Search Results - "Hartline, Caroll B."

CMX001 Potentiates the Efficacy of Acyclovir in Herpes Simplex Virus Infections by Prichard, Mark N, Kern, Earl R, Hartline, Caroll B, Lanier, E. Randall, Quenelle, Debra C

“…Although acyclovir (ACV) has proven to be of value in the therapy of certain herpes simplex virus (HSV) infections, there is a need for more effective…”
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Synthesis and Antiviral Activities of Methylenecyclopropane Analogs with 6-Alkoxy and 6-Alkylthio Substitutions That Exhibit Broad-Spectrum Antiviral Activity against Human Herpesviruses by Prichard, Mark N, Williams, John D, Komazin-Meredith, Gloria, Khan, Atiyya R, Price, Nathan B, Jefferson, Geraldine M, Harden, Emma A, Hartline, Caroll B, Peet, Norton P, Bowlin, Terry L

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Selection and Recombinant Phenotyping of a Novel CMX001 and Cidofovir Resistance Mutation in Human Cytomegalovirus by JAMES, Scott H, PRICE, Nathan B, HARTLINE, Caroll B, RANDALL LANIER, E, PRICHARD, Mark N

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Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions by KOMAZIN-MEREDITH, Gloria, SUNWEN CHOU, PRICHARD, Mark N, HARTLINE, Caroll B, CARDINALE, Steven C, COMEAU, Katelyn, WILLIAMS, John D, KHAN, Atiyya R, PEET, Norton P, BOWLIN, Terry L

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Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes by PRICHARD, Mark N, SZTUL, Elizabeth, KERN, Earl R, DAILY, Shannon L, PERRY, Amie L, FREDERICK, Samuel L, GILL, Rachel B, HARTLINE, Caroll B, STREBLOW, Daniel N, VARNUM, Susan M, SMITH, Richard D

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Ether Lipid-Ester Prodrugs of Acyclic Nucleoside Phosphonates: Activity against Adenovirus Replication In Vitro by Hartline, Caroll B., Gustin, Kortney M., Wan, William B., Ciesla, Stephanie L., Beadle, James R., Hostetler, Karl Y., Kern, Earl R

“…The acyclic nucleoside phosphonate cidofovir (CDV) and its closely related analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine ([S]-HPMPA) have been…”
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Human Cytomegalovirus UL97 Kinase Is Required for the Normal Intranuclear Distribution of pp65 and Virion Morphogenesis by PRICHARD, Mark N, BRITT, William J, DAILY, Shannon L, HARTLINE, Caroll B, KERN, Earl R

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Cyclopropavir Inhibits the Normal Function of the Human Cytomegalovirus UL97 Kinase by James, Scott H, Hartline, Caroll B, Harden, Emma A, Driebe, Elizabeth M, Schupp, James M, Engelthaler, David M, Keim, Paul S, Bowlin, Terry L, Kern, Earl R, Prichard, Mark N

“…Cyclopropavir (CPV) is active against human cytomegalovirus (CMV), as well as both variants of human herpesvirus 6 and human herpesvirus 8. The mechanism of…”
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Comparative Activities of Lipid Esters of Cidofovir and Cyclic Cidofovir against Replication of Herpesviruses In Vitro by WILLIAMS-AZIZ, Stephanie L, HARTLINE, Caroll B, HARDEN, Emma A, DAILY, Shannon L, PRICHARD, Mark N, KUSHNER, Nicole L, BEADLE, James R, WAN, W. Brad, HOSTETLER, Karl Y, KERN, Earl R

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Inhibition of Herpesvirus Replication by 5-Substituted 4′-Thiopyrimidine Nucleosides by PRICHARD, Mark N, QUENELLE, Debra C, SECRIST, John A, KERN, Earl R, HARTLINE, Caroll B, HARDEN, Emma A, JEFFERSON, Geraldine, FREDERICK, Samuel L, DAILY, Shannon L, WHITLEY, Richard J, TIWARI, Kamal N, MADDRY, Joseph A

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Oral Activity of a Methylenecyclopropane Analog, Cyclopropavir, in Animal Models for Cytomegalovirus Infections by Kern, Earl R, Bidanset, Deborah J, Hartline, Caroll B, Yan, Zhaohua, Zemlicka, Jiri, Quenelle, Debra C

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In Vitro Activities of Benzimidazole d- and l-Ribonucleosides against Herpesviruses by WILLIAMS, Stephanie L, HARTLINE, Caroll B, KUSHNER, Nicole L, HARDEN, Emma A, BIDANSET, Deborah J, DRACH, John C, TOWNSEND, Leroy B, UNDERWOOD, Mark R, BIRON, Karen K, KERN, Earl R

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In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication by KERN, Earl R, KUSHNER, Nicole L, HARTLINE, Caroll B, WILLIAMS-AZIZ, Stephanie L, HARDEN, Emma A, SHAOMAN ZHOU, ZEMLICKA, Jiri, PRICHARD, Mark N

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Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides by Williams, John D., Khan, Atiyya R., Harden, Emma A., Hartline, Caroll B., Jefferson, Geraldine M., Keith, Kathy A., Prichard, Mark N., Zemlicka, Jiri, Peet, Norton P., Bowlin, Terry L.

“…A second-generation series of substituted methylenecyclopropane nucleosides (MCPNs) has been synthesized and evaluated for antiviral activity against a panel…”
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Inhibition of Herpesvirus Replication by Hexadecyloxypropyl Esters of Purine- and Pyrimidine-Based Phosphonomethoxyethyl Nucleoside Phosphonates by PRICHARD, Mark N, HARTLINE, Caroll B, HARDEN, Emma A, DAILY, Shannon L, BEADLE, James R, VALIAEVA, Nadejda, KERN, Earl R, HOSTETLER, Karl Y

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In Silico Design and Experimental Validation of Novel Oxazole Derivatives Against Varicella zoster virus by Kovalishyn, Vasyl, Severin, Oleksandr, Kachaeva, Maryna, Kobzar, Oleksandr, Keith, Kathy A., Harden, Emma A., Hartline, Caroll B., James, Scott H., Vovk, Andriy, Brovarets, Volodymyr

“…Varicella zoster virus (VZV) infection causes severe disease such as chickenpox, shingles, and postherpetic neuralgia, often leading to disability…”
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A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox-, adeno-, and herpesviruses by Hartline, Caroll B., Keith, Kathy A., Eagar, Jessica, Harden, Emma A., Bowlin, Terry L., Prichard, Mark N.

“…The search for new compounds with a broad spectrum of antiviral activity is important and requires the evaluation of many compounds against several distinct…”
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A standardized approach to the evaluation of antivirals against DNA viruses: Polyomaviruses and lymphotropic herpesviruses by Keith, Kathy A., Hartline, Caroll B., Bowlin, Terry L., Prichard, Mark N.

“…The search for new compounds with a broad spectrum of antiviral activity is important and requires the evaluation of many compounds against several distinct…”
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Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir by Gill, Rachel B, Frederick, Samuel L, Hartline, Caroll B, Chou, Sunwen, Prichard, Mark N

“…The UL97 kinase has been shown to phosphorylate and inactivate the retinoblastoma protein (Rb) and has three consensus Rb-binding motifs that might contribute…”
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Xenotransplantation panel for the detection of infectious agents in pigs by Hartline, Caroll B., Conner, Ra'Shun L., James, Scott H., Potter, Jennifer, Gray, Edward, Estrada, Jose, Tector, Mathew, Tector, A. Joseph, Prichard, Mark N.

“…Background Recent advances in xenotransplantation have produced organs from pigs that are well tolerated in primate models because of genetic changes…”
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