Search Results - "Hartley, Cynthia"

Radioprotection of Mice by Recombinant Rat Stem Cell Factor by Zsebo, Krisztina M., Smith, Kent A., Hartley, Cynthia A., Greenblatt, Melvin, Cooke, Keegan, Rich, William, McNiece, Ian K.

“…Treatment with recombinant rat stem cell factor (rSCF) protects mice from the lethal effects of irradiation. Mice treated with a single dose of rSCF prior to…”
Get full text

Comparison of epoetin alfa and darbepoetin alfa biological activity under different administration schedules in normal mice by Sasu, Barbra J, Hartley, Cynthia, Schultz, Henry, McElroy, Patricia, Khaja, Raheemuddin, Elliott, Steven, Egrie, Joan C, Browne, Jeffrey K, Begley, C Glenn, Molineux, Graham

“…The unit of erythropoietic activity has long been the standard by which erythropoietic agents are judged, but the development of long-acting agents such as…”
Get more information

Most purported antibodies to the human granulocyte colony-stimulating factor receptor are not specific by deBruin, Cortney, Lincoln, Patrice, Hartley, Cynthia, Shehabeldin, Amro, Van, Gwyneth, Szilvassy, Stephen J

“…Objective Antibodies to human granulocyte colony-stimulating factor receptor (HuG-CSFR) are widely available and have been used in numerous studies to evaluate…”
Get full text

Fetal Hemoglobin Expression Is Differentially Affected by Inhibition of the Proposed Dred Complex Constituents, LSD1 and DNMT1 by Arvedson, Tara L, Tran, Lynn, Ross, Sandra L, Yoder, Sean, Hertz, Alexandra, Hale, Kari, Eschelbach, John, Dineen, Tom, Matyas, Stephanie, Hartley, Cynthia, Morgenstern, Kurt, Winters, Dwight, Cindy, Park, Molineux, Graham, Coxon, Angela

“…Abstract 3263 Sickle cell disease and beta thalassemia are disorders caused by mutations in adult hemoglobin (HbA) or defects in HbA expression. A potential…”
Get full text

A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans by Molineux, Graham, Kinstler, Olaf, Briddell, Bob, Hartley, Cynthia, McElroy, Patricia, Kerzic, Patrick, Sutherland, Weston, Stoney, Greg, Kern, Brent, Fletcher, Frederick A., Cohen, Art, Korach, Elliot, Ulich, Tom, McNiece, Ian, Lockbaum, Pamela, Miller-Messana, Mary Ann, Gardner, Sheila, Hunt, Thomas, Schwab, Gisela

“…Granulocyte colony-stimulating factor (G-CSF) has proven effective in the prophylaxis of chemotherapy-induced neutropenia and as a mobilizer of peripheral…”
Get full text

Darbepoietin alfa potentiates the efficacy of radiation therapy in mice with corrected or uncorrected anemia by SHOUCHENG NING, HARTLEY, Cynthia, MOLINEUX, Graham, KNOX, Susan J

“…Darbepoietin alfa (DA) is a long-acting analogue of erythropoietin that has reduced receptor affinity and enhanced biological activity. Experiments were done…”
Get full text

New Longer Acting Erythropoiesis Stimulating Proteins (ESPs) Correct Anemia with a Less Frequent Dosing Schedule in a Mouse Model by Hartley, Cynthia A., McElroy, Patricia, Khaja, Raheem, Molineux, Graham

“…Introduction: Recombinant human erythropoietin (rHuEPO) has become a standard treatment for the alleviation of anemia resulting from chronic renal failure and…”
Get full text

Darbepoetin alfa Radiosensitizes Tumors Independent of Anemia or the Correction of Anemia by Ning, Shoucheng, Angus, Sinclair, Cynthia, Hartley, Susan, Knox

“…Darbepoetin alfa (DA) is a FDA approved long acting erythropoietic protein. We hypothesized that correction of anemia in tumor-bearing mice by DA would…”
Get full text

Chronic Exposure to Retroviral Vector Encoded MGDF (mpl-Ligand) Induces Lineage-Specific Growth and Differentiation of Megakaryocytes in Mice by Yan, Xiao-Qiang, Lacey, David, Fletcher, Frederick, Hartley, Cynthia, McElroy, Patricia, Sun, Yu, Xia, Min, Mu, Sharon, Saris, Chris, Hill, David, Hawley, Robert G., McNiece, Ian K.

