Search Results - "Hartman, Phil S"

Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain by Ishii, Takamasa, Takanashi, Yumi, Sugita, Koichi, Miyazawa, Masaki, Yanagihara, Rintaro, Yasuda, Kayo, Onouchi, Hiromi, Kawabe, Noboru, Nakata, Munehiro, Yamamoto, Yorihiro, Hartman, Phil S., Ishii, Naoaki

“…Summary The etiology of astrocyte dysfunction is not well understood even though neuronal defects have been extensively studied in a variety of neuronal…”
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Model animals for the study of oxidative stress from complex II by Ishii, Takamasa, Miyazawa, Masaki, Onouchi, Hiromi, Yasuda, Kayo, Hartman, Phil S., Ishii, Naoaki

“…Mitochondria play a role of energy production and produce intracellular reactive oxygen species (ROS), especially superoxide anion (O2−) as a byproduct of…”
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Single Plant Derived Nanotechnology for Synergistic Antibacterial Therapies by Kalluri, Jhansi R, Gonzalez-Rodriguez, Roberto, Hartman, Phil S, Loni, Armando, Canham, Leigh T, Coffer, Jeffery L

“…Multiple new approaches to tackle multidrug resistant infections are urgently needed and under evaluation. One nanotechnology-based approach to delivering new…”
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Genetically induced oxidative stress in mice causes thrombocytosis, splenomegaly and placental angiodysplasia that leads to recurrent abortion by Ishii, Takamasa, Miyazawa, Masaki, Takanashi, Yumi, Tanigawa, Maya, Yasuda, Kayo, Onouchi, Hiromi, Kawabe, Noboru, Mitsushita, Junji, Hartman, Phil S, Ishii, Naoaki

“…Historical data in the 1950s suggests that 7%, 11%, 33%, and 87% of couples were infertile by ages 30, 35, 40 and 45, respectively. Up to 22.3% of infertile…”
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Efficient marker-free recovery of custom genetic modifications with CRISPR/Cas9 in Caenorhabditis elegans by Arribere, Joshua A, Bell, Ryan T, Fu, Becky X H, Artiles, Karen L, Hartman, Phil S, Fire, Andrew Z

“…Facilitated by recent advances using CRISPR/Cas9, genome editing technologies now permit custom genetic modifications in a wide variety of organisms. Ideally,…”
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Mitochondrial superoxide anion (O₂·-) inducible "mev-1" animal models for aging research by Ishii, Takamasa, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Miyazawa, Masaki, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Hartman, Phil S., Texas Christian University, Fort Worth, TX, USA, Ishii, Naoaki, Tokai University School of Medicine, Isehara, Kanagawa, Japan

“…Most intracellular reactive oxygen species (ROS), especially superoxide anion (O₂·-) that is converted from oxygen, are overproduced by excessive electron…”
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Chromosome dosage as a life span determinant in Caenorhabiditis elegans by Hartman, Phil S., Ishii, Naoaki

“…Caenorhabiditis elegans males live longer than hermaphrodites when cultured individually. Since hermaphrodites contain a pair of X chromosomes (XX) and males…”
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Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans by Hartman, Phil S., Ishii, Naoaki, Kayser, Ernst-Bernhard, Morgan, Phil G., Sedensky, Margaret M.

“…In the nematode Caenorhabditis elegans, mutations have been previously isolated that affect the activities of Complex I ( gas-1) and Complex II ( mev-1), two…”
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Mitochondrial superoxide anion (O 2 · - ) inducible "mev-1" animal models for aging research by Ishii, Takamasa, Miyazawa, Masaki, Hartman, Phil S, Ishii, Naoaki

“…Most intracellular reactive oxygen species (ROS), especially superoxide anion ($O_2^{{\bullet}_-}$) that is converted from oxygen, are overproduced by…”
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Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models by Ishii, Takamasa, Yasuda, Kayo, Miyazawa, Masaki, Mitsushita, Junji, Johnson, Thomas E., Hartman, Phil S., Ishii, Naoaki

“…•SDHC mutation causes complex II deficiency-dependent oxidative stress in female reproductive organs, not male.•The oxidative stress causes ovarian hemangiomas…”
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Repeated temperature fluctuation extends the life span of Caenorhabditis elegans in a daf-16-dependent fashion by Galbadage, Thushara, Hartman, Phil S.

“…Thermocyclers were utilized to regularly shift nematodes between 12 °C and 25 °C throughout their life spans. When wild-type worms (N2) were “thermocycled”…”
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Mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerates age-dependent corneal cell dysfunctions by Onouchi, Hiromi, Ishii, Takamasa, Miyazawa, Masaki, Uchino, Yuichi, Yasuda, Kayo, Hartman, Phil S, Kawai, Kenji, Tsubota, Kazuo, Ishii, Naoaki

“…The Tet-mev-1 mouse expressing a mitochondrial complex-II mutated SDHC(V69E) gene controlled by a tetracycline (Tet)-On/Off system can overproduce O(2)(·-) and…”
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Sustained Antibacterial Activity from Triclosan-Loaded Nanostructured Mesoporous Silicon by Wang, Mengjia, Coffer, Jeffery L, Dorraj, Katrina, Hartman, Phil S, Loni, Armando, Canham, Leigh T

“…In this work, nanostructured particles of porous silicon are demonstrated to act as an effective carrier for the sustained delivery of antibacterial agents…”
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A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans by Fujii, Michihiko, Yasuda, Kayo, Hartman, Phil S., Ayusawa, Dai, Ishii, Naoaki

“…rad‐8 is an interesting mutant that shows increased sensitivities to UV radiation and reactive oxygen species in the nematode Caenorhabditis elegans. In this…”
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A comparison of mutations induced by accelerated iron particles versus those induced by low earth orbit space radiation in the FEM-3 gene of Caenorhabditis elegans by Hartman, P S, Hlavacek, A, Wilde, H, Lewicki, D, Schubert, W, Kern, R G, Kazarians, G A, Benton, E V, Benton, E R, Nelson, G A

“…The fem-3 gene of Caenorhabditis elegans was employed to determine the mutation frequency as well as the nature of mutations induced by low earth orbit space…”
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Ethyl methanesulfonate induces mutations in Caenorhabditis elegans embryos at a high frequency by Hartman, Phil S, Barry, James, Finstad, Whitney, Khan, Numan, Tanaka, Masayuki, Yasuda, Kayo, Ishii, Naoaki

“…Mutagenesis protocols typically call for exposure of late-stage larvae or adults to a mutagen with the intention of inducing mutations in a robust germ line…”
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A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans: Identification of rad-8 in C. elegans by Fujii, Michihiko, Yasuda, Kayo, Hartman, Phil S., Ayusawa, Dai, Ishii, Naoaki

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Replication in UV-irradiated Caenorhabditis elegans embryos by Jones, C A, Hartman, P S

“…Replication continues in wild-type (but not rad mutant) Caenorhabditis elegans embryos even after exposure to massive fluences of UV radiation. It is of…”
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Genetic and molecular analyses of UV radiation-induced mutations in the fem-3 gene of Caenorhabditis elegans by Hartman, P S, De Wilde, D, Dwarakanath, V N

“…The utility of a new target gene (fem-3) is described for investigating the molecular nature of mutagenesis in the nematode Caenorhabditis elegans. As a…”
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Inactivation of wild-type and rad mutant Caenorhabditis elegans by 8-methoxypsoralen and near ultraviolet radiation by Hartman, P S, Marshall, A

“…Survival of wild-type and four radiation-sensitive (rad) mutants of the nematode Caenorhabditis elegans was determined after near-UV irradiation in the…”
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