Search Results - "Hartl, Tom A"

Stable Chromosome Condensation Revealed by Chromosome Conformation Capture by Eagen, Kyle P., Hartl, Tom A., Kornberg, Roger D.

“…Chemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal interaction, referred to as topologically associating domains (TADs),…”
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Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes by Bauer, Christopher R, Hartl, Tom A, Bosco, Giovanni

“…The eukaryotic nucleus is both spatially and functionally partitioned. This organization contributes to the maintenance, expression, and transmission of…”
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Chromosome Alignment and Transvection Are Antagonized by Condensin II by Hartl, Tom A, Smith, Helen F, Bosco, Giovanni

“…Polytene chromosome structure is a characteristic of some polyploid cells where several to thousands of chromatids are closely associated with perfect…”
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Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma by Purzner, Teresa, Purzner, James, Buckstaff, Taylor, Cozza, Giorgio, Gholamin, Sharareh, Rusert, Jessica M, Hartl, Tom A, Sanders, John, Conley, Nicholas, Ge, Xuecai, Langan, Marc, Ramaswamy, Vijay, Ellis, Lauren, Litzenburger, Ulrike, Bolin, Sara, Theruvath, Johanna, Nitta, Ryan, Qi, Lin, Li, Xiao-Nan, Li, Gordon, Taylor, Michael D, Wechsler-Reya, Robert J, Pinna, Lorenzo A, Cho, Yoon-Jae, Fuller, Margaret T, Elias, Joshua E, Scott, Matthew P

“…A major limitation of targeted cancer therapy is the rapid emergence of drug resistance, which often arises through mutations at or downstream of the drug…”
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Galactokinase 1 is the source of elevated galactose‐1‐phosphate and cerebrosides are modestly reduced in a mouse model of classic galactosemia by Mangini, Linley, Lawrence, Roger, Lopez, Manuel E., Graham, Timothy C., Bauer, Christopher R., Nguyen, Hang, Su, Cheng, Ramphal, John, Crawford, Brett E., Hartl, Tom A.

“…Classic galactosemia (CG) arises from loss‐of‐function mutations in the Galt gene, which codes for the enzyme galactose‐1‐phosphate uridylyltransferase (GALT),…”
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Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis by Hartl, Tom A, Sweeney, Sarah J, Knepler, Peter J, Bosco, Giovanni

“…Several meiotic processes ensure faithful chromosome segregation to create haploid gametes. Errors to any one of these processes can lead to zygotic aneuploidy…”
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Wing tips: The wing disc as a platform for studying Hedgehog signaling by Hartl, Tom A., Scott, Matthew P.

“…•We describe imaginal wing disc development and anatomies of the wing disc and wing.•We discuss how Hh signaling controls patterning of the wing.•We outline…”
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Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is regulated by the condensin cap-h2 and its partner Mrg15 by Smith, Helen F, Roberts, Meredith A, Nguyen, Huy Q, Peterson, Maureen, Hartl, Tom A, Wang, Xiao-Jun, Klebba, Joseph E, Rogers, Gregory C, Bosco, Giovanni

“…Dynamic regulation of chromosome structure and organization is critical for fundamental cellular processes such as gene expression and chromosome segregation…”
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Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila by Hartl, Tom A, Ni, Julie, Cao, Jian, Suyama, Kaye L, Patchett, Stephanie, Bussiere, Cyril, Gui, Dan Yi, Tang, Sheng, Kaplan, Daniel D, Fish, Matthew, Johnson, Arlen W, Scott, Matthew P

“…Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and…”
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Condensin II Resolves Chromosomal Associations to Enable Anaphase I Segregation in Drosophila Male Meiosis: e1000228 by Hartl, Tom A, Sweeney, Sarah J, Knepler, Peter J, Bosco, Giovanni

“…Several meiotic processes ensure faithful chromosome segregation to create haploid gametes. Errors to any one of these processes can lead to zygotic aneuploidy…”
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