“…Megakaryocyte growth and development factor (MGDF) has recently been identified as a ligand for the c-mpl receptor. Using retroviral-mediated gene transfer,…”
Get full text

Kinetics of haematopoietic recovery after dose‐intensive chemo/radiotherapy in mice: optimized erythroid support with darbepoetin alpha by Hartley, Cynthia, Elliott, Steve, Begley, C. Glenn, McElroy, Patricia, Sutherland, Weston, Khaja, Raheem, Heatherington, Anne C., Graves, Tom, Schultz, Henry, Del Castillo, Juan, Molineux, Graham

“…Despite its frequency and impact on clinical outcomes, anaemia in cancer patients remains poorly understood and suboptimally treated. The definition of optimum…”
Get full text

Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients by Molineux, G, Hartley, C, McElroy, P, McCrea, C, McNiece, IK

“…We have investigated the potential of PEGylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF), a molecule related to…”
Get full text

Treatment with sd/01 relative to chemotherapy in mice by Hartley, Cynthia, McElroy, Trish, Sutherland, Wes, Molineux, Graham

Get full text

Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation by MOLINEUX, G, HARTLEY, C. A, MCELROY, P, MCREA, C, MCNIECE, I. K

“…Megakaryocyte growth and development factor (MGDF) is a recently characterized ligand for the cell surface receptor mpl. We have evaluated the effects of…”
Get full text

Neutropenia in a novel anti-mg-csf autoantibody mouse model by Coccia, Marco, Hartley, Cynthia, Sutherland, Wes, McElroy, Patricia, Del Castillo, Juan, Pistillo, Jeanne, Molineux, Graham

Get full text

PEG-rHuMGDF promotes multilineage hematopoietic recovery in myelosuppressed mice by Ulich, Thomas R, del Castillo, Juan, Senaldi, Giorgio, Hartley, Cynthia, Molineux, Graham

“…PEG-rHuMGDF administered to normal mice is a lineage-specific growth factor for megakaryocytes and platelets as judged by morphologic examination of…”
Get full text

Chronic expression of murine flt3 ligand in mice results in increased circulating white blood cell levels and abnormal cellular infiltrates associated with splenic fibrosis by JUAN, T. S.-C, MCNIECE, I. K, FLETCHER, F. A, VAN, G, LACEY, D, HARTLEY, C, MCELROY, P, SUR, Y, ARGENTO, J, HILL, D, YAN, X.-Q

“…The effect of chronic expression of flt3 ligand (FL) on in vivo hematopoiesis was studied. Retroviral vector-mediated gene transfer was used in a mouse model…”
Get full text

Prolonged neutropenia in a novel mouse granulocyte colony-stimulating factor neutralizing auto-immunoglobulin G mouse model by Coccia, Marco A., Hartley, Cynthia, Sutherland, Weston, Del Castillo, Juan, McElroy, Patricia, Pistillo, Jeanne, Tarpley, John E., Molineux, Graham

“…Therapeutic use of recombinant human cytokines in humans can result in the generation of drug-specific antibodies. To predetermine the maximum potential…”
Get full text

An Analysis of the Effects of Combined Treatment with rmGM‐CSF and PEG‐rHuMGDF in Murine Bone Marrow Transplant Recipients by Molineux, Graham, Hartley, Cynthia, McElroy, Patricia, McCrea, Clay, Kerzic, Patrick, McNiece, Ian

“…We have studied the potential of combination growth factor treatment with GM‐CSF and megakaryocyte growth and development factor (MGDF) to stimulate…”
Get full text

Chronic Expression of Murine flt3 Ligand in Mice Results in Increased Circulating White Blood Cell Levels and Abnormal Cellular Infiltrates Associated With Splenic Fibrosis by Juan, Todd S.-C., McNiece, Ian K., Van, Gwenneth, Lacey, David, Hartley, Cynthia, McElroy, Patricia, Sun, Yu, Argento, Julie, Hill, David, Yan, Xiao-Qiang, Fletcher, Frederick A.

“…The effect of chronic expression of flt3 ligand (FL) on in vivo hematopoiesis was studied. Retroviral vector-mediated gene transfer was used in a mouse model…”
Get full text

The role of stem cell factor in mobilization of peripheral blood progenitor cells: synergy with G-CSF by McNiece, I K, Briddell, R A, Hartley, C A, Andrews, R G

“…The use of cytokine mobilized peripheral blood progenitor cells (PBPC) in transplantation following chemotherapy has led to enhanced engraftment…”
Get more information