Search Results - "Hartman, Isamu Z."

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes by Jo, Youngah, Hartman, Isamu Z, DeBose-Boyd, Russell A

“…Sterol-induced binding to Insigs in endoplasmic reticulum (ER) membranes triggers ubiquitination of the cholesterol biosynthetic enzyme…”
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Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver by Hwang, Seonghwan, Hartman, Isamu Z., Calhoun, Leona N., Garland, Kristina, Young, Gennipher A., Mitsche, Matthew A., McDonald, Jeffrey, Xu, Fang, Engelking, Luke, DeBose-Boyd, Russell A.

“…Accumulation of sterols in endoplasmic reticulum membranes stimulates the ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which…”
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HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation by Poluektov, Yuri O, Kim, Aeryon, Hartman, Isamu Z, Sadegh-Nasseri, Scheherazade

“…Processing of antigens for presentation to helper T cells by MHC class II involves HLA-DM (DM) and HLA-DO (DO) accessory molecules. A mechanistic understanding…”
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Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection by Sadegh-Nasseri, Scheherazade, Natarajan, Sateesh, Chou, Chih-Ling, Hartman, Isamu Z., Narayan, Kedar, Kim, AeRyon

“…T cells bearing αβ receptors recognize antigenic peptides bound to class I and class II glycoproteins encoded in the major histocompatibility complex (MHC)…”
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Sequential Actions of the AAA-ATPase Valosin-containing Protein (VCP)/p97 and the Proteasome 19 S Regulatory Particle in Sterol-accelerated, Endoplasmic Reticulum (ER)-associated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase by Morris, Lindsey L., Hartman, Isamu Z., Jun, Dong-Jae, Seemann, Joachim, DeBose-Boyd, Russell A.

“…Accelerated endoplasmic reticulum (ER)-associated degradation (ERAD) of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase…”
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Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources by Kim, AeRyon, Hartman, Isamu Z., Poore, Brad, Boronina, Tatiana, Cole, Robert N., Song, Nianbin, Ciudad, M. Teresa, Caspi, Rachel R., Jaraquemada, Dolores, Sadegh-Nasseri, Scheherazade

“…Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we…”
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Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets by Hartman, Isamu Z., Liu, Pingsheng, Zehmer, John K., Luby-Phelps, Katherine, Jo, Youngah, Anderson, Richard G.W., DeBose-Boyd, Russell A.

“…Sterol-induced binding to Insigs in the endoplasmic reticulum (ER) allows for ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the…”
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Studying MHC Class II Peptide Loading and Editing In Vitro by Kim, AeRyon, Ishizuka, Isabel Emiko, Hartman, Isamu Z, Poluektov, Yuri, Narayan, Kedar, Sadegh-Nasseri, Scheherazade

“…HLA-DM is now known to have a major contribution to the selection of immunodominant epitopes. A better understanding of the mechanisms controlling epitope…”
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A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes by Sadegh-Nasseri, Scheherazade, Hartman, Isamu Z, Kim, AeRyon, Cotter, Robert J, Walter, Kimberly, Dalai, Sarat K, Boronina, Tatiana, Griffith, Wendell, Lanar, David E, Schwenk, Robert, Krzych, Urszula, Cole, Robert N

“…A lack of current methods for major histocompatibility class II epitope identification prompted Isamu Hartman and his colleagues to develop a cell-free system…”
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HLA-DM targets the hydrogen bond between the histidine at position β81 and peptide to dissociate HLA-DR -peptide complexes by Kim, AeRyon, Khoruzhenko, Stanislav, Dalai, Sarat, Chou, Chih-Ling, Sadegh-Nasseri, Scheherazade, Hartman, Isamu Z, Narayan, Kedar

“…The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major histocompatibility (MHC) class II molecules during antigen processing; however, the…”
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A novel Minimalist Cell-Free MHC Class II Antigen Processing System Identifies Immunodominant Epitopes by Hartman, Isamu Z., Kim, AeRyon, Cotter, Robert J., Walter, Kimberly, Dalai, Sarat K., Boronina, Tatiana, Griffith, Wendell, Schwenk, Robert, Lanar, David E., Krzych, Urszula, Cole, Robert N., Sadegh-Nasseri, Scheherazade

“…Immunodominance is defined as restricted responsiveness of T cells to a few selected epitopes from complex antigens. Strategies currently used for elucidating…”
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HLA-DO as the Optimizer of Epitope Selection for MHC Class II Antigen Presentation. e71228 by Poluektov, Yuri O, Kim, AeRyon, Hartman, Isamu Z, Sadegh-Nasseri, Scheherazade

“…Processing of antigens for presentation to helper T cells by MHC class II involves HLA-DM (DM) and HLA-DO (DO) accessory molecules. A mechanistic understanding…”
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How HLA-DM works: recognition of MHC II conformational heterogeneity by Sadegh-Nasseri, Scheherazade, Chou, Chih-Ling, Hartman, Isamu Z, Kim, AeRyon, Narayan, Kedar

“…Helper T cells respond to peptide antigens derived from exogenous sources presented by MHC II on antigen presenting cells. Antigens from pathogens are…”
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HLA-DM targets the hydrogen bond between the histidine at position b81 and peptide to dissociate HLA-DR-peptide complexes by Narayan, Kedar, Chou, Chih-Ling, Kim, AeRyon, Hartman, Isamu Z, Dalai, Sarat, Khoruzhenko, Stanislav, Sadegh-Nasseri, Scheherazade

“…The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major histocompatibility (MHC) class II molecules during antigen processing; however, the…”
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HLA-DM targets the hydrogen bond between the histidine at position [beta]81 and peptide to dissociate HLA-DR-peptide complexes by Narayan, Kedar, Chih-Ling Chou, Kim, AeRyon, Hartman, Isamu Z, Dalai, Sarat, Khoruzhenko, Stanislav, Sadegh-Nasseri, Scheherazade

“…The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major histocompatibility (MHC) class II molecules during antigen processing; however, the…”
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HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes by Narayan, Kedar, Chou, Chih-Ling, Kim, AeRyon, Hartman, Isamu Z, Dalai, Sarat, Khoruzhenko, Stanislav, Sadegh-Nasseri, Scheherazade

“…The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major histocompatibility (MHC) class II molecules during antigen processing; however, the…”
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Regulation of the RAG-1 promoter by the NF-Y transcription factor by Brown, ST, Miranda, GA, Galic, Z, Hartman, IZ, Lyon, CJ, Aguilera, RJ

“…We have cloned the RAG-1 promoter region and have determined that almost all detectable promoter activity resides within a 208-bp fragment. Sequence analysis…”
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