Enhanced receptor autophosphorylation and…”
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Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver by Hwang, Seonghwan, Hartman, Isamu Z., Calhoun, Leona N., Garland, Kristina, Young, Gennipher A., Mitsche, Matthew A., McDonald, Jeffrey, Xu, Fang, Engelking, Luke, DeBose-Boyd, Russell A.

“…Accumulation of sterols in endoplasmic reticulum membranes stimulates the ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which…”
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The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment by Turpin, J, Ling, C, Crosby, E J, Hartman, Z C, Simond, A M, Chodosh, L A, Rennhack, J P, Andrechek, E R, Ozcelik, J, Hallett, M, Mills, G B, Cardiff, R D, Gray, J W, Griffith, O L, Muller, W J

“…Amplification and overexpression of erbB2/neu proto-oncogene is observed in 20–30% human breast cancer and is inversely correlated with the survival of the…”
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HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation by Poluektov, Yuri O, Kim, Aeryon, Hartman, Isamu Z, Sadegh-Nasseri, Scheherazade

“…Processing of antigens for presentation to helper T cells by MHC class II involves HLA-DM (DM) and HLA-DO (DO) accessory molecules. A mechanistic understanding…”
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Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients by Majai, G, Kiss, E, Tarr, T, Zahuczky, G, Hartman, Z, Szegedi, G, Fésüs, L

“…The clearance of apoptotic cells has an important role in the maintenance of tissue homeostasis and in the protection of tissues from the inflammatory and…”
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Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection by Sadegh-Nasseri, Scheherazade, Natarajan, Sateesh, Chou, Chih-Ling, Hartman, Isamu Z., Narayan, Kedar, Kim, AeRyon

“…T cells bearing αβ receptors recognize antigenic peptides bound to class I and class II glycoproteins encoded in the major histocompatibility complex (MHC)…”
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Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity by Osada, T, Yang, X Y, Hartman, Z C, Glass, O, Hodges, B L, Niedzwiecki, D, Morse, M A, Lyerly, H K, Amalfitano, A, Clay, T M

“…Recombinant serotype 5 adenovirus (Ad5) vectors lacking E1 expression induce robust immune responses against encoded transgenes in pre-clinical models, but…”
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Abstract P6-20-17: Targeting SHP2 for the treatment of HER2-positive breast cancer by Agazie, Y, Hartman, Z

“…Abstract Approximately 20% of breast cancer (BC) is caused by overexpression of the human epidermal growth factor receptor 2 (HER2). As a result, several…”
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Sequential Actions of the AAA-ATPase Valosin-containing Protein (VCP)/p97 and the Proteasome 19 S Regulatory Particle in Sterol-accelerated, Endoplasmic Reticulum (ER)-associated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase by Morris, Lindsey L., Hartman, Isamu Z., Jun, Dong-Jae, Seemann, Joachim, DeBose-Boyd, Russell A.

“…Accelerated endoplasmic reticulum (ER)-associated degradation (ERAD) of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase…”
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Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources by Kim, AeRyon, Hartman, Isamu Z., Poore, Brad, Boronina, Tatiana, Cole, Robert N., Song, Nianbin, Ciudad, M. Teresa, Caspi, Rachel R., Jaraquemada, Dolores, Sadegh-Nasseri, Scheherazade

“…Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we…”
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Theoretical and experimental studies of carbon nanotube electromechanical coupling by HARTMAN, A. Z, JOUZI, M, BARNETT, R. L, XU, J. M

“…We present an investigation into electromechanical coupling in carbon nanotubes by focusing on phonon frequency shifts as a result of charge injection. A…”
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Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets by Hartman, Isamu Z., Liu, Pingsheng, Zehmer, John K., Luby-Phelps, Katherine, Jo, Youngah, Anderson, Richard G.W., DeBose-Boyd, Russell A.

“…Sterol-induced binding to Insigs in the endoplasmic reticulum (ER) allows for ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the…”
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Studying MHC Class II Peptide Loading and Editing In Vitro by Kim, AeRyon, Ishizuka, Isabel Emiko, Hartman, Isamu Z, Poluektov, Yuri, Narayan, Kedar, Sadegh-Nasseri, Scheherazade

“…HLA-DM is now known to have a major contribution to the selection of immunodominant epitopes. A better understanding of the mechanisms controlling epitope…”
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A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes by Sadegh-Nasseri, Scheherazade, Hartman, Isamu Z, Kim, AeRyon, Cotter, Robert J, Walter, Kimberly, Dalai, Sarat K, Boronina, Tatiana, Griffith, Wendell, Lanar, David E, Schwenk, Robert, Krzych, Urszula, Cole, Robert N

“…A lack of current methods for major histocompatibility class II epitope identification prompted Isamu Hartman and his colleagues to develop a cell-free system…”
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HLA-DM targets the hydrogen bond between the histidine at position β81 and peptide to dissociate HLA-DR -peptide complexes by Kim, AeRyon, Khoruzhenko, Stanislav, Dalai, Sarat, Chou, Chih-Ling, Sadegh-Nasseri, Scheherazade, Hartman, Isamu Z, Narayan, Kedar

“…The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major histocompatibility (MHC) class II molecules during antigen processing; however, the…”
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TFAW survey II: 6 Newly Validated Planets and 13 Planet Candidates from K2 by del Ser, D, Fors, O, del Alcázar, M, Dyachenko, V, Horch, E. P, Tokovinin, A, Ziegler, C, van Belle, G. T, Clark, C. A, Hartman, Z. D

“…Searching for Earth-sized planets in data from Kepler's extended mission (K2) is a niche that still remains to be fully exploited. The TFAW survey is an…”
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The two rings of (50000) Quaoar by Pereira, C. L, Sicardy, B, Morgado, B. E, Braga-Ribas, F, Fernández-Valenzuela, E, Souami, D, Holler, B. J, Boufleur, R. C, Margoti, G, Assafin, M, Ortiz, J. L, Santos-Sanz, P, Epinat, B, Kervella, P, Desmars, J, Vieira-Martins, R, Kilic, Y, Gomes-Júnior, A. R, Camargo, J. I. B, Emilio, M, Vara-Lubiano, M, Kretlow, M, Albert, L, Alcock, C, Ball, J. G, Bender, K, Buie, M. W, Butterfield, K, Camarca, M, Castro-Chacón, J. H, Dunford, R, Fisher, R. S, Gamble, D, Geary, J. C, Gnilka, C. L, Green, K. D, Hartman, Z. D, Huang, C-K, Januszewski, H, Johnston, J, Kagitani, M, Kamin, R, Kavelaars, J. J, Keller, J. M, de Kleer, K. R, Lehner, M. J, Luken, A, Marchis, F, Marlin, T, McGregor, K, Nikitin, V, Nolthenius, R, Patrick, C, Redfield, S, Rengstorf, A. W, Reyes-Ruiz, M, Seccull, T, Skrutskie, M. F, Smith, A. B, Sproul, M, Stephens, A. W, Szentgyorgyi, A, Sánchez-Sanjuán, S, Tatsumi, E, Verbiscer, A, Wang, S-Y, Yoshida, F, Young, R, Zhang, Z-W

“…A&A 673, L4 (2023) Quaoar is a classical Trans-Neptunian Object (TNO) with an area equivalent diameter of 1,100 km and an orbital semi-major axis of 43.3…”
